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Total 120827 results found since Jan 2013.
Emerging therapies in dyslipidaemias
Vascul Pharmacol. 2023 Sep 14:107229. doi: 10.1016/j.vph.2023.107229. Online ahead of print.ABSTRACTSeveral observations have shown that elevated levels of low-density lipoprotein cholesterol (LDL-C) are a cause of cardiovascular disease. Lowering LDL-C is a key strategy for reducing cardiovascular risk, with a continuous linear correlation between LDL-C reduction and cardiovascular benefit. Based on these observations, current guidelines have further lowered LDL-C goals and call for the use of more effective therapeutic interventions. In addition to statins, ezetimibe and the monoclonal antibodies targeting PCSK9, several...
Source: Vascular Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Alberico L Catapano Source Type: research
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNF α/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells
In this study, supernatant from tumor necrosis factorα (TNFα)-treated human mammary microvascular endothelial cell (HMMEC) promoted cell migration and pseudopod formation in TNBC cells, but these phenomena were disappeared in SC-co-treated HMMEC. TNFα enhanced the expression of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in both HMMEC and human umbilical vein endothelial cell (HUVEC). G-CSF promoted TNBC migration and invasion in vitro, while G-CSF neutralization antibody and SC both inhibited TNBC metastasis in Balb/c mice. SC had no inhibition on the G-CS...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Xiyu Mei Hao Ouyang Hong Zhang Wangya Jia Bin Lu Jingnan Zhang Lili Ji Source Type: research
The novel small molecule BH3 mimetic nobiletin synergizes with vorinostat to induce apoptosis and autophagy in small cell lung cancer
Biochem Pharmacol. 2023 Sep 14:115807. doi: 10.1016/j.bcp.2023.115807. Online ahead of print.ABSTRACTSmall cell lung cancer (SCLC) is a highly lethal subtype of lung cancer with few therapeutic options; therefore, the identification of new targets and drugs with potent combination therapy is desirable. We previously screened BH3 mimetics from a natural product library, and in this study, we validated nobiletin as a BH3 mimetic. Specifically, we observed its combination potential and mechanism with vorinostat in SCLC in vitro and in vivo. The results showed that combination treatment with nobiletin and vorinostat reduced th...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Yu-Qian Li Fang Fan Yuan-Ru Wang Lu-Yao Li Ya-Jun Cao Si-Meng Gu Shuai-Shuai Liu Yue Zhang Jie Wang Lu Tie Yan Pan Hui-Fang Li Xue-Jun Li Source Type: research
Interplay Between Estrogen, Kynurenine, and AHR Pathways: An Immunosuppressive Axis with Therapeutic Potential for Breast Cancer Treatment
Biochem Pharmacol. 2023 Sep 14:115804. doi: 10.1016/j.bcp.2023.115804. Online ahead of print.ABSTRACTBreast cancer is one of the most common malignancies among women worldwide. Estrogen exposure via endogenous and exogenous sources during a lifetime, together with environmental exposure to estrogenic compounds, represent the most significant risk factor for breast cancer development. As breast tumors establish, multiple pathways are deregulated. Among them is the aryl hydrocarbon receptor (AHR) signaling pathway. AHR, a ligand-activated transcription factor associated with the metabolism of polycyclic aromatic hydrocarbons...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Jorge Humberto Lim ón Pacheco Guillermo Elizondo Source Type: research
Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor
In conclusion, TCs can protect against lung tissue fibrosis by releasing HGF, a process dependent on HK2.PMID:37715611 | DOI:10.1111/1440-1681.13823
Source: Clinical and Experimental Pharmacology and Physiology - September 16, 2023 Category: Drugs & Pharmacology Authors: Shaoyuan Zhang Linyi Sun Borong Chen Siyun Lin Jianmin Gu Lijie Tan Miao Lin Source Type: research
Clinician Response to Pharmacogenetic Clinical Decision Support Alerts
The objective of this study was to characterize clinician response following standardization of pharmacogenetic (PGx) clinical decision support alerts at University of Florida (UF) Health. A retrospective analysis of all PGx alerts that fired at a tertiary academic medical center from August 2020 through May 2022 was performed. Alert acceptance rate was calculated and compared across six gene-drug pairs, patient care setting, and clinician specialty. The disposition of the triggering medication was compared to the alert response and evaluated for congruence. There were a total of 818 alerts included for analysis of alert r...
