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Vaccination: Covid Vaccine

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Total 26665 results found since Jan 2013.

Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy
Cell Mol Immunol. 2023 Sep 5. doi: 10.1038/s41423-023-01080-3. Online ahead of print.ABSTRACTSolid organ transplant (SOT) recipients receive immunosuppressive drugs (ISDs) and are susceptible to developing severe COVID-19. Here, we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients (n = 136) treated with different ISDs. We demonstrate that a combination of a calcineurin inhibitor (CNI), mycophenolate mofetil (MMF), and prednisone (Pred) treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular response. Such defects have clinical consequences bec...
Source: Cellular and Molecular Immunology - September 4, 2023 Category: Molecular Biology Authors: Qi Chen Adeline Chia Shou Kit Hang Amy Lim Wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti Source Type: research

Understanding low COVID-19 booster uptake among US adults
CONCLUSIONS: Improvement in booster uptake is necessary for optimal public health in the United States. The development of vaccines against SARS-CoV-2 occurred at an unprecedented speed, but vaccine uptake remains among the greatest current public health challenges as updated boosters continue to be developed and made available to the public. Interventions to improve vaccination rates require a variety of approaches.PMID:37666694 | DOI:10.1016/j.vaccine.2023.08.080
Source: Vaccine - September 4, 2023 Category: Allergy & Immunology Authors: Elizabeth T Jacobs Felina M Cordova-Marks Leslie V Farland Kacey C Ernst Jennifer G Andrews Sage Vu Kelly M Heslin Collin Catalfamo Zhao Chen Kristen Pogreba-Brown Source Type: research

Correlates of COVID-19 vaccine coverage in Arkansas: Results from a weighted random sample survey
Vaccine. 2023 Sep 1:S0264-410X(23)01039-3. doi: 10.1016/j.vaccine.2023.08.075. Online ahead of print.ABSTRACTWe assessed COVID-19 vaccination (≥1 dose) status as influenced by sociodemographic factors (i.e., age, gender, race/ethnicity, education, income, and parent or guardian status), healthcare provider recommendation, and personal vaccine hesitancy among Arkansas residents in October 2022. We asked: did the likelihood of vaccination differ across sociodemographic groups of Arkansas during this period of the pandemic? Is COVID-19 vaccination associated with recommendations from healthcare providers and/or COVID-19 vac...
Source: Vaccine - September 4, 2023 Category: Allergy & Immunology Authors: Don E Willis Ramey Moore Jennifer A Andersen Ji Li James P Selig Joshua C McKinnon Morgan Gurel-Headley Sharon Reece Pearl A McElfish Source Type: research

Timeline kinetics of protective immunity to SARS-CoV-2 upon primary vaccination and humoral response to variants after booster dose
In this study, we evaluated humoral reactivity kinetics from before the first dose to 180 days after the third booster dose in different schedules in a well-controlled health worker cohort. Among the 2,506 employees, the first 500 vaccinated health workers were invited to participate. The third booster dose was administered 8 months after the first dose. Among the invited participants, 470 were included in the study; 258 received inactivated vaccine CoronaVac (VAC group) and 212 received viral vector vaccine ChAdOx1 (AZV group). The groups were homogeneous in terms of age and sex. 347 participants were followed up after th...
Source: Vaccine - September 4, 2023 Category: Allergy & Immunology Authors: Maria da Penha Gomes Gouvea Ketty Lysie Libardi Lira Machado Yasmin Gurtler Pinheiro de Oliveira Isac Ribeiro Moulaz Allan Gon çalves Henriques Thayn á Martins Gouveia Beatriz Paoli Thompson Karen Evelin Monlevade Lan ça Sabrina de Souza Ramos Gabriela Source Type: research

Confirmed cases of COVID-19 after vaccination against COVID in health personnel in Bogot á, Colombia
CONCLUSIONS: A recent epidemiological study involving 12,364 health workers with a mean age of 38 years quantifies the protection in six months from the vaccine. The presence of antibodies was associated with 83 % protection against active SARS-CoV-2 infection (PCR positivity during the study period), which confirms the existence of protective Immunity at levels comparable to those obtained by the approved vaccines; our study found effectiveness of 92.6 %. Higher than that found in this study, possibly explained by the characteristics of the individuals included.PMID:37661532 | DOI:10.1016/j.vaccine.2023.07.078
Source: Vaccine - September 4, 2023 Category: Allergy & Immunology Authors: Alexandra Porras-Ram írez Rafael S ánchez-París Walter L ópez-Devia Zuly Moreno-Perilla Roberto Jurado-Zambrano Carlos Luna-Jaspe Caina Carlos Sefair Nicol ás Ramos Miguel Otero-Cadena Roc ío Lievano Source Type: research

Antiviral therapy of coronavirus disease 2019 (COVID-19)
J Formos Med Assoc. 2023 Sep 2:S0929-6646(23)00342-X. doi: 10.1016/j.jfma.2023.08.029. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has reached a turning point. The non-pharmaceutical interventions for preventing COVID-19 are lifting. Vaccination uptake is increasing in general, but this strategy is continuously challenged by the rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Of note, the Omicron subvariants spread globally for at least one year, and the most recently developed subvariants show strong immune evasion to preexisting immunity, either from pre...
Source: J Formos Med Assoc - September 4, 2023 Category: General Medicine Authors: Pao-Yu Chen Jann-Tay Wang Shan-Chwen Chang Source Type: research

"In the beginning, I said I wouldn't get it.": Hesitant adoption of the COVID-19 vaccine in remote Alaska between November 2020 and 2021
Soc Sci Med. 2023 Aug 30;334:116197. doi: 10.1016/j.socscimed.2023.116197. Online ahead of print.ABSTRACTAchieving sufficient COVID-19 vaccination coverage has been hindered in many areas by vaccine hesitancy. Many studies based on large survey samples have characterized vaccine refusal, but there are fewer in-depth qualitative studies that explore hesitant adoption: the middle-ground between vaccine acceptance and refusal, and how individuals may move across this continuum depending on their lived experience. For this paper, we use the narratives of 25 adults living in off-road, predominately Alaska Native communities to ...
Source: Rural Remote Health - September 4, 2023 Category: Rural Health Authors: Laura Eichelberger Amanda Hansen Patricia Cochran Ruby Fried Micah Hahn Source Type: research

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