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Specialty: Drugs & Pharmacology
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Total 120827 results found since Jan 2013.
Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson's disease model
CONCLUSIONS: Progressive bilateral α-syn aggregation might lead to compensatory activity increase and alterations in emotionally regulated behavior, without affecting stress susceptibility. Understanding how α-syn aggregation and degeneration in specific brain structures contribute to depression and anxiety in PD patients requires further investigation.PMID:37725330 | DOI:10.1007/s43440-023-00530-z
Source: Pharmacological Reports - September 19, 2023 Category: Drugs & Pharmacology Authors: Anna Alwani Katarzyna Maziarz Gabriela Burda Monika Jankowska-Kie łtyka Adam Roman Gabriela Łyszczarz Safak Er Justyna Barut Olga Barczyk-Wo źnicka El żbieta Pyza Grzegorz Kreiner Irena Nalepa Piotr Chmielarz Source Type: research
Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling
In this study we investigated the effect of MYDGF to postinjury neointimal formation and the underlying mechanisms. Rat carotid arteries balloon-injured model was established. We found that plasma MYDGF content and the level of MYDGF in injured arteries were significantly decreased after balloon injury. Local application of exogenous MYDGF (50 μg/mL) around the injured vessel during balloon injury markedly ameliorated the development of neointimal formation evidenced by relieving the narrow endovascular diameter, improving hemodynamics, and reducing collagen deposition. In addition, local application of MYDGF inhibited VS...
Source: Acta Pharmacologica Sinica - September 19, 2023 Category: Drugs & Pharmacology Authors: Shuang Yang Hou-Wei Li Jia-Ying Tian Zheng-Kai Wang Yi Chen Ting-Ting Zhan Chun-Yue Ma Min Feng Shi-Feng Cao Yu Zhao Xue Li Jing Ren Qian Liu Lu-Ying Jin Zhi-Qi Wang Wen-Yu Jiang Yi-Xiu Zhao Yan Zhang Xue Liu Source Type: research
Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases
Biomed Pharmacother. 2023 Sep 17;167:115512. doi: 10.1016/j.biopha.2023.115512. Online ahead of print.ABSTRACTSesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugate...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 19, 2023 Category: Drugs & Pharmacology Authors: Navneet Singh Sukriti Vishwas Amandeep Kaur Harmanpreet Kaur Violina Kakoty Rubiya Khursheed M V N L Chaitanya Molakpogu Ravindra Babu Ankit Awasthi Leander Corrie Vancha Harish Palakurthi Yanadaiah Saurabh Gupta Amany A Sayed Amr El-Sayed Iftikhar Ali Os Source Type: research
Computational Studies and Synthesis of New Heterocyclics as CNS Agents
CONCLUSION: The designed scheme was executed in the departmental laboratory. The chemical structure of the compounds was confirmed on the basis of TLC, IR, and 1HNMR analyses. The docking study revealed a good docking score of the compounds. The Log P value of the compounds indicated their good penetration into CNS. The compounds were also screened for anxiolytic activity. Among them, compounds 4f, 4h, and P3 showed maximum activity as anti-anxiolytic agents.PMID:37723630 | DOI:10.2174/1570163820666230918100218
Source: Current Drug Discovery Technologies - September 19, 2023 Category: Drugs & Pharmacology Authors: Pooja Saini Sushil Kumar Source Type: research
Application of CMO (capacity, motivation, and opportunity) methodology in pharmaceutical care to optimize the pharmacotherapy in older people living with HIV. DISPIMDINAC project
CONCLUSIONS: The pharmaceutical intervention based onarmaceutical intervention based on the CMO methodology significantly decreased the prevalence of the PIMDINAC concept and increased the number of patients who achieved the objectives, optimising their pharmacotherapy.PMID:37724451 | DOI:10.37201/req/021.2023
Source: Revista Espanola de Quimioterapia - September 19, 2023 Category: Drugs & Pharmacology Authors: E S ánchez-Yáñez M J Huertas-Fern ández M A Robustillo-Cortes R Ramos-Guerrero S Fern ández-Espínola R Diaz-Acedo V Montero-Martin R Morillo-Verdugo Source Type: research
Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice
Clin Exp Pharmacol Physiol. 2023 Sep 19. doi: 10.1111/1440-1681.13825. Online ahead of print.ABSTRACTEpilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments. Current therapies fail to produce 100% outcomes because of the complexity of the disease, poor diagnosis, and upsurge to drug-resistant epilepsy. The study repurposed the drug 'noscapine' mainly known for its anti-tussive properties. For the management of epilepsy and its associated secondary complications. To confirm the effect of noscapine, adult mice were injected with pentylenetetrazole ...
