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Cancer: Lung Cancer
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Total 37398 results found since Jan 2013.
Pneumonitis in Patients Receiving Thoracic Radiotherapy and Osimertinib: A Multi-Institutional Study
CONCLUSIONS: Although the overall rate of pneumonitis in patients receiving TRT and osimertinib was relatively low, there was a small risk of severe toxicity. The mean lung dose was associated with an increased risk of developing pneumonitis. These findings inform decision-making for patients and providers.PMID:37732171 | PMC:PMC10507641 | DOI:10.1016/j.jtocrr.2023.100559
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Leou Ismael Banla Alice Tzeng John P Baillieul Melin J Kandekhar Kelly J Fitzgerald Jaclyn LoPiccolo Holly A Poitras Daniel E Soto Julia K Rotow Lisa Singer Henning Willers David E Kozono Pasi A Janne Raymond H Mak Zofia Piotrowska Florence K Keane Benjam Source Type: research
Subtype of SCLC Is an Intrinsic and Persistent Feature Through Systemic Treatment
CONCLUSIONS: Subtype of SCLC generally remains the same after acquiring chemotherapy resistance. Plasticity was observed with rare cases switching from NEUROD1-predominant to ASC1-predominant SCLC. Resubtyping is unnecessary for the consideration of novel subtype-specific targeted agents, except cases with NEUROD1-predominant subtype.PMID:37731627 | PMC:PMC10507151 | DOI:10.1016/j.jtocrr.2023.100561
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Ying-Chun Lo Joel Rivera-Concepcion George Vasmatzis Marie-Christine Aubry Konstantinos Leventakos Source Type: research
Left epigastric isolated tumor fed by the inferior phrenic artery diagnosed as ectopic hepatocellular carcinoma: A case report
CONCLUSION: This asymptomatic ectopic HCC case described achieved an excellent result due to early detection, radical resection, and systematic surveillance.PMID:37731571 | PMC:PMC10507550 | DOI:10.12998/wjcc.v11.i26.6231
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hong-Bo Liu Li-Hua Zhao Yong-Jian Zhang Zhi-Feng Li Lei Li Qian-Peng Huang Source Type: research
Albendazole induces an anti-tumor effect and potentiates PD-L1 blockade immunotherapy
CONCLUSION: ABZ inhibits melanoma growth and metastasis. Moreover, ABZ synergized with PD-L1 blockade mediates tumor regression.PMID:37730912 | DOI:10.1007/s00432-023-05415-5
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Weinan Zhang Zhiqiang He Fucheng Liang Jie Gong Liuchang Tan Juan Yang Siji Song Luoyingzi Xie Yuangang Lu Source Type: research
Immune evasion of G-CSF and GM-CSF in lung cancer
Tuberc Respir Dis (Seoul). 2023 Sep 20. doi: 10.4046/trd.2023.0037. Online ahead of print.ABSTRACTTumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and f...
Source: Respiratory Care - September 20, 2023 Category: Respiratory Medicine Authors: Yeonhee Park Chauek Chung Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Technology in Cancer Research and Treatment - September 20, 2023 Category: Cancer & Oncology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
Coevolution-based computational approach to detect resistance mechanism of epidermal growth factor receptor
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119592. doi: 10.1016/j.bbamcr.2023.119592. Online ahead of print.ABSTRACTTyrosine kinase epidermal growth factor receptor (EGFR) correlates the neoplastic cell metastasis, angiogenesis, neoplastic incursion, and apoptosis. Due to the involvement of EGFR in these biological processes, it becomes a most potent target for treating non-small cell lung cancer (NSCLC). The tyrosine kinase inhibitors (TKI) have endorsed high efficacy and anticipation to patients but unfortunately, within a year of treatment, drug targets develop resistance due to mutations. The present study detected...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Gyan Prakash Rai Asheesh Shanker Source Type: research
MicroRNA biomarkers and their use in evaluating the prognosis of lung cancer
CONCLUSION: The three miRNA composites identified, namely hsa-mir-21, hsa-mir-141, and hsa-mir-490, have the potential to serve as novel prognostic biomarkers and therapeutic targets for lung cancer.PMID:37728700 | DOI:10.1007/s00432-023-05404-8
Source: Clinical Lung Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Ruijie Wu Bohan Zhang Mengju He Yani Kang Gong Zhang Source Type: research
Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma
CONCLUSIONS: The results indicate that promoting infiltration and activation of B cell populations could improve the long-term survival of LUAD patients, thereby offering a potential novel immunotherapeutic approach for LUAD. Besides, the promotion of cancer cell ferroptosis and upregulation of WDFY4 expression have been shown to induce the infiltration and activation of B cell populations. Furthermore, the overexpression of WDFY4 can significantly inhibit the growth of lung adenocarcinoma in vitro and in vivo, highlighting its potential as a target for immunotherapy in LUAD.PMID:37728413 | DOI:10.18632/aging.205042
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Ling Huang Lifan Zhong Ruxin Cheng Limei Chang Mingyan Qin Huaping Liang Zhongkai Liao Source Type: research
Immune evasion of G-CSF and GM-CSF in lung cancer
Tuberc Respir Dis (Seoul). 2023 Sep 20. doi: 10.4046/trd.2023.0037. Online ahead of print.ABSTRACTTumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and f...
