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Vaccination: Covid Vaccine
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Total 26665 results found since Jan 2013.
Integrated Immunopeptidomics and Proteomics Study of SARS-CoV-2 Infected Calu-3 Cells Reveals Dynamic Changes in Allele-specific HLA Abundance and Antigen Presentation
We present an integrated immunopeptidomics and proteomics study of SARS-CoV-2 infection to comprehensively decipher the changes in host cells in response to viral infection. Immunopeptidomics analysis identified viral antigens presented by host cells through both Class I and Class II MHC system for recognition by the adaptive immune system. The host proteome changes were characterized by quantitative proteomics and glycoproteomics and from these data, the activation of TLR3-interferon pathway was identified. Glycosylation analysis of HLA proteins from the elution and flow-through of immunoprecipitation revealed that SARS-C...
Source: Molecular and Cellular Proteomics : MCP - September 14, 2023 Category: Molecular Biology Authors: Rui Chen Kelly M Fulton Anh Tran Diana Duque Kevin Kovalchik Etienne Caron Susan M Twine Jianjun Li Source Type: research
The re-emergence of influenza following the COVID-19 pandemic in Victoria, Australia, 2021 to 2022
ConclusionEnhanced testing for respiratory viruses during the COVID-19 pandemic provided a more complete picture of influenza virus transmission compared with previous seasons. Returned international travellers were important drivers of influenza reemergence, as were young adults, a group whose role has previously been under-recognised in the establishment of seasonal influenza epidemics. Targeting interventions, including vaccination, to these groups could reduce future influenza transmission.PMID:37707981 | DOI:10.2807/1560-7917.ES.2023.28.37.2300118
Source: Euro Surveill - September 14, 2023 Category: Infectious Diseases Authors: Catherine Ga Pendrey Janet Strachan Heidi Peck Ammar Aziz Jean Moselen Rob Moss Md Rezanur Rahaman Ian G Barr Kanta Subbarao Sheena G Sullivan Source Type: research
COVID-19 transmission driven by age-group mathematical model in Shijiazhuang City of China
CONCLUSIONS: Shijiazhuang epidemic was the first COVID-19 outbreak in the rural areas in Hebei Province of Northern China. The targeted interventions adopted in early 2021 were effective to halt the transmission due to the implementation of a strict and village-wide closure. However we found that age group profile and NPIs played critical rules to successfully contain Shijiazhuang epidemic, which should be considered by public health policies in rural areas of mainland China during the dynamic zero-COVID policy.PMID:37706095 | PMC:PMC10495604 | DOI:10.1016/j.idm.2023.08.004
Source: Rural Remote Health - September 14, 2023 Category: Rural Health Authors: Fengying Wei Ruiyang Zhou Zhen Jin Senzhong Huang Zhihang Peng Jinjie Wang Ximing Xu Xinyan Zhang Jun Xu Yao Bai Xiaoli Wang Bulai Lu Zhaojun Wang Jianguo Xu Source Type: research
Regulatory perspective for quality evaluation of lipid nanoparticle-based mRNA vaccines in China
Biologicals. 2023 Sep 12;84:101700. doi: 10.1016/j.biologicals.2023.101700. Online ahead of print.ABSTRACTIn recent years, urgent unmet medical needs due to the COVID-19 pandemic have accelerated the application of mRNA technology in vaccine development, leading to some of the first approvals of mRNA vaccines in human history by regulatory agencies around the world. For market authorization, comprehensive chemistry, manufacturing and control (CMC) information is required to assure the safety and quality consistency of mRNA vaccines. Evaluating mRNA vaccines for new virus variants poses a challenge for regulators, given the...
Source: Biologicals : Journal of the International Association of Biological Standardization - September 14, 2023 Category: Biotechnology Authors: Jiaqi Lu Wei Wei Wu He Source Type: research
The re-emergence of influenza following the COVID-19 pandemic in Victoria, Australia, 2021 to 2022
ConclusionEnhanced testing for respiratory viruses during the COVID-19 pandemic provided a more complete picture of influenza virus transmission compared with previous seasons. Returned international travellers were important drivers of influenza reemergence, as were young adults, a group whose role has previously been under-recognised in the establishment of seasonal influenza epidemics. Targeting interventions, including vaccination, to these groups could reduce future influenza transmission.PMID:37707981 | DOI:10.2807/1560-7917.ES.2023.28.37.2300118
Source: Euro Surveill - September 14, 2023 Category: Infectious Diseases Authors: Catherine Ga Pendrey Janet Strachan Heidi Peck Ammar Aziz Jean Moselen Rob Moss Md Rezanur Rahaman Ian G Barr Kanta Subbarao Sheena G Sullivan Source Type: research
Regulatory perspective for quality evaluation of lipid nanoparticle-based mRNA vaccines in China
Biologicals. 2023 Sep 12;84:101700. doi: 10.1016/j.biologicals.2023.101700. Online ahead of print.ABSTRACTIn recent years, urgent unmet medical needs due to the COVID-19 pandemic have accelerated the application of mRNA technology in vaccine development, leading to some of the first approvals of mRNA vaccines in human history by regulatory agencies around the world. For market authorization, comprehensive chemistry, manufacturing and control (CMC) information is required to assure the safety and quality consistency of mRNA vaccines. Evaluating mRNA vaccines for new virus variants poses a challenge for regulators, given the...
