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Specialty: Drugs & Pharmacology
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Total 120827 results found since Jan 2013.
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
Differential contribution of 5-HT < sub > 4 < /sub > , 5-HT < sub > 5 < /sub > , and 5-HT < sub > 6 < /sub > receptors to acute pruriceptive processing induced by chloroquine and histamine in mice
Biol Pharm Bull. 2023 Sep 16. doi: 10.1248/bpb.b23-00445. Online ahead of print.ABSTRACTThe involvement of serotonin (5-HT) and/or noradrenaline in acute pruriceptive processing in the central nervous system (CNS) has been reported using antidepressants, such as milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant; however, the roles of 5-HT receptor family in acute pruriceptive processing have not been fully elucidated in the CNS. In the present study, scratching behavior induced by chloroquine (CQ) was ameliorated by milnacipran or mirtaz...
Source: Biological and Pharmaceutical Bulletin - September 18, 2023 Category: Drugs & Pharmacology Authors: Yu Miyahara Hideki Funahashi Ayaka Haruta-Tsukamoto Yoichiro Kogoh Anna Kanemaru-Kawazoe Yoji Hirano Toshikazu Nishimori Yasushi Ishida Source Type: research
What is Polypharmacy in Patients with Chronic Kidney Disease? A Systematic Review
The objective of this review is to establish a unified definition of polypharmacy in the CKD population by examining the diverse definitions used in previously published studies.METHODS: A comprehensive search was conducted in relevant databases (PubMed, SCOPUS, Cochrane, and disease-specific databases) from 2000 to May 2022 to identify studies with polypharmacy threshold definitions in patients with CKD. Studies meeting the inclusion criteria were included in this review, and their methodologic quality was assessed.FINDINGS: Following the screening of the search results, duplicate records and studies that did not meet the...
Source: Clinical Therapeutics - September 18, 2023 Category: Drugs & Pharmacology Authors: Azhar Al-Khulaifi Malkan Khatib Elrazi Ali Mohamed Yousif Ali Mohammed Ibn-Mas'ud Danjuma Source Type: research
Effectiveness and Safety of Eliglustat Treatment in Gaucher Disease: Real-Life Unicentric Experience
In this study, we evaluated the effectiveness and safety of eliglustat in a cohort of 12 patients with GD followed up in our center, reporting a reduction in both chitotriosidase (394.3 vs 181.1 nmol/h/mL, P = 0.027) and glucosylsphingosine values (45.1 vs 18.9 ng/mL, P <0.001) after at least 12 months of therapy compared with baseline, regardless of patient demographic characteristics and GD characteristics.FINDINGS: There were no drug-related serious adverse effects and no drug-related cardiac events. Most adverse events were mild and transient, mainly dyspepsia and abdominal pain. Of interest, we reported an absence ...
Source: Clinical Therapeutics - September 18, 2023 Category: Drugs & Pharmacology Authors: Andrea Duminuco Manlio Fazio Stephanie Grasso Lara Gullo Carla Riccobene Valeria Calafiore Uros Markovic Francesco Di Raimondo Gaetano Giuffrida Source Type: research
Disulfiram-Like Reaction With Ginaton: A Case Report and Literature Review
This article details such a case from China. Healthcare providers should be proactive in educating patients about the potential adverse reactions related to using Ginaton and the importance of avoiding alcohol consumption while using it. Patients should also be advised to disclose their alcohol-consumption habits and seek medical advice before initiating treatment with any medication or supplement during treatment with Ginaton.PMID:37722955 | DOI:10.1016/j.clinthera.2023.08.013
Source: Clinical Therapeutics - September 18, 2023 Category: Drugs & Pharmacology Authors: Xiangji Dang Rui Wang Yan Liu Source Type: research
3D Printed Personalized Colon-targeted Tablets: A Novel Approach in Ulcerative Colitis Management
Curr Drug Deliv. 2023 Sep 15. doi: 10.2174/1567201821666230915150544. Online ahead of print.ABSTRACTUlcerative colitis (UC) and Crohn's disease (CD) are two types of idiopathic inflammatory bowel disease (IBD) that are increasing in frequency and incidence worldwide, particularly in highly industrialized countries. Conventional tablets struggle to effectively deliver anti-inflammatory drugs since the inflammation is localized in different areas of the colon in each patient. The goal of 3D printing technology in pharmaceutics is to create personalized drug delivery systems (DDS) that are tailored to each individual's specif...
Source: Current Drug Delivery - September 18, 2023 Category: Drugs & Pharmacology Authors: Yachana Mishra Vijay Mishra Alaa A A Aljabali Mohamed El-Tanani Gowhar A Naikoo Nitin Charbe Sai Raghuveer Chava Murtaza M Tambuwala Source Type: research
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-033123-123610. Online ahead of print.ABSTRACTRecent advances in chemical, molecular, and genetic approaches have provided us with an unprecedented capacity to identify drug-target interactions across the whole proteome and genome. Meanwhile, rapid developments of single-cell and spatial omics technologies are revolutionizing our understanding of the molecular architecture of biological systems. However, a significant gap remains in how we align our understanding of drug actions, traditionally based on molecular affinities, with the in vivo cellular and ...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Zhengyuan Pang Benjamin F Cravatt Li Ye Source Type: research
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051920-095416. Online ahead of print.ABSTRACTToday's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy, toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Expe...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Francis A L évi Alper Okyar Eva Hadadi Pasquale F Innominato Annabelle Ballesta Source Type: research
Effectiveness of Shuxuening injection in coronary heart disease: a systematic review and meta-analysis
Conclusion: SXNI can effectively improve angina symptoms, clinical efficacy, cardiac function, blood lipid indicators, and thrombosis factors of patients with CHD. However, more multi-center and large-sample studies are needed to confirm the conclusions due to the limitations of this study.Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=399606; Identifier: CRD42023433292.
