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Therapy: Neoadjuvant Therapy

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Total 9957 results found since Jan 2013.

Sequential Chemotherapy Followed by Radiotherapy Versus Concurrent Chemo-Radiation in Muscle Invasive Bladder Cancer
Urol J. 2023 Jul 31. doi: 10.22037/uj.v20i.7525. Online ahead of print.ABSTRACTBladder cancer is diagnosed at older age compared to all other known cancer types. Radical cystectomy after neoadjuvant chemotherapy or tri-modality treatment (consist of TURB, concurrent chemo-radiation) are the standard treatments. Many of the patients cannot receive tri-modality treatment (concurrent chemo-radiation) because of medical comorbidities. The present study assessed the results of sequential use of chemotherapy and radiotherapy versus concurrent use of them in 266 muscle invasive bladder cancer patients. The results showed similar ...
Source: Urology Journal - September 5, 2023 Category: Urology & Nephrology Authors: Mohammad Hasan Larizadeh Fateme Arabnejad Mohammad Reza Ebadzadeh Source Type: research

Immune checkpoint inhibitor therapy in neoadjuvant and adjuvant treatment for cancer: A paradigm shift in the treatment of resectable gastrointestinal cancer 3)A paradigm shift in the treatment of colorectal cancer
Int J Clin Oncol. 2023 Sep 5. doi: 10.1007/s10147-023-02387-x. Online ahead of print.ABSTRACTImmune checkpoint inhibitors, such as anti-programmed cell death-1, programmed cell death ligand-1, and cytotoxic T-lymphocyte antigen-4 monoclonal antibodies, have been notably effective in various types of cancers. Mismatch repair deficiency and microsatellite instability-high tumors have been established as striking biomarkers for response to immune checkpoint inhibitors. These biomarkers show a higher mutational burden, have cancer-associated neoantigens, and dense immune cell infiltration, which generates a robust immune respo...
Source: Clinical Colorectal Cancer - September 5, 2023 Category: Cancer & Oncology Authors: Kotoe Oshima Kentaro Yamazaki Source Type: research

Application of personalized spacers made with 3D-printed mold in the two-stage procedure for periarticular infection
CONCLUSIONS: This case report describes limb-salvage surgery following distal femoral resection for periarticular infection. The personalized spacers prepared by a 3D-printed mold can be used in periarticular infection after long bone resection, mega-prosthetic infection, or limb-salvage surgery for temporary joints in small children.PMID:37667927 | DOI:10.26355/eurrev_202308_33402
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: G-X Qu C-L Zhang X-H Du W-T Yao Source Type: research

Immune checkpoint inhibitor therapy in neoadjuvant and adjuvant treatment for cancer: A paradigm shift in the treatment of resectable gastrointestinal cancer 3)A paradigm shift in the treatment of colorectal cancer
Int J Clin Oncol. 2023 Sep 5. doi: 10.1007/s10147-023-02387-x. Online ahead of print.ABSTRACTImmune checkpoint inhibitors, such as anti-programmed cell death-1, programmed cell death ligand-1, and cytotoxic T-lymphocyte antigen-4 monoclonal antibodies, have been notably effective in various types of cancers. Mismatch repair deficiency and microsatellite instability-high tumors have been established as striking biomarkers for response to immune checkpoint inhibitors. These biomarkers show a higher mutational burden, have cancer-associated neoantigens, and dense immune cell infiltration, which generates a robust immune respo...
Source: Clinical Colorectal Cancer - September 5, 2023 Category: Cancer & Oncology Authors: Kotoe Oshima Kentaro Yamazaki Source Type: research

Sequential Chemotherapy Followed by Radiotherapy Versus Concurrent Chemo-Radiation in Muscle Invasive Bladder Cancer
Urol J. 2023 Jul 31. doi: 10.22037/uj.v20i.7525. Online ahead of print.ABSTRACTBladder cancer is diagnosed at older age compared to all other known cancer types. Radical cystectomy after neoadjuvant chemotherapy or tri-modality treatment (consist of TURB, concurrent chemo-radiation) are the standard treatments. Many of the patients cannot receive tri-modality treatment (concurrent chemo-radiation) because of medical comorbidities. The present study assessed the results of sequential use of chemotherapy and radiotherapy versus concurrent use of them in 266 muscle invasive bladder cancer patients. The results showed similar ...
Source: Urology Journal - September 5, 2023 Category: Urology & Nephrology Authors: Mohammad Hasan Larizadeh Fateme Arabnejad Mohammad Reza Ebadzadeh Source Type: research

Systemic treatments for resectable carcinoma of the esophagus
World J Gastroenterol. 2023 Aug 14;29(30):4628-4641. doi: 10.3748/wjg.v29.i30.4628.ABSTRACTOne of the most prevalent malignancies in the world is esophageal cancer (EC). The 5-year survival rate of EC remains pitiful despite treatment advancements. Neoadjuvant chemoradiotherapy in conjunction with esophagectomy is the standard of care for patients with resectable disease. The pathological complete response rate, however, is not acceptable. A distant metastasis or a locoregional recurrence will occur in about half of the patients. To increase the clinical effectiveness of therapy, it is consequently vital to investigate cut...
Source: World Journal of Gastroenterology - September 4, 2023 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research