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Cancer: Lung Cancer
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Total 37398 results found since Jan 2013.
Long-course chemoradiation plus concurrent/sequential PD-1 blockade as neoadjuvant treatment for MMR-status-unscreened locally advanced rectal cancer: protocol of a multicentre, phase 2, randomised controlled trial (the POLAR-STAR trial)
BMJ Open. 2023 Sep 12;13(9):e069499. doi: 10.1136/bmjopen-2022-069499.ABSTRACTINTRODUCTION: Recent preclinical studies have discovered unique synergism between radiotherapy and immune checkpoint inhibitors, which has already brought significant survival benefit in lung cancer. In locally advanced rectal cancer (LARC), neoadjuvant radiotherapy plus immune checkpoint inhibitors have also achieved surprisingly high pathological complete response (pCR) rates even in proficient mismatch-repair patients. As existing researches are all phase 2, single-cohort trials, we aim to conduct a randomised, controlled trial to further clar...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Kai Pang Yun Yang Dan Tian Na Zeng Shun Cao Shen Ling Jiale Gao Pengfei Zhao Hao Wang Yuanyuan Kong Jie Zhang Guangyong Chen Wei Deng Zhigang Bai Lan Jin Guoju Wu Danyang Zhu Yue Wang Jiaolin Zhou Bin Wu Guole Lin Yi Xiao Zhidong Gao Yingjiang Ye Xin Wang Source Type: research
The predictive value of advanced lung cancer inflammation index for short-term outcomes and prognosis of colorectal cancer patients who underwent radical surgery
CONCLUSION: Lower ALI was associated with more postoperative complications, worse OS, and DFS for CRC patients who underwent radical surgery. Furthermore, ALI was an independent risk factor for overall complications, OS, and DFS. Surgeons should pay close attention to patients with low ALI before surgery and make clinical strategies cautiously.PMID:37700210 | DOI:10.1007/s10147-023-02410-1
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Bin Zhang Zi-Wei Li Yue Tong Chao Yuan Xiao-Yu Liu Zheng-Qiang Wei Wei Zhang Dong Peng Source Type: research
Nivolumab as maintenance therapy following platinum-based chemotherapy in EGFR-mutant lung cancer patients after tyrosine kinase inhibitor failure: A single-arm, open-label, phase 2 trial
CONCLUSION: Nivolumab maintenance following platinum-based chemotherapy did not show clinical benefits after EGFR-TKI failure in patients with EGFR-mutant NSCLC.PMID:37699785 | DOI:10.1111/1759-7714.15083
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Jiwon Kim Chang-Min Choi Wonjun Ji Jae Cheol Lee Source Type: research
Early mortality in German patients with lung cancer: risk factors associated with 30-and 60-day mortality
In this study, we aimed to assess risk factors for 30- and 60-day mortality in German lung cancer patients. In this retrospective cross-sectional analysis, we used data of lung cancer patients treated at LMU Hospital Munich between 2015 and 2019. We categorized patients into 30-day mortality, 60 day-mortality, and longer survival. We used Student's t-test and ANOVA to compare means and Chi2-test to compare frequencies. We used logistic regression analysis to identify factors associated with a risk for early mortality. Of the 2454 lung cancer patients, 2.0% (n = 50) died within 30 and 1.7% (n = 41) within 30 to 60 days of d...