Source: Biologicals : Journal of the International Association of Biological Standardization - September 14, 2023 Category: Biotechnology Authors: Jiaqi Lu Wei Wei Wu He Source Type: research
Effects of the glycosylation of the receptor binding domain (RBD dimer)-based Covid-19 vaccine (ZF2001) on its humoral immunogenicity and immunoreactivity
Int J Biol Macromol. 2023 Sep 12;253(Pt 3):126874. doi: 10.1016/j.ijbiomac.2023.126874. Online ahead of print.ABSTRACTThe SARS-CoV-2 spike protein receptor-binding domain (RBD), which is a key target for the development of SARS-CoV-2 neutralizing antibodies and vaccines, mediates the binding of the host receptor angiotensin-converting enzyme 2 (ACE2). However, the high heterogeneity of RBD glycoforms may lead to an incomplete neutralization effect and impact the immunogenicity of RBD-based vaccines (Ye et al., 2021). Here, our data suggested that the glycosylation significantly affected the humoral immunogenicity and immun...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Xueqing Wang Lulu Shi Yirong Wang Jia Chen Zelan Yang Chenglong Liu Xiaomei Liu Yang Li Can Zhang Anhui Sun Huan Yan Hui Sun Source Type: research
Post-pandemic modeling of COVID-19: Waning immunity determines recurrence frequency
Math Biosci. 2023 Sep 12:109067. doi: 10.1016/j.mbs.2023.109067. Online ahead of print.ABSTRACTThere are many factors in the current phase of the COVID-19 pandemic that signal the need for new modeling ideas. In fact, most traditional infectious disease models do not address adequately the waning immunity, in particular as new emerging variants have been able to brake the immune shield acquired either by previous infection by a different strain of the virus, or by inoculation of vaccines not effective for the current variant. Furthermore, in a post-pandemic landscape in which reporting is no longer a default, it is impossi...
Source: Mathematical Biosciences - September 14, 2023 Category: Statistics Authors: D Calvetti E Somersalo Source Type: research
COVID-19 transmission driven by age-group mathematical model in Shijiazhuang City of China
CONCLUSIONS: Shijiazhuang epidemic was the first COVID-19 outbreak in the rural areas in Hebei Province of Northern China. The targeted interventions adopted in early 2021 were effective to halt the transmission due to the implementation of a strict and village-wide closure. However we found that age group profile and NPIs played critical rules to successfully contain Shijiazhuang epidemic, which should be considered by public health policies in rural areas of mainland China during the dynamic zero-COVID policy.PMID:37706095 | PMC:PMC10495604 | DOI:10.1016/j.idm.2023.08.004
Source: Rural Remote Health - September 14, 2023 Category: Rural Health Authors: Fengying Wei Ruiyang Zhou Zhen Jin Senzhong Huang Zhihang Peng Jinjie Wang Ximing Xu Xinyan Zhang Jun Xu Yao Bai Xiaoli Wang Bulai Lu Zhaojun Wang Jianguo Xu Source Type: research
Lipid nanoparticle-based COVID-19 vaccines: Ensuring pharmaceutical stability, safety, and efficacy
Am J Health Syst Pharm. 2023 Sep 14:zxad221. doi: 10.1093/ajhp/zxad221. Online ahead of print.ABSTRACTIn an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.PMID:37707445 | DOI:10.1093/ajhp/zxad221
Source: American Journal of Health-System Pharmacy : AJHP - September 14, 2023 Category: Drugs & Pharmacology Authors: David F Driscoll Source Type: research
Post-pandemic modeling of COVID-19: Waning immunity determines recurrence frequency
Math Biosci. 2023 Sep 12:109067. doi: 10.1016/j.mbs.2023.109067. Online ahead of print.ABSTRACTThere are many factors in the current phase of the COVID-19 pandemic that signal the need for new modeling ideas. In fact, most traditional infectious disease models do not address adequately the waning immunity, in particular as new emerging variants have been able to brake the immune shield acquired either by previous infection by a different strain of the virus, or by inoculation of vaccines not effective for the current variant. Furthermore, in a post-pandemic landscape in which reporting is no longer a default, it is impossi...
Source: Mathematical Biosciences - September 14, 2023 Category: Statistics Authors: D Calvetti E Somersalo Source Type: research
Vaccination coverage survey of children aged 1-3 years in Beijing, China, 2005-2021
CONCLUSION: The coverage level and service quality of routine immunization in Beijing were relatively high. However, as influenced by COVID-19 epidemics, both on-time and in-time vaccination rates decreased significantly, except for BCG and HepB. Under the background of COVID-19 pandemic, the keys to maintain high level of vaccination coverage include flexible immunization service time to ensure the guardians bringing their children for vaccination timely, and more attention from providers to the doses after children's first birthday.PMID:37709591 | DOI:10.1016/j.vaccine.2023.08.015
Source: Vaccine - September 14, 2023 Category: Allergy & Immunology Authors: Wen-Yan Ji Dong-Lei Liu Rui Yu Liang Miao Qian-Li Yuan Luo-Dan Suo Jian-Ping Yu Source Type: research
Post-pandemic modeling of COVID-19: Waning immunity determines recurrence frequency
Math Biosci. 2023 Sep 12:109067. doi: 10.1016/j.mbs.2023.109067. Online ahead of print.ABSTRACTThere are many factors in the current phase of the COVID-19 pandemic that signal the need for new modeling ideas. In fact, most traditional infectious disease models do not address adequately the waning immunity, in particular as new emerging variants have been able to brake the immune shield acquired either by previous infection by a different strain of the virus, or by inoculation of vaccines not effective for the current variant. Furthermore, in a post-pandemic landscape in which reporting is no longer a default, it is impossi...
Source: Mathematical Biosciences - September 14, 2023 Category: Statistics Authors: D Calvetti E Somersalo Source Type: research