Source: Clinical Pharmacology and Therapeutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Lauren K Lemke Emily J Cicali Roy Williams Khoa A Nguyen Larisa H Cavallari Kristin Wiisanen Source Type: research
Ethical Requirements for Human Challenge Studies: A Systematic Review of Reasons
Clin Pharmacol Ther. 2023 Sep 16. doi: 10.1002/cpt.3054. Online ahead of print.ABSTRACTHuman challenge studies (HCS) are controlled clinical trials in which participants are deliberately infected with a pathogen. Such trials are being developed for an increasing number of diseases. Partly as a result of the COVID-19 pandemic, there has been a recent ethical debate about the reasons for and against HCS in general, or rather, about the requirements that individual HCS must fulfill to be ethically acceptable. A systematic review was conducted to categorize and summarize such requirements and the reasons given for them. Ethics...
Source: Clinical Pharmacology and Therapeutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Matthias Katzer Sabine Salloch Christoph Schindler Marcel Mertz Source Type: research
Artificial Intelligence for Quantitative Modeling in Drug Discovery and Development: An Innovation & amp; Quality (IQ) Consortium Perspective on Use Cases and Best Practices
Clin Pharmacol Ther. 2023 Sep 16. doi: 10.1002/cpt.3053. Online ahead of print.ABSTRACTRecent breakthroughs in Artificial Intelligence (AI) and Machine Learning (ML) have ushered in a new era of possibilities across various scientific domains. One area where these advancements hold significant promise is model-informed drug discovery and development (MID3). To foster a wider adoption and acceptance of these advanced algorithms, the Innovation & Quality (IQ) Consortium initiated the AI/ML working group (WG) in 2021 with the aim of promoting their acceptance among the broader scientific community as well as by regulatory...
Source: Clinical Pharmacology and Therapeutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Nadia Terranova Didier Renard Mohamed H Shahin Sujatha Menon Youfang Cao Cornelis E C A Hop Sean Hayes Kumpal Madrasi Sven Stodtmann Thomas Tensfeldt Pavan Vaddady Nicholas Ellinwood James Lu Source Type: research
Targeting the opioid remifentanil: Protective effects and molecular mechanisms against organ ischemia-reperfusion injury
Biomed Pharmacother. 2023 Sep 14;167:115472. doi: 10.1016/j.biopha.2023.115472. Online ahead of print.ABSTRACTOpioids are widely used in clinical practice by activating opioid receptors (OPRs), but their clinical application is limited by a series of side effects. Researchers have been making tremendous efforts to promote the development and application of opioids. Fortunately, recent studies have identified the additional effects of opioids in addition to anesthesia and analgesia, particularly in terms of organ protection against ischemia-reperfusion (I/R) injury, with unique advantages. I/R injury in vital organs not onl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Shuyuan Yi Hong Cao Weilei Zheng Yin Wang Peifeng Li Shoushi Wang Zhixia Zhou Source Type: research
Contribution and therapeutic value of mitophagy in cerebral ischemia-reperfusion injury after cardiac arrest
Biomed Pharmacother. 2023 Sep 14;167:115492. doi: 10.1016/j.biopha.2023.115492. Online ahead of print.ABSTRACTCardiopulmonary resuscitation and related life support technologies have improved substantially in recent years; however, mortality and disability rates from cardiac arrest (CA) remain high and are closely associated with the high incidence of cerebral ischemia-reperfusion injury (CIRI), which is explained by a "double-hit" model (i.e., resulting from both ischemia and reperfusion). Mitochondria are important power plants in the cell and participate in various biochemical processes, such as cell differentiation and...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Zheng Li Jihong Xing Source Type: research
