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Total 120827 results found since Jan 2013.
TAT decorated siRNA polyplexes for inhalation delivery in anti-asthma therapy
Eur J Pharm Sci. 2023 Sep 16;190:106580. doi: 10.1016/j.ejps.2023.106580. Online ahead of print.ABSTRACTIn this work, a novel protonable copolymer was designed to deliver siRNA through the inhalation route, as an innovative formulation for the management of asthma. This polycation was synthesized by derivatization of α,β-poly(N-2-hydroxyethyl)D,L-aspartamide (PHEA) first with 1,2-Bis(3-aminopropylamino)ethane (bAPAE) and then with a proper amount of maleimide terminated poly(ethylene glycol) (PEG-MLB), with the aim to increase the superficial hydrophilicity of the system, allowing the diffusion trough the mucus layer. On...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Salvatore Emanuele Drago Marta Cabibbo Emanuela Fabiola Craparo Gennara Cavallaro Source Type: research
Recent engineering advances of EVs for compounds, nucleic acids, and TCM delivery
Eur J Pharm Sci. 2023 Sep 15;190:106584. doi: 10.1016/j.ejps.2023.106584. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are phospholipid bilayer nano-vesicles that were originally identified to deliver signals for intercellular communications. Based on the dynamic contents including proteins, nucleic acids and metabolites, EVs have been developed into diagnostic and therapeutic fields including cardiovascular diseases, neurological disorders and infectious diseases. A growing number of investigations revealed that EVs are also powerful carriers of loaded compounds and nucleic acids as enhanced treatments. Here...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Yunfeng Di Wei Wang Yong Wang Jingyu Wang Source Type: research
Attenuation of celecoxib cardiac toxicity using Poly( δ-decalactone) based nanoemulsion via oral route
Eur J Pharm Sci. 2023 Sep 15:106585. doi: 10.1016/j.ejps.2023.106585. Online ahead of print.ABSTRACTCelecoxib (CLX), a poorly soluble anti-inflammatory drug, requires administration in higher concentrations to produce therapeutic effects, oftentimes resulting in cardiac toxicity. Therefore, in this study, we employed a nanoemulsion technology to improve the solubility of CLX using poly(δ-decalactone) (PDL) polymer as an oil and mPEG-b-PDL as a surfactant. The nanoemulsion (NE) was successfully prepared via the nanoprecipitation method. In vitro characterization was performed for size, drug release, and stability. In vivo ...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Saurabh Maru Jyoti Verma Carl-Eric Wilen Jessica M Rosenholm Kuldeep K Bansal Source Type: research
Optimising antithrombotic therapy after ACS and PCI
Vascul Pharmacol. 2023 Sep 15:107228. doi: 10.1016/j.vph.2023.107228. Online ahead of print.ABSTRACTDual antiplatelet therapy, combining aspirin with a platelet P2Y12 receptor inhibitor, is the standard treatment for acute coronary syndrome patients undergoing percutaneous coronary intervention. The optimal type and duration of dual antiplatelet therapy depend on the patient's risk for ischemic and hemorrhagic complications. De-escalation strategies, such as switching to a less potent P2Y12 inhibitor, reducing the dose, or discontinuing one of the antiplatelet agents, may be suitable for high-risk bleeding patients with lo...
Source: Vascular Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Davide Capodanno Source Type: research
Transforming drug discovery with a high-throughput AI-powered platform: a 5-year experience with Patrimony
Drug Discov Today. 2023 Sep 15:103772. doi: 10.1016/j.drudis.2023.103772. Online ahead of print.ABSTRACTHigh-throughput computational platforms are being established to accelerate drug discovery. Servier launched the Patrimony platform to harness computational sciences and artificial intelligence (AI) to integrate massive multimodal data from internal and external sources. Patrimony has enabled researchers to prioritize therapeutic targets based on a deep understanding of the pathophysiology of immuno-inflammatory diseases. Herein, we share our experience regarding main challenges and critical success factors faced when in...