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Amanda Tufman Sophie Schneiderbauer Julia Walter Blerina Resuli Diego Kauffmann-Guerrero Carlo M ümmler Pontus Mertsch Jeremias G ötschke Julia Kov ács Farkhad Manapov Christian Schneider Laura Sellmer Paola Arnold Volker Heinemann J ürgen Behr Daniel Source Type: research
Continuous Tunneled Infraclavicular Nerve Catheter for Palliative Management of Critical Limb Ischemia: A Case Report
We describe the successful use of a continuous local anesthetic infusion via an infraclavicular nerve catheter to control severe refractory ischemic upper limb pain in a patient with metastatic lung cancer for whom surgical and pharmacological intervention was unsuccessful. As her opioid requirements increased due to worsening ischemic pain, she subsequently developed opioid toxicity, hence prompting the palliative use of a tunneled infraclavicular nerve catheter under ultrasound guidance to minimize opioid requirements. Her opioid requirements tailed down subsequently with the successful insertion of the infraclavicular n...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Jia Lin Jacklyn Yek Nicodemus Oey Amit Jain Christopher Liu Nithia Angamuthu Source Type: research
Utility of psychotherapy assessed with Kessler scale in a population of cancer patients undergoing systemic oncological treatment: a mono-institutional experience
CONCLUSIONS: The use of the K10 test is helpful in monitoring the degree of psychological distress of patients facing the diagnosis of cancer and who are about to start oncological treatment. Psychotherapy is effective in reducing the distress of these patients just a few months after starting treatment.PMID:37699600 | DOI:10.21037/cco-23-54
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Pasquale Vitale Ida Bocchino Vincenzo De Falco Gelsomina Auletta Ilaria Di Giovanni Marco Bocchetti Annunziata Auriemma Roberto Conchiglia Raffaele Addeo Source Type: research
The predictive value of advanced lung cancer inflammation index for short-term outcomes and prognosis of colorectal cancer patients who underwent radical surgery
CONCLUSION: Lower ALI was associated with more postoperative complications, worse OS, and DFS for CRC patients who underwent radical surgery. Furthermore, ALI was an independent risk factor for overall complications, OS, and DFS. Surgeons should pay close attention to patients with low ALI before surgery and make clinical strategies cautiously.PMID:37700210 | DOI:10.1007/s10147-023-02410-1
Source: Clinical Colorectal Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Bin Zhang Zi-Wei Li Yue Tong Chao Yuan Xiao-Yu Liu Zheng-Qiang Wei Wei Zhang Dong Peng Source Type: research
Inhibitory role of bone marrow mesenchymal stem cells-derived exosome in non-small-cell lung cancer: microRNA-30b-5p, EZH2 and PI3K/AKT pathway
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17933. Online ahead of print.ABSTRACTExosomal microRNA (miRNA) exerts potential roles in non-small-cell lung cancer (NSCLC). The current study elucidated the role of miR-30b-5p shuttled by bone marrow mesenchymal stem cells (BMSCs)-derived exosomes in treating NSCLC. Bioinformatics analysis was performed with NSCLC-related miRNA microarray GSE169587 and mRNA data GSE74706 obtained for collection of the differentially expressed miRNAs and mRNAs. The relationship between miR-30b-5p and EZH2 was predicted and confirmed. Exosomes were isolated from BMSCs and identified. BMSCs-deri...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Tong Wu Qi Tian Ruiji Liu Ke Xu Shanshan Shi Xiudi Zhang Liming Gao Xiaobo Yin Shufeng Xu Ping Wang Source Type: research
Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17936. Online ahead of print.ABSTRACTThe most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were searched using the appropriate keywords through the databases PubMed, Science Direct and Scopus. The extracts and essential oils tested were all shown to effect lung cancer by several mechanisms inclu...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Arghavan Memarzia Saeideh Saadat Fereshteh Asgharzadeh Sepide Behrouz Gert Folkerts Mohammad Hossein Boskabady Source Type: research
Modern therapies of nonsmall cell lung cancer
J Appl Genet. 2023 Sep 12. doi: 10.1007/s13353-023-00786-4. Online ahead of print.ABSTRACTLung cancer (LC), particularly nonsmall cell lung cancer (NSCLC), is one of the most prevalent types of neoplasia worldwide, regardless of gender, with the highest mortality rates in oncology. Over the years, treatment for NSCLC has evolved from conventional surgery, chemotherapy, and radiotherapy to more tailored and minimally invasive approaches. The use of personalised therapies has increased the expected efficacy of treatment while simultaneously reducing the frequency of severe adverse effects (AEs). In this review, we discuss es...