Preparation and evaluation of Cordyceps militaris polysaccharide- and sesame oil-loaded nanoemulsion for the treatment of candidal vaginitis in mice
CONCLUSION: C. militaris polysaccharide- and sesame oil-containing nanoemulsion is potential to be developed as intravaginal therapeutic strategy for C. albicans-induced vaginitis.PMID:37716120 | DOI:10.1016/j.biopha.2023.115506
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Hsueh-Yu Lu Wei-Chung Tsai Jia-Shan Liu Chung-Hsiung Huang Source Type: research
Two-month period of 500 mg lecithin-based delivery form of quercetin daily dietary supplementation counterbalances chronic fatigue symptoms: A double-blind placebo controlled clinical trial
CONCLUSION: The quercetin supplementation counterbalances CF symptoms.PMID:37716119 | DOI:10.1016/j.biopha.2023.115453
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Mariangela Rondanelli Antonella Riva Giovanna Petrangolini Clara Gasparri Simone Perna Source Type: research
Dioscorea nipponica Makino: A comprehensive review of its chemical composition and pharmacology on chronic kidney disease
Biomed Pharmacother. 2023 Sep 14;167:115508. doi: 10.1016/j.biopha.2023.115508. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a widespread ailment that significantly impacts global health. It is characterized by high prevalence, poor prognosis, and substantial healthcare costs, making it a major public health concern. The current clinical treatments for CKD are not entirely satisfactory, leading to a high demand for alternative therapeutic options. Chinese herbal medicine, with its long history, diverse varieties, and proven efficacy, offers a promising avenue for exploration. One such Chinese herbal medici...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Chenguang Wu Rui Zhang Jingjing Wang Yao Chen Wenhui Zhu Xiang Yi Yan Wang Lifan Wang Peng Liu Ping Li Source Type: research
Nuclear factor kappa B expression in non-small cell lung cancer
Biomed Pharmacother. 2023 Sep 14;167:115459. doi: 10.1016/j.biopha.2023.115459. Online ahead of print.ABSTRACTIn this mini-review, we discuss the role of NF-κB, a proinflammatory transcription factor, in the expression of genes involved in inflammation, proliferation, and apoptosis pathways, and link it with prognosis of various human cancers, particularly non-small cell lung cancer (NSCLC). We and others have shown that NF-κB activity can be impacted by post-translational S-glutathionylation through reversible formation of a mixed disulfide bond between its cysteine residues and glutathione (GSH). Clinical data analysis...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Leilei Zhang Claudia M Ludden Alexander J Cullen Kenneth D Tew Andr é Luís Branco de Barros Danyelle M Townsend Source Type: research
Translated article Medication reconciliation in pediatric hemato-oncologic patients: A multicenter study
CONCLUSIONS: In order to avoid or reduce errors in one of the critical safety points such as transitions of care, there are measures such as medication reconciliation. In the case of complex chronic pediatric patients, such as onco-hematological patients, the number of drugs as part of home treatment is the variable that has been associated with the presence of medication reconciliation errors on admission to hospital, and the omission of some medication was the main cause of these errors.PMID:37716875 | DOI:10.1016/j.farma.2023.07.012
Source: Farmacia Hospitalaria - September 16, 2023 Category: Drugs & Pharmacology Authors: Margarita Cuervas-Mons Vendrell Dolores Pilar Iturgoyen Fuentes Miquel Villaronga Flaque Maria Jos é Cabañas Poy Cecilia M Fern ández-Llamazares Concha Álvarez Del Vayo Carmen Gallego Fern ández Cristina Mart ínez Roca Yolanda Hern ández Gago Ana G Source Type: research
