Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson's disease model

CONCLUSIONS: Progressive bilateral α-syn aggregation might lead to compensatory activity increase and alterations in emotionally regulated behavior, without affecting stress susceptibility. Understanding how α-syn aggregation and degeneration in specific brain structures contribute to depression and anxiety in PD patients requires further investigation.PMID:37725330 | DOI:10.1007/s43440-023-00530-z

Source: Pharmacological Reports - September 19, 2023 Category: Drugs & Pharmacology Authors: Anna Alwani Katarzyna Maziarz Gabriela Burda Monika Jankowska-Kie łtyka Adam Roman Gabriela Łyszczarz Safak Er Justyna Barut Olga Barczyk-Wo źnicka El żbieta Pyza Grzegorz Kreiner Irena Nalepa Piotr Chmielarz Source Type: research