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Cancer: Lung Cancer
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Total 37398 results found since Jan 2013.
Effect of Yifei Qinghua Granule on the Tumor Microenvironment in Lung Cancer by Regulating the Inflammatory Pathway
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):118-124. doi: 10.14715/cmb/2023.69.8.18.ABSTRACTTo investigate the mechanism of action of inflammatory molecules regulating the tumor microenvironment and anti-tumor through Yifei Qinghua granules and phloroglucinol-containing serum intervening in the changes of tumor microenvironment in vitro in the co-culture of lung cancer cells and bone marrow cells. A549 lung adenocarcinoma cell line and ST2 bone marrow stromal cell line were selected and a transwell chamber was used to establish the co-culture system of the two kinds of cells. They were divided into normal saline, phl...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: LiHong Zhang Zhijiang Zhuang Liang Geng G E Wang Yun Cui Tongde Tian Sheng Wang Bian Shi Source Type: research
The novel small molecule BH3 mimetic nobiletin synergizes with vorinostat to induce apoptosis and autophagy in small cell lung cancer
Biochem Pharmacol. 2023 Sep 14:115807. doi: 10.1016/j.bcp.2023.115807. Online ahead of print.ABSTRACTSmall cell lung cancer (SCLC) is a highly lethal subtype of lung cancer with few therapeutic options; therefore, the identification of new targets and drugs with potent combination therapy is desirable. We previously screened BH3 mimetics from a natural product library, and in this study, we validated nobiletin as a BH3 mimetic. Specifically, we observed its combination potential and mechanism with vorinostat in SCLC in vitro and in vivo. The results showed that combination treatment with nobiletin and vorinostat reduced th...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Yu-Qian Li Fang Fan Yuan-Ru Wang Lu-Yao Li Ya-Jun Cao Si-Meng Gu Shuai-Shuai Liu Yue Zhang Jie Wang Lu Tie Yan Pan Hui-Fang Li Xue-Jun Li Source Type: research
Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors
CONCLUSION: In this study, we have explored luteolin as one of the active components of YQG, and may inhibit the proliferation and migration of A549 cells by decreasing the expression of AR and the regulation of phosphorylation at AR-binding sites.PMID:37716981 | PMC:PMC10504720 | DOI:10.1186/s40001-023-01302-4
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Xu Li Yeling Tang Pengchen Liang Miaomiao Sun Tian Li Zhiping Shen Shuang Sha Source Type: research
Nuclear factor kappa B expression in non-small cell lung cancer
Biomed Pharmacother. 2023 Sep 14;167:115459. doi: 10.1016/j.biopha.2023.115459. Online ahead of print.ABSTRACTIn this mini-review, we discuss the role of NF-κB, a proinflammatory transcription factor, in the expression of genes involved in inflammation, proliferation, and apoptosis pathways, and link it with prognosis of various human cancers, particularly non-small cell lung cancer (NSCLC). We and others have shown that NF-κB activity can be impacted by post-translational S-glutathionylation through reversible formation of a mixed disulfide bond between its cysteine residues and glutathione (GSH). Clinical data analysis...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Leilei Zhang Claudia M Ludden Alexander J Cullen Kenneth D Tew Andr é Luís Branco de Barros Danyelle M Townsend Source Type: research
Ciltacabtagene Autoleucel in Patients With Prior Allogeneic Stem Cell Transplant in the CARTITUDE-1 Study
CONCLUSION: Cilta-cel efficacy and safety were comparable between CARTITUDE-1 patients with and without prior alloSCT. Additional studies are needed to fully elucidate the suitability of CAR-T cell therapy in the post-alloSCT setting.PMID:37716872 | DOI:10.1016/j.clml.2023.08.012
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Myo Htut Binod Dhakal Adam D Cohen Thomas Martin Jesus G Berdeja Saad Z Usmani Mounzer Agha Carolyn C Jackson Deepu Madduri William Deraedt Enrique Zudaire Tzu-Min Yeh Xiaoying Xu Lida Pacaud Muhammad Akram Sundar Jagannath Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
The prognostic and immunological role of FKBP1A in an integrated muti-omics cancers analysis, especially lung cancer
