Filtered By:
Vaccination: Covid Vaccine
This page shows you your search results in order of date. This is page number 19.
Order by Relevance | Date
Total 26665 results found since Jan 2013.
Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy
Cell Mol Immunol. 2023 Sep 5. doi: 10.1038/s41423-023-01080-3. Online ahead of print.ABSTRACTSolid organ transplant (SOT) recipients receive immunosuppressive drugs (ISDs) and are susceptible to developing severe COVID-19. Here, we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients (n = 136) treated with different ISDs. We demonstrate that a combination of a calcineurin inhibitor (CNI), mycophenolate mofetil (MMF), and prednisone (Pred) treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular response. Such defects have clinical consequences bec...
Source: Cellular and Molecular Immunology - September 4, 2023 Category: Molecular Biology Authors: Qi Chen Adeline Chia Shou Kit Hang Amy Lim Wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti Source Type: research
Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children
Clin Immunol. 2023 Sep 1:109751. doi: 10.1016/j.clim.2023.109751. Online ahead of print.ABSTRACTDespite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well as the severe cardiac involvement reported in Multisystem inflammatory syndrome in children (MIS-C) appear more frequent in young adult males. Herein, we firstly report on the inflammatory profiles of patients experiencing c-AEFI in comparison with age, pubertal age and gender matched MIS-C with cardiac involvement. Proteins related to systemic inflammation were found higher in MI...
Source: Clinical Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Donato Amodio Giuseppe Rubens Pascucci Nicola Cotugno Chiara Rossetti Emma Concetta Manno Chiara Pighi Elena Morrocchi Annamaria D'Alessandro Marco Alfonso Perrone Alessandra Valentini Alessio Franceschini Marcello Chinali Annalisa Deodati Chiara Azzari P Source Type: research
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
This article represents a comprehensive review of the function, structure and inhibition of SARS-CoV and -CoV-2 Mpro, including structure-activity relationships, protein-inhibitor interactions and clinical trial status.PMID:37659195 | DOI:10.1016/j.ejmech.2023.115772
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Xin Li Yongcheng Song Source Type: research
The impact of the COVID-19 pandemic on parental vaccine hesitancy: A cross-sectional survey
CONCLUSION: Our study demonstrates that parental perceptions about childhood vaccines have been affected by the COVID-19 pandemic through geographic and social clustering of non-vaccination. Beliefs about the COVID-19 vaccine have spillover with beliefs about childhood vaccines, and more negative beliefs may be clustering in areas with low vaccination coverage, which could predispose the area to outbreaks of vaccine-preventable disease.PMID:37659897 | DOI:10.1016/j.vaccine.2023.08.044
Source: Vaccine - September 2, 2023 Category: Allergy & Immunology Authors: Lily A Grills Abram L Wagner Source Type: research
Developmental and reproductive safety of Advax-CpG55.2 ™ adjuvanted COVID-19 and influenza vaccines in mice
Vaccine. 2023 Aug 31:S0264-410X(23)01007-1. doi: 10.1016/j.vaccine.2023.08.053. Online ahead of print.ABSTRACTSpikoGen® is a recombinant spike protein vaccine against COVID-19 that obtained marketing authorization in the Middle East on October 6th, 2021, becoming the first adjuvanted protein-based COVID-19 vaccine of its type to achieve approval. SpikoGen® vaccine utilizes a unique adjuvant Advax-CpG55.2, which comprises delta inulin and CpG55.2 oligonucleotide, a synthetic human toll-like receptor (TLR)-9 agonist. As part of a safety assessment, developmental and reproductive toxicity (DART) studies were undertaken in m...