Source: Drug Discovery Today - September 17, 2023 Category: Drugs & Pharmacology Authors: Fran çois-Xavier Blaudin de Thé Claire Baudier Renan Andrade Pereira C éline Lefebvre Philippe Moingeon Patrimony Working Group Source Type: research
TAT Decorated siRNA Polyplexes For Inhalation Delivery in Anti-asthma Therapy
Eur J Pharm Sci. 2023 Sep 15:106580. doi: 10.1016/j.ejps.2023.106580. Online ahead of print.ABSTRACTIn this work, a novel protonable copolymer was designed to deliver siRNA through the inhalation route, as an innovative formulation for the management of asthma. This polycation was synthesized by derivatization of α,β-poly(N-2-hydroxyethyl)D,L-aspartamide (PHEA) first with 1,2-Bis(3-aminopropylamino)ethane (bAPAE) and then with a proper amount of maleimide terminated poly(ethylene glycol) (PEG-MLB), with the aim to increase the superficial hydrophilicity of the system, allowing the diffusion trough the mucus layer. Once t...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Salvatore Emanuele Drago Marta Cabibbo Emanuela Fabiola Craparo Gennara Cavallaro Source Type: research
Recent engineering advances of EVs for compounds, nucleic acids, and TCM delivery
Eur J Pharm Sci. 2023 Sep 15:106584. doi: 10.1016/j.ejps.2023.106584. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are phospholipid bilayer nano-vesicles that were originally identified to deliver signals for intercellular communications. Based on the dynamic contents including proteins, nucleic acids and metabolites, EVs have been developed into diagnostic and therapeutic fields including cardiovascular diseases, neurological disorders and infectious diseases. A growing number of investigations revealed that EVs are also powerful carriers of loaded compounds and nucleic acids as enhanced treatments. Herein, ...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Yunfeng Di Wei Wang Yong Wang Jingyu Wang Source Type: research
Attenuation of celecoxib cardiac toxicity using Poly( δ-decalactone) based nanoemulsion via oral route
Eur J Pharm Sci. 2023 Sep 15:106585. doi: 10.1016/j.ejps.2023.106585. Online ahead of print.ABSTRACTCelecoxib (CLX), a poorly soluble anti-inflammatory drug, requires administration in higher concentrations to produce therapeutic effects, oftentimes resulting in cardiac toxicity. Therefore, in this study, we employed a nanoemulsion technology to improve the solubility of CLX using poly(δ-decalactone) (PDL) polymer as an oil and mPEG-b-PDL as a surfactant. The nanoemulsion (NE) was successfully prepared via the nanoprecipitation method. In vitro characterization was performed for size, drug release, and stability. In vivo ...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Saurabh Maru Jyoti Verma Carl-Eric Wilen Jessica M Rosenholm Kuldeep K Bansal Source Type: research
Effervescent tablet-assisted deep eutectic solvent based on magnetic nanofluid for liquid phase microextraction of tyrosine kinase inhibitors in plasma samples by high-performance liquid chromatography
CONCLUSIONS: The developed method displayed high sensitivity, low consumption of solvent, low cost, simplicity, high recoveries, short extraction time, and good repeatability for determination of three anti-cancer drugs in human plasma samples.PMID:37717246 | DOI:10.1007/s43440-023-00524-x
Source: Pharmacological Reports - September 17, 2023 Category: Drugs & Pharmacology Authors: Khosrou Abdi Maryam Ezoddin Laleh Adlnasab Bahar Aziz Kabiri Mohammad Ali Karimi Somaye Behnamipour Houman Alimoradi Source Type: research
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNF α/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells
In this study, supernatant from tumor necrosis factorα (TNFα)-treated human mammary microvascular endothelial cell (HMMEC) promoted cell migration and pseudopod formation in TNBC cells, but these phenomena were disappeared in SC-co-treated HMMEC. TNFα enhanced the expression of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in both HMMEC and human umbilical vein endothelial cell (HUVEC). G-CSF promoted TNBC migration and invasion in vitro, while G-CSF neutralization antibody and SC both inhibited TNBC metastasis in Balb/c mice. SC had no inhibition on the G-CS...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Xiyu Mei Hao Ouyang Hong Zhang Wangya Jia Bin Lu Jingnan Zhang Lili Ji Source Type: research