Source: Respiratory Care - September 20, 2023 Category: Respiratory Medicine Authors: Yeonhee Park Chauek Chung Source Type: research
CRISPR-mediated reversion of oncogenic KRAS mutation results in increased proliferation and reveals independent roles of Ras and mTORC2 in the migration of A549 lung cancer cells
Mol Biol Cell. 2023 Sep 20:mbcE23050152. doi: 10.1091/mbc.E23-05-0152. Online ahead of print.ABSTRACTAlthough the RAS oncogene has been extensively studied, new aspects concerning its role and regulation in normal biology and cancer continue to be discovered. Recently, others and we have shown that the mechanistic Target of Rapamycin Complex 2 (mTORC2) is a Ras effector in Dictyostelium and mammalian cells. mTORC2 plays evolutionarily conserved roles in cell survival and migration and has been linked to tumorigenesis. Since RAS is often mutated in lung cancer, we investigated whether a Ras-mTORC2 pathway contributes to enh...
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Alyssa N Werner Avani I Kumar Pascale G Charest Source Type: research
Coevolution-based computational approach to detect resistance mechanism of epidermal growth factor receptor
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119592. doi: 10.1016/j.bbamcr.2023.119592. Online ahead of print.ABSTRACTTyrosine kinase epidermal growth factor receptor (EGFR) correlates the neoplastic cell metastasis, angiogenesis, neoplastic incursion, and apoptosis. Due to the involvement of EGFR in these biological processes, it becomes a most potent target for treating non-small cell lung cancer (NSCLC). The tyrosine kinase inhibitors (TKI) have endorsed high efficacy and anticipation to patients but unfortunately, within a year of treatment, drug targets develop resistance due to mutations. The present study detected...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Gyan Prakash Rai Asheesh Shanker Source Type: research
The inherited KRAS-variant as a biomarker of Cetuximab Response in NSCLC
CONCLUSIONS/DISCUSSION: Although an overall survival advantage was not achieved in KRAS-variant patients, there is potential impact of cetuximab for this genetic subset of patients. In contrast, cetuximab seems to harm non-variant patients. These findings further support the importance of genetic patient selection in trials studying the addition of systemic agents to radiotherapy.PMID:37728512 | DOI:10.1158/2767-9764.CRC-23-0084
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Joanne B Weidhaas Chen Hu Ritsuko Komaki Gregory A Masters George R Blumenschein Joe Y Chang Bo Lu Adam P Dicker Jeffrey A Bogart Yolanda I Garces Samir Narayan Clifford G Robinson Vivek S Kavadi Joel S Greenberger Christopher D Koprowski James W Welsh El Source Type: research
Metastatic competency and tumor spheroid formation are independent cell states governed by RB in lung adenocarcinoma
Cancer Res Commun. 2023 Sep 20. doi: 10.1158/2767-9764.CRC-23-0172. Online ahead of print.ABSTRACTInactivation of the retinoblastoma (RB) tumor suppressor in lung adenocarcinoma is associated with the rapid acquisition of metastatic ability and the loss of lung cell lineage commitment. We previously showed that restoration of RB in advanced lung adenocarcinomas in the mouse was correlated with a decreased frequency of lineage de-committed tumors and overt metastases. To identify a causal relationship for RB and its role in reprogramming lineage commitment and reducing metastatic competency in lung adenocarcinoma, we develo...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Nelson F Freeburg Nia Peterson Dain A Ruiz Amy C Gladstein David M Feldser Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