Source: Vaccine - September 2, 2023 Category: Allergy & Immunology Authors: Isaac G Sakala Yoshikazu Honda-Okubo Nikolai Petrovsky Source Type: research
Rheumatoid arthritis and older age are associated with lower humoral and cellular immune response to primary series COVID-19 mRNA vaccine
CONCLUSIONS: These data indicate lower COVID-19 mRNA vaccine-induced antibody levels in persons with RA compared to individuals without RA, likely partially attributable to immune suppressive medications. At the same time, older age is associated with lower antibody and cellular immune response to COVID-19 vaccines.PMID:37659895 | DOI:10.1016/j.vaccine.2023.08.033
Source: Vaccine - September 2, 2023 Category: Allergy & Immunology Authors: Holly M Dudley Megan O'Mara Ann Auma Jenny Gong Yael Ross Natalie Gurevich Sarah Carbone Alex Reihs Ynez Nguyen Grace A McComsey Yi Cao Alejandro B Balazs Larraine Gordesky Michael Payne Nora Singer Lenche Kostadinova Brigid Wilson David A Zidar Christoph Source Type: research
Challenges & amp; opportunities for the epidemiological evaluation of the effects of COVID-19 vaccination on reproduction and pregnancy
Vaccine. 2023 Aug 31:S0264-410X(23)00964-7. doi: 10.1016/j.vaccine.2023.08.032. Online ahead of print.NO ABSTRACTPMID:37659894 | DOI:10.1016/j.vaccine.2023.08.032
Source: Vaccine - September 2, 2023 Category: Allergy & Immunology Authors: Annette K Regan Deshayne B Fell Lauren A Wise Gabriela Vazquez-Benitez Siri E H åberg Comfort Ogar Jennifer J Yland Amelia K Wesselink Ousseny Zerbo Source Type: research
TWiV 1040: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-CoV-2 specific humoral and cellular immune responses after contralateral and ipsilateral COVID-19 vaccination, Pfizer and BioNTech ...
Source: This Week in Virology - MP3 Edition - September 2, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
This article represents a comprehensive review of the function, structure and inhibition of SARS-CoV and -CoV-2 Mpro, including structure-activity relationships, protein-inhibitor interactions and clinical trial status.PMID:37659195 | DOI:10.1016/j.ejmech.2023.115772
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Xin Li Yongcheng Song Source Type: research
Operational strategies to deal with the COVID-19 emergency: recommendations from the Italian national society SIAGASCOT following the introduction of vaccines against the SARS-CoV-2 infection
ConclusionsThis document presents national-wide recommendations for managing patients eligible to undergo elective orthopaedic surgery with the beginning of the vaccination campaign. This paper could be the basis for similar documents adapted to the local healthcare systems in other countries.Level of evidenceLevel IV.
Source: Musculoskeletal Surgery - September 2, 2023 Category: Orthopaedics Source Type: research
Challenges in Estimating Effectiveness of 2 Doses of COVID-19 Vaccines Beyond 6 Months in England
Am J Epidemiol. 2023 Sep 1:kwad179. doi: 10.1093/aje/kwad179. Online ahead of print.NO ABSTRACTPMID:37656609 | DOI:10.1093/aje/kwad179
Source: Am J Epidemiol - September 1, 2023 Category: Epidemiology Authors: Elsie M F Horne William J Hulme Ruth H Keogh Tom M Palmer Elizabeth J Williamson Edward P K Parker Venexia M Walker Rochelle Knight Yinghui Wie Kurt Taylor Louis Fisher Jessica Morley Amir Mehrkar Iain Dillingham Sebastian Bacon Ben Goldacre Jonathan A C Source Type: research
Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
EClinicalMedicine. 2023 Jul 21;62:102107. doi: 10.1016/j.eclinm.2023.102107. eCollection 2023 Aug.ABSTRACTBACKGROUND: Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs.METHODS: This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- and in-patients followed at 3-, 6-, and 12-month from diagnosis, with assessment of clinical and biochemical features, antibody (Ab) response, Variant o...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Elisa Gentilotti Anna G órska Adriana Tami Roy Gusinow Massimo Mirandola Jes ús Rodríguez Baño Zaira R Palacios Baena Elisa Rossi Jan Hasenauer Iris Lopes-Rafegas Elda Righi Natascia Caroccia Salvatore Cataudella Zeno Pasquini Thomas Osmo Lidia Del Pi Source Type: research
Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
CONCLUSIONS: This review identifies many of the factors that influence a person's decision to take part in a vaccine trial, and these reflect findings from reviews that examine trials more broadly. However, we also recognise some factors that become more important in connection with a vaccine trial in the context of a pandemic or epidemic. These factors include the potential stigma of taking part, the possible adverse effects of a vaccine, the added motivation for helping society, the role of community leaders in trial dissemination, and the level of trust placed in governments and companies developing vaccines. These spec...
Source: Cochrane Database of Systematic Reviews - September 1, 2023 Category: General Medicine Authors: Pauline Meskell Linda M Biesty Maura Dowling Kevin Roche Elaine Meehan Claire Glenton Declan Devane Sasha Shepperd Andrew Booth Rebecca Cox Xin Hui S Chan Catherine Houghton Source Type: research