CONCLUSION: In conclusion, FKBP1A exhibits differential expression in cancer, serves as a prognostic indicator, undergoes genetic alterations, and influences the tumor-immune microenvironment. These findings shed light on the multifaceted role of FKBP1A in cancer development and progression, suggesting its potential as a therapeutic target and guidance of clinical drugs selection, and provide valuable insights into patient prognosis for interventions based on pharmaceuticals.PMID:37715833 | DOI:10.1007/s00432-023-05362-1
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Yi Zhang Haifeng Xu Sainan Pi Huiqian Tan Bihui Huang Youpeng Chen Source Type: research
Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor
In conclusion, TCs can protect against lung tissue fibrosis by releasing HGF, a process dependent on HK2.PMID:37715611 | DOI:10.1111/1440-1681.13823
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Shaoyuan Zhang Linyi Sun Borong Chen Siyun Lin Jianmin Gu Lijie Tan Miao Lin Source Type: research
METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury
Clin Transl Med. 2023 Sep;13(9):e1389. doi: 10.1002/ctm2.1389.ABSTRACTNeutrophil extracellular traps (NETs), released by polymorphonuclear neutrophils (PMNs), exert a robust antimicrobial function in infectious diseases such as sepsis. NETs also contribute to the pathogenesis and exacerbation of sepsis. Although the lung is highly vulnerable to infections, few studies have explored the role of NETs in sepsis-induced acute lung injury (SI-ALI). We demonstrate that NETs induce SI-ALI via enhanced ferroptosis in alveolar epithelial cells. Our findings reveal that the excessive release of NETs in patients and mice with SI-ALI ...
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Hao Zhang Dan Wu Yanghanzhao Wang Kefang Guo Charles B Spencer Lilibeth Ortoga Mengdi Qu Yuxin Shi Yuwen Shao Zhiping Wang Juan P Cata Changhong Miao Source Type: research
Bisphenol A is more potent than bisphenol S in influencing the physiological and pathological functions of lungs via inducing lung fibrosis and stimulating metastasis
We examined the potential differences in toxicity between these compounds in lung cells in vitro and in vivo. Our toxicity mechanism studies on MRC5 and A549 cells exposed to BPA or BPS revealed that BPA induced actin filament abnormalities and activated epithelial-mesenchymal transition (EMT). This finding suggests an increased potential for lung fibrosis and metastasis in lung cancer. However, given that BPS was not detected at the administered dose and under the specific experimental conditions, the probability of these occurrences is considered minimal. Additionally, animal experiments confirmed that oral exposure to B...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Min Heui Yoo A-Ram Lee Woojin Kim Wook-Joon Yu Byoung-Seok Lee Source Type: research
Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors
ConclusionIn this study, we have explored luteolin as one of the active components of YQG, and may inhibit the proliferation and migration of A549 cells by decreasing the expression of AR and the regulation of phosphorylation at AR-binding sites.
Source: European Journal of Medical Research - September 16, 2023 Category: Research Source Type: research
Stereotactic Radiosurgery Results in Non-Small-Cell Lung Cancer Patients with Brain Metastases in the Era of Modern Systemic Treatment Agents
CONCLUSION: Using current systemic agents with radiotherapy for brain metastasis significantly affected post-radiotherapy intracranial progression-free survival.PMID:37712866 | DOI:10.5152/ThoracResPract.2023.23025
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Feyza Ya şar Daşgın Tar ı Kargıoğlu Aliye Arslan Ali Kerim Aksakal Binnur Dadak Fatma Bet ül Ayrak Ezgi G ökçe İpek Pinar Aral Gonca Alt ınışık İnan Y ılmaz Tezcan Source Type: research
The value of radiomics model based on ultrasound image features in the differentiation between minimal breast cancer and small benign breast masses
CONCLUSION: The radiomics model based on ultrasound image features has a satisfied predictive ability for small breast masses, and is expected to become a potential tool for the diagnosis of MBC, and it is a zero cost (in terms of patient participation and imaging time).PMID:37712556 | DOI:10.1002/jcu.23556
Source: Clinical Lung Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Shuyi Lyu Meiwu Zhang Baisong Zhang Jiazhen Zhu Libo Gao Yuqin Qiu Liu Yang Yan Zhang Source Type: research
