Significance of immune response to Mycobacterium tuberculosis culture filtrate protein antigens in cerebrospinal fluid of tuberculous meningitis patients: A search for diagnostic marker.

Significance of immune response to Mycobacterium tuberculosis culture filtrate protein antigens in cerebrospinal fluid of tuberculous meningitis patients: A search for diagnostic marker. J Immunoassay Immunochem. 2016 Jul 25; Authors: Giribhattanavar P, Kumar K, Raajasekar S, Chandrashekar N, Patil S Abstract Mycobacterium tuberculosis (H37Ra) culture filtrate proteins (CFP) are explored as a diagnostic marker for tuberculous meningitis (TBM). Cerebrospinal fluid (CSF) samples from patients were categorized as confirmed (n=47), suspected (n=20) and non-TBM (n=25) cases. Immune response by western-blot revealed TBM CSF samples are having heterogeneous response to CFP. CFP ELISA was 92% sensitive and 38.30% specific. ODs of confirmed TBM and non-TBM cases were significantly different (P<0.0001) and also the suspected TBM and non-TBM cases (P=0.0001). No significant difference noticed in TBM and suspected TBM (P=0.90). Thus, CFP can be a better biomarker for the diagnosis of TBM. PMID: 27454259 [PubMed - as supplied by publisher]
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research