Source: Frontiers in Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Source Type: research
Optimising antithrombotic therapy after ACS and PCI
Vascul Pharmacol. 2023 Sep 15:107228. doi: 10.1016/j.vph.2023.107228. Online ahead of print.ABSTRACTDual antiplatelet therapy, combining aspirin with a platelet P2Y12 receptor inhibitor, is the standard treatment for acute coronary syndrome patients undergoing percutaneous coronary intervention. The optimal type and duration of dual antiplatelet therapy depend on the patient's risk for ischemic and hemorrhagic complications. De-escalation strategies, such as switching to a less potent P2Y12 inhibitor, reducing the dose, or discontinuing one of the antiplatelet agents, may be suitable for high-risk bleeding patients with lo...
Source: Vascular Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Davide Capodanno Source Type: research
NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1
Biochem Pharmacol. 2023 Sep 15:115811. doi: 10.1016/j.bcp.2023.115811. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is considered one of the most aggressive solid tumours in humans. Despite its high mortality rate, effective targeted therapeutic strategies remain limited due to incomplete understanding of the underlying biological mechanisms. The NAP1L gene family has been implicated in the development and progression of various human tumours. However, the specific function and role of NAP1L5 (nucleosome assembly protein-like 5) in PDAC have not been fully elucidated. Therefore, in this study, we a...
Source: Biochemical Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Benli Xiao Yuzhen Ge Rui Zhao Yewei Zhang Yi Guo Shilong Zhang Bo Li Peng Qiu Zheng Chao Shi Zuo Source Type: research
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia
Biochem Pharmacol. 2023 Sep 15:115809. doi: 10.1016/j.bcp.2023.115809. Online ahead of print.ABSTRACTAlthough a great cure rate has been achieved for pediatric BCP-ALL, approximately 15% of patients do not respond to conventional chemotherapy and experience disease relapse. A major effort to improve the cure rates by treatment intensification would result in an undesirable increase in treatment-related toxicity and mortality, raising the need to identify novel therapeutic approaches. High-throughput (HTP) drug screening enables the profiling of patients' responses in vitro and allows the repurposing of compounds currently ...
Source: Biochemical Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Athanasios Oikonomou Luigia Valsecchi Manuel Quadri Titus Watrin Katerina Scharov Simona Procopio Jia-Wey Tu Melina Vogt Angela Maria Savino Daniela Silvestri Maria Grazia Valsecchi Andrea Biondi Arndt Borkhardt Sanil Bhatia Giovanni Cazzaniga Grazia Fazi Source Type: research
Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis
Biochem Pharmacol. 2023 Sep 15:115810. doi: 10.1016/j.bcp.2023.115810. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating diseases; it has a considerably poor prognosis and may become the second most lethal malignancy in the next 10 years. Chemotherapeutic resistance is common in PDAC; thus, it is necessary to exploit effective alternative drugs. In recent years, traditional folk medicines and their extracts have shown great potential in cancer treatment. The seed of Lagenaria siceraria (Molina) Standl. is a traditional medicine in Asia. Because of its analgesic effect...
Source: Biochemical Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Dongchao Xu Ajuan Liu Qiang Liu Hongchen Zhang Mengyao Tian Ying Bian Xiaofeng Zhang Meidan Ying Hongzhang Shen Source Type: research
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
Biomed Pharmacother. 2023 Sep 15;167:115518. doi: 10.1016/j.biopha.2023.115518. Online ahead of print.ABSTRACTHead and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an alternative administration route is needed to improve bioavailability and establish the optimal dosage of melatonin for cancer treatment. On the other hand, the use of patient-derived tumor models has transformed the field of drug research because they reflect the heterogenei...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Laura Martinez-Ruiz Javier Florido C ésar Rodriguez-Santana Alba L ópez-Rodríguez Ana Guerra-Librero Beatriz I Fern ández-Gil Patricia Garc ía-Tárraga Jos é Manuel Garcia-Verdugo Felix Oppel Holger Sudhoff David S ánchez-Porras Amadeo Ten-Steve Jo Source Type: research
Polyphyllin VII alleviates pulmonary hypertension by inducing miR-205-5p to target the β-catenin pathway
CONCLUSION: PP7 likely modulates β-catenin protein levels by promoting miR-205-5p expression, thereby alleviating PH, vascular remodeling and airway smooth muscle remodeling.PMID:37717533 | DOI:10.1016/j.biopha.2023.115516
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Fangyun Zhao Chunhong Pan Yue Zhang Jiao Yang Xiqian Xing Source Type: research