Source: Clinical and Experimental Pharmacology and Physiology - September 19, 2023 Category: Drugs & Pharmacology Authors: Rishav Gupta Divya Soni Shubham Upadhayay Maanvi Dhureja Puneet Kumar Source Type: research
Application of CMO (capacity, motivation, and opportunity) methodology in pharmaceutical care to optimize the pharmacotherapy in older people living with HIV. DISPIMDINAC project
CONCLUSIONS: The pharmaceutical intervention based onarmaceutical intervention based on the CMO methodology significantly decreased the prevalence of the PIMDINAC concept and increased the number of patients who achieved the objectives, optimising their pharmacotherapy.PMID:37724451 | DOI:10.37201/req/021.2023
Source: Revista Espanola de Quimioterapia - September 19, 2023 Category: Drugs & Pharmacology Authors: E S ánchez-Yáñez M J Huertas-Fern ández M A Robustillo-Cortes R Ramos-Guerrero S Fern ández-Espínola R Diaz-Acedo V Montero-Martin R Morillo-Verdugo Source Type: research
Evaluating Prognostic Value of Dynamics of Circulating Lactate Dehydrogenase in Colorectal Cancer Using Modeling and Machine Learning
Clin Pharmacol Ther. 2023 Sep 19. doi: 10.1002/cpt.3052. Online ahead of print.ABSTRACTPre-treatment serum lactate dehydrogenase (LDH) levels have been associated with poor prognosis in several types of cancer, including metastatic colorectal cancer (mCRC). However, very few models link survival to longitudinal LDH measured repeatedly over time during treatment. We investigated the prognostic value of on-treatment LDH dynamics in mCRC. Using data from two large Phase III studies (2L and 3L+ mCRC settings, n = 824 and 210, respectively), we found that integrating longitudinal LDH data with baseline risk factors significantl...
Source: Clinical Pharmacology and Therapeutics - September 19, 2023 Category: Drugs & Pharmacology Authors: Haolun Ding Min Yuan Yaning Yang Manish Gupta Xu Steven Xu Source Type: research
Interleukin-6 Inhibition and Lipoprotein(a): An Association Requiring More Research
Curr Pharm Des. 2023 Sep 18. doi: 10.2174/1381612829666230918112907. Online ahead of print.NO ABSTRACTPMID:37723629 | DOI:10.2174/1381612829666230918112907
Source: Current Pharmaceutical Design - September 19, 2023 Category: Drugs & Pharmacology Authors: Aris P Agouridis Theodosios D Filippatos Source Type: research
Antimicrobial bacterial metabolites: properties, applications and loading in liposomes for site-specific delivery
Curr Pharm Des. 2023 Sep 18. doi: 10.2174/1381612829666230918111014. Online ahead of print.ABSTRACTThe high levels of antibiotic resistance registered worldwide have become a serious health problem, threatening the currently available treatments for a serious of infection diseases. With antibiotics becoming less and less effective, it is becoming increasingly difficult and, in some cases, impossible to treat patients with even common infectious diseases, such as pneumonia. The inability to meet the ever-increasing demand to control microbial infection requires both the search for new antimicrobials and improved site-specif...