The novel small molecule BH3 mimetic nobiletin synergizes with vorinostat to induce apoptosis and autophagy in small cell lung cancer
Biochem Pharmacol. 2023 Sep 14:115807. doi: 10.1016/j.bcp.2023.115807. Online ahead of print.ABSTRACTSmall cell lung cancer (SCLC) is a highly lethal subtype of lung cancer with few therapeutic options; therefore, the identification of new targets and drugs with potent combination therapy is desirable. We previously screened BH3 mimetics from a natural product library, and in this study, we validated nobiletin as a BH3 mimetic. Specifically, we observed its combination potential and mechanism with vorinostat in SCLC in vitro and in vivo. The results showed that combination treatment with nobiletin and vorinostat reduced th...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Yu-Qian Li Fang Fan Yuan-Ru Wang Lu-Yao Li Ya-Jun Cao Si-Meng Gu Shuai-Shuai Liu Yue Zhang Jie Wang Lu Tie Yan Pan Hui-Fang Li Xue-Jun Li Source Type: research
Interplay Between Estrogen, Kynurenine, and AHR Pathways: An Immunosuppressive Axis with Therapeutic Potential for Breast Cancer Treatment
Biochem Pharmacol. 2023 Sep 14:115804. doi: 10.1016/j.bcp.2023.115804. Online ahead of print.ABSTRACTBreast cancer is one of the most common malignancies among women worldwide. Estrogen exposure via endogenous and exogenous sources during a lifetime, together with environmental exposure to estrogenic compounds, represent the most significant risk factor for breast cancer development. As breast tumors establish, multiple pathways are deregulated. Among them is the aryl hydrocarbon receptor (AHR) signaling pathway. AHR, a ligand-activated transcription factor associated with the metabolism of polycyclic aromatic hydrocarbons...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Jorge Humberto Lim ón Pacheco Guillermo Elizondo Source Type: research
Emerging therapies in dyslipidaemias
Vascul Pharmacol. 2023 Sep 14:107229. doi: 10.1016/j.vph.2023.107229. Online ahead of print.ABSTRACTSeveral observations have shown that elevated levels of low-density lipoprotein cholesterol (LDL-C) are a cause of cardiovascular disease. Lowering LDL-C is a key strategy for reducing cardiovascular risk, with a continuous linear correlation between LDL-C reduction and cardiovascular benefit. Based on these observations, current guidelines have further lowered LDL-C goals and call for the use of more effective therapeutic interventions. In addition to statins, ezetimibe and the monoclonal antibodies targeting PCSK9, several...
Source: Vascular Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Alberico L Catapano Source Type: research
Translated article Medication reconciliation in pediatric hemato-oncologic patients: A multicenter study
CONCLUSIONS: In order to avoid or reduce errors in one of the critical safety points such as transitions of care, there are measures such as medication reconciliation. In the case of complex chronic pediatric patients, such as onco-hematological patients, the number of drugs as part of home treatment is the variable that has been associated with the presence of medication reconciliation errors on admission to hospital, and the omission of some medication was the main cause of these errors.PMID:37716875 | DOI:10.1016/j.farma.2023.07.012
Source: Farmacia Hospitalaria - September 16, 2023 Category: Drugs & Pharmacology Authors: Margarita Cuervas-Mons Vendrell Dolores Pilar Iturgoyen Fuentes Miquel Villaronga Flaque Maria Jos é Cabañas Poy Cecilia M Fern ández-Llamazares Concha Álvarez Del Vayo Carmen Gallego Fern ández Cristina Mart ínez Roca Yolanda Hern ández Gago Ana G Source Type: research
