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Therapy: Neoadjuvant Therapy
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Total 9957 results found since Jan 2013.
RANK expression as an independent predictor for response to neoadjuvant chemotherapy in luminal-like breast cancer - a translational insight from the GeparX trial
CONCLUSIONS: We report RANK expression to be an independent predictive biomarker for response to NACT in luminal-like breast cancer patients.PMID:37725572 | DOI:10.1158/1078-0432.CCR-23-1801
Source: Clinical Genitourinary Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Theresa Link Jens-Uwe Blohmer Wolfgang D Schmitt Jan Dominik Kuhlmann Marianne Just Michael Untch Oliver Stotzer Peter A Fasching Marc Thill Mattea Reinisch Andreas Schneeweiss Pauline Wimberger Sabine Seiler Jens Huober Christian Jackisch Kerstin Rhiem C Source Type: research
Consultation on UTUC II Stockholm 2022: diagnostic and prognostic methods —what’s around the corner?
ConclusionCurrent diagnostic methods for UTUC have shortcomings, especially concerning prognostication, which is important for personalized treatment decisions. There are several upcoming methods that may be of interest for UTUC. Most have been studied for urothelial carcinoma of the bladder, and it is important to keep in mind that UTUC is a different entity and not all methods are adaptable or applicable to UTUC.
Source: World Journal of Urology - September 19, 2023 Category: Urology & Nephrology Source Type: research
Oncological recurrence following pathological complete response after neoadjuvant treatment in patients with esophageal cancer - a retrospective cohort study
CONCLUSION: Distant recurrence is the predominant site of treatment failure in patients with pCR and non-pCR grade 1a regression, whereby recurrence rates are much higher in patients with non-pCR.PMID:37721586 | DOI:10.1007/s00423-023-03100-2
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Julian Hipp Jasmina Kuvendjiska Hans Christian Hillebrecht Stephan Herrmann Sylvia Timme-Bronsert Stefan Fichtner-Feigl Jens Hoeppner Markus K Diener Source Type: research
Real-world evidence of neoadjuvant chemotherapy for breast cancer treatment in a Brazilian multicenter cohort: Correlation of pathological complete response with overall survival
CONCLUSION: The pCR rate and its prognostic value varied across BC subtypes. In our study, pCR could be used as a surrogate of favorable clinical outcome, as it was associated with higher OS and DFS rates.PMID:37722319 | DOI:10.1016/j.breast.2023.103577
Source: Breast - September 18, 2023 Category: Cancer & Oncology Authors: Marcelo Antonini Andr é Mattar Fernanda Grace Bauk Richter Gabriel Duque Pannain Marina Di ógenes Teixeira Andressa Gon çalves Amorim Odair Ferraro Reginaldo Coelho Guedes Lopes Luiz Henrique Gebrim Juliana Monte Real Source Type: research
Artificial intelligence in breast imaging: potentials and challenges
Phys Med Biol. 2023 Sep 18. doi: 10.1088/1361-6560/acfade. Online ahead of print.ABSTRACTBreast cancer, which is the most common type of malignant tumor among humans, is a leading cause of death in females. Standard treatment strategies, including neoadjuvant chemotherapy, surgery, postoperative chemotherapy, targeted therapy, endocrine therapy, and radiotherapy, are tailored for individual patients. Such personalized therapies have tremendously reduced the threat of breast cancer in females. Furthermore, early imaging screening plays an important role in reducing the treatment cycle and improving breast cancer prognosis. ...
Source: Physics in Medicine and Biology - September 18, 2023 Category: Physics Authors: Jiawei Li Danli Sheng Jiangang Chen Chao You Shuai Liu Huixiong Xu Cai Chang Source Type: research
Real-world evidence of neoadjuvant chemotherapy for breast cancer treatment in a Brazilian multicenter cohort: Correlation of pathological complete response with overall survival
CONCLUSION: The pCR rate and its prognostic value varied across BC subtypes. In our study, pCR could be used as a surrogate of favorable clinical outcome, as it was associated with higher OS and DFS rates.PMID:37722319 | DOI:10.1016/j.breast.2023.103577
Source: Breast - September 18, 2023 Category: Cancer & Oncology Authors: Marcelo Antonini Andr é Mattar Fernanda Grace Bauk Richter Gabriel Duque Pannain Marina Di ógenes Teixeira Andressa Gon çalves Amorim Odair Ferraro Reginaldo Coelho Guedes Lopes Luiz Henrique Gebrim Juliana Monte Real Source Type: research
Single Fraction vs. Fractionated Preoperative Radiosurgery for Resected Brain Metastases: a PROPS-BM International Multicenter Cohort Study
CONCLUSIONS: Preoperative MF-SRS was associated with significantly reduced risk of cavity LR in both the unmatched and PSM analyses. There was no difference in ARE, MD, or OS based on fractionation. MF-SRS may be a preferred option for neoadjuvant RT of resected brain metastases. Additional confirmatory studies are needed. A phase III randomized trial of single fraction preoperative vs. postoperative SRS (NRG-BN012) is ongoing (NCT05438212).PMID:37717787 | DOI:10.1016/j.ijrobp.2023.09.012
Source: Health Physics - September 17, 2023 Category: Physics Authors: Roshan S Prabhu Tobi Akinyelu Zachary K Vaslow Jennifer K Matsui Neda Haghighi Tu Dan Mark V Mishra Erin S Murphy Susan Boyles Haley K Perlow Joshua D Palmer Cristian Udovicich Toral R Patel Zabi Wardak Graeme F Woodworth Alexander Ksendzovsky Kailin Yang Source Type: research
Pathologic response to neoadjuvant chemotherapy in ovarian cancer and its association with outcome: A surrogate marker of survival
CONCLUSIONS: We validate a three-tier CRS for assessment of pathologic response to NACT in OC and demonstrate its prognostic independence of BRCA status or neoadjuvant bevacizumab use. Improving pR rates may be a useful goal of NACT in OC with the expectation of improved survival. The CRS may be a useful endpoint in clinical trials in OC.PMID:37716223 | DOI:10.1016/j.ygyno.2023.09.002
Source: Gynecologic Oncology - September 16, 2023 Category: Cancer & Oncology Authors: Leah A Marsh Teresa H Kim Mingyan Zhang Kari Kubalanza Charisse Liz Treece Dana Chase Sanaz Memarzadeh Ritu Salani Beth Karlan Jianyu Rao Gottfried E Konecny Source Type: research
Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research