Source: Current Pharmaceutical Design - September 19, 2023 Category: Drugs & Pharmacology Authors: Camilla A S Valen ça Ana A T Barbosa Silvio S Dolabella Patricia Severino Carla Matos Karolline Krambeck Eliana B Souto Sona Jain Source Type: research
Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson's disease model
CONCLUSIONS: Progressive bilateral α-syn aggregation might lead to compensatory activity increase and alterations in emotionally regulated behavior, without affecting stress susceptibility. Understanding how α-syn aggregation and degeneration in specific brain structures contribute to depression and anxiety in PD patients requires further investigation.PMID:37725330 | DOI:10.1007/s43440-023-00530-z
Source: Pharmacological Reports - September 19, 2023 Category: Drugs & Pharmacology Authors: Anna Alwani Katarzyna Maziarz Gabriela Burda Monika Jankowska-Kie łtyka Adam Roman Gabriela Łyszczarz Safak Er Justyna Barut Olga Barczyk-Wo źnicka El żbieta Pyza Grzegorz Kreiner Irena Nalepa Piotr Chmielarz Source Type: research
Co-administration of Thymoquinone and Propolis in Liposomal Formulations as a Potential Approach for Treatment of Acetic Acid-Induced Ulcerative Colitis: Physiological and Histopathological Analysis
This study is aimed at assessing the potential of liposomal formulations of TQ and Egyptian PP in combination therapy on improving their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects. Clinical, biochemical, and histological evaluations of colonic mucosal damage and inflammation were evaluated. The results exhibited a significant increase in tissue MDA, TNFα, and nitrite levels with activation of caspase-3 in the acetic acid-induced colitis group, which is predominantly downregulated in the treatment groups. The prepared formulations of TQ and PP rev...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Eman Alaaeldin Hesham Refaat Entesar Ali Saber Neven Makram Aziz Nehad M Reda Abdel-Maqsoud Mohammed Mustafa Abd El Aleem Maha Yehia Kamel Fatma M Mady Source Type: research
New Insights into the Applications of 3D-Printed Biomaterial in Wound Healing and Prosthesis
The objective of this review is to emphasize interpretations from the pre-executed studies and to assess the worth of employing 3D-bioP in wound healing as well as prosthetics in terms of patient compliance, clinical outcomes, and economic viability. Furthermore, the benefits of applying 3D-bioP in wound healing over traditional methods have been covered along with the biocompatible biomaterials employed as bioinks has been discussion. Additionally, the review expands about the clinical trials in 3D-bioP field, showing promise of biomedical applicability of this technique with growing advancement in recent years.PMID:37726...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Aayushi Pandey None Pragya Jovita Kanoujia Poonam Parashar Source Type: research
Design and Evaluation of Continentalic Acid Encapsulated Transfersomal Gel and Profiling of its Anti-arthritis Activity
AAPS PharmSciTech. 2023 Sep 19;24(7):192. doi: 10.1208/s12249-023-02648-y.ABSTRACTRheumatoid arthritis restricts the physical ability of patients and increases the disease burden; therefore, research has always been focused on evaluating better therapeutic options. The present research aimed to design Continentalic acid (CA)-loaded transfersomes (CA-TF) embedded in Carbopol gel containing permeation enhancer (PE) for the treatment of rheumatoid arthritis. CA-TF was developed via a modified thin film hydration method and incorporated into Carbopol 934 gel containing Eucalyptus oil (EO) as PE. The fabricated CA-TF showed par...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Muhammad Waseem Akram Danish Mazhar Iqra Afzal Ahmad Zeb Qurat Ul Ain Salman Khan Hussain Ali Source Type: research
Formulation and Development of Flurbiprofen Colon-Specific Eudragit Coated Matrix Tablets: Use of a Novel Crude Banana Peel Powder as a Time-Dependent Polymer
In conclusion, utilizing CBP as a natural, time-dependent polymer in conjunction with Eudragit® S 100 to develop the flurbiprofen tablets seems like a promising approach for delivering drugs specifically to the colon.PMID:37726501 | DOI:10.1208/s12249-023-02646-0
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Sateesh Kumar Vemula Bhaskar Daravath Sridhar Babu Gummadi Michael Repka Source Type: research