Source: J Appl Genet - September 12, 2023 Category: Genetics & Stem Cells Authors: Andrzej Jachowski Miko łaj Marcinkowski Jakub Szyd łowski Oskar Grabarczyk Zuzanna Nogaj Łaz Marcin Andrzej P ławski Pawe ł Piotr Jagodziński Bartosz Kazimierz S łowikowski Source Type: research
Early mortality in German patients with lung cancer: risk factors associated with 30-and 60-day mortality
In this study, we aimed to assess risk factors for 30- and 60-day mortality in German lung cancer patients. In this retrospective cross-sectional analysis, we used data of lung cancer patients treated at LMU Hospital Munich between 2015 and 2019. We categorized patients into 30-day mortality, 60 day-mortality, and longer survival. We used Student's t-test and ANOVA to compare means and Chi2-test to compare frequencies. We used logistic regression analysis to identify factors associated with a risk for early mortality. Of the 2454 lung cancer patients, 2.0% (n = 50) died within 30 and 1.7% (n = 41) within 30 to 60 days of d...
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Amanda Tufman Sophie Schneiderbauer Julia Walter Blerina Resuli Diego Kauffmann-Guerrero Carlo M ümmler Pontus Mertsch Jeremias G ötschke Julia Kov ács Farkhad Manapov Christian Schneider Laura Sellmer Paola Arnold Volker Heinemann J ürgen Behr Daniel Source Type: research
Utility of psychotherapy assessed with Kessler scale in a population of cancer patients undergoing systemic oncological treatment: a mono-institutional experience
CONCLUSIONS: The use of the K10 test is helpful in monitoring the degree of psychological distress of patients facing the diagnosis of cancer and who are about to start oncological treatment. Psychotherapy is effective in reducing the distress of these patients just a few months after starting treatment.PMID:37699600 | DOI:10.21037/cco-23-54
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Pasquale Vitale Ida Bocchino Vincenzo De Falco Gelsomina Auletta Ilaria Di Giovanni Marco Bocchetti Annunziata Auriemma Roberto Conchiglia Raffaele Addeo Source Type: research
Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma
CONCLUSIONS: Seven MiAg-related genes were identified to be significantly associated with the prognosis of patients diagnosed with LUAD. Moreover, the identified MiAg DEGs might affect the immunotherapy strategy of patients with LUAD.PMID:37698683 | DOI:10.1007/s00432-023-05390-x
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Xiangzhi Meng Weijian Song Boxuan Zhou Mei Liang Yushun Gao Source Type: research
Inhibitory role of bone marrow mesenchymal stem cells-derived exosome in non-small-cell lung cancer: microRNA-30b-5p, EZH2 and PI3K/AKT pathway
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17933. Online ahead of print.ABSTRACTExosomal microRNA (miRNA) exerts potential roles in non-small-cell lung cancer (NSCLC). The current study elucidated the role of miR-30b-5p shuttled by bone marrow mesenchymal stem cells (BMSCs)-derived exosomes in treating NSCLC. Bioinformatics analysis was performed with NSCLC-related miRNA microarray GSE169587 and mRNA data GSE74706 obtained for collection of the differentially expressed miRNAs and mRNAs. The relationship between miR-30b-5p and EZH2 was predicted and confirmed. Exosomes were isolated from BMSCs and identified. BMSCs-deri...
Source: J Cell Mol Med - September 12, 2023 Category: Molecular Biology Authors: Tong Wu Qi Tian Ruiji Liu Ke Xu Shanshan Shi Xiudi Zhang Liming Gao Xiaobo Yin Shufeng Xu Ping Wang Source Type: research
Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17936. Online ahead of print.ABSTRACTThe most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were searched using the appropriate keywords through the databases PubMed, Science Direct and Scopus. The extracts and essential oils tested were all shown to effect lung cancer by several mechanisms inclu...
Source: J Cell Mol Med - September 12, 2023 Category: Molecular Biology Authors: Arghavan Memarzia Saeideh Saadat Fereshteh Asgharzadeh Sepide Behrouz Gert Folkerts Mohammad Hossein Boskabady Source Type: research
