Immune evasion of G-CSF and GM-CSF in lung cancer

Tuberc Respir Dis (Seoul). 2023 Sep 20. doi: 10.4046/trd.2023.0037. Online ahead of print.ABSTRACTTumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and function of G-CSF and GM-CSF, particularly their role in immune evasion in lung cancer. In addition, their effects on programmed death-ligand 1 expression and clinical implications are discussed.PMID:37726942 | DOI:10.4046/trd.2023.0037
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research