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Cancer: Colorectal Cancer
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Total 40091 results found since Jan 2013.
Receipt of Clinician Recommendation for Colorectal Cancer Screening Among Underscreened U.S. Adults
Ann Intern Med. 2023 Sep 12. doi: 10.7326/M23-1341. Online ahead of print.NO ABSTRACTPMID:37696035 | DOI:10.7326/M23-1341
Source: Annals of Internal Medicine - September 11, 2023 Category: Internal Medicine Authors: Jordan Baeker Bispo Priti Bandi Ahmedin Jemal Farhad Islami Source Type: research
Outcomes of Patients With Colorectal Liver Metastasis in the Developing World: Is Liver Transplantation for Unresectable Liver Metastasis, the Next Logical Step?
CONCLUSION: Liver transplant has the potential to benefit a small but significant portion of patients with unresectable liver metastasis.PMID:37693265 | PMC:PMC10483002 | DOI:10.1016/j.jceh.2023.03.009
Source: Clinical Colorectal Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Janesh M Mufaddal Kazi Shraddha Patkar Prudvi Raj S Abhiram Bhoyar Ashwin Desouza Avanish Saklani Mahesh Goel Source Type: research
Estimating Venous Thromboembolism Risk in Metastatic Colorectal Cancer Inpatients: Validation of Existing Risk Scores and Development of New Risk Scores
This study aimed to (1) evaluate the efficacy of 4 existing cancer-specific VTE models in predicting VTE incidence among hospitalized mCRC patients, and (2) examine the influence of incorporating mCRC molecular subtypes into these models. We conducted an evaluation of 4 cancer-specific VTE models, including Khorana, Vienna CATS, Protecht, and CONKO in a dataset involving 1392 mCRC patients. To evaluate the predictive performance, we utilized receiver operating characteristic (ROC) curves for both the original models and the modified models that incorporated microsatellite instability status or KRAS/NRAS/BRAF mutations. Mor...
Source: Clinical Colorectal Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Li Qin Zhikun Liang Jingwen Xie Xiaoyan Li Source Type: research
The LASRE trial: further support for laparoscopic total mesorectal excision?
Chin Clin Oncol. 2023 Aug 28:cco-23-52. doi: 10.21037/cco-23-52. Online ahead of print.NO ABSTRACTPMID:37691346 | DOI:10.21037/cco-23-52
Source: Clinical Colorectal Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Vignesh Narasimhan J Joshua Smith Source Type: research
Delays in cancer diagnosis: challenges and opportunities in Europe
CONCLUSIONS: For ensuring appropriate care, it is crucial to better understand how different factors, including physical and mental health morbidities, impact cancer diagnosis. The "NextGenerationEU" program and the "National Recovery and Resilience Plan" (PNNR in Italy) following the Covid-19 pandemic offer opportunities for reducing inequalities, improving cancer care and chronic disease management for ageing populations.PMID:37695178 | DOI:10.23750/abm.v94iS3.14513
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Cristina Renzi Stefano Odelli Federica Morani Sara Benitez Majano Carlo Signorelli Source Type: research
Laparoscopy-assisted vs. open surgery total mesorectal excision in low rectal cancer: commentary on the LASRE trial and review of current evidence
Chin Clin Oncol. 2023 Sep 8:cco-23-57. doi: 10.21037/cco-23-57. Online ahead of print.NO ABSTRACTPMID:37691345 | DOI:10.21037/cco-23-57
Source: Clinical Colorectal Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Jesus Badia-Closa Xavier Serra-Aracil Source Type: research
A biosensor based on graphene oxide nanocomposite for determination of carcinoembryonic antigen in colorectal cancer biomarker
Environ Res. 2023 Sep 9:117113. doi: 10.1016/j.envres.2023.117113. Online ahead of print.ABSTRACTColorectal cancer is still a major global health concern, and early detection and accurate biomarker analyses are critical to its successful management. This paper describes the design and testing of a new biosensor based on a graphene oxide (GO) nanocomposite for the exact measurement of carcinoembryonic antigen (CEA), a well-known biomarker for colorectal cancer. The current study attempted to create a highly sensitive immunosensor for sensitive measurement of CEA based on a polypropylene-imine-dendrimer (PPI) and GO nanocomp...
Source: Environmental Research - September 11, 2023 Category: Environmental Health Authors: Chenyu Tao Jalal Rouhi Source Type: research
Development of a xylose-inducible promoter and riboswitch combination system for manipulating gene expression in < em > Fusobacterium nucleatum < /em >
In this study, we engineered a leakage-free hybrid system for precise gene expression controls in Fusobacterium nucleatum by integrating the xylose-inducible expression system with the theophylline-responsive riboswitch. This innovative method enables concurrent control of target gene expression at both transcription and translation initiation levels. Using luciferase and the indole-producing enzyme tryptophanase (TnaA) as reporters, we demonstrated that the hybrid system displays virtually no observable signal in the absence of inducers. We employed this system to express FtsX, a protein related to fusobacterial cytokines...
Source: Applied and Environmental Microbiology - September 11, 2023 Category: Microbiology Authors: Bibek G C Peng Zhou Arindam Naha Jianhua Gu Chenggang Wu Source Type: research
Linc00239 Promotes Colorectal Cancer Development via MicroRNA-182-5p/Metadherin Axis
Biochem Genet. 2023 Sep 11. doi: 10.1007/s10528-023-10510-w. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are associated with colorectal cancer (CRC); however, CRC-related linc00239 functions have not been fully elucidated. Prognostic analysis of patients with CRC with linc00239 overexpression was performed using data from The Cancer Genome Atlas database. Cell Counting Kit-8 and Transwell were used to determine linc00239 functions for CRC cells. The lncRNA-miRNA-mRNA interaction network was used to screen target miRNAs and mRNAs regulated by linc00239. Quantitative real-time polymerase chain reaction and w...
Source: Biochemical Genetics - September 11, 2023 Category: Genetics & Stem Cells Authors: Jianian Guo Tingting Xie Shi Zhang Source Type: research
Synthesis and In Silico Studies of Quinazolinones as PARP-1 Inhibitors
CONCLUSION: All the synthesized compounds have a better docking score than niraparib (-9.05). Further, the synthesized compounds have a favorable ADME profile. Therefore, they may serve as important leads in discovering PARP-1 inhibitors.PMID:37691193 | DOI:10.2174/1386207326666230905153443
Source: Combinatorial Chemistry and High Throughput Screening - September 11, 2023 Category: Chemistry Authors: Maneesh Guleria Adarsh Kumar Ankit Kumar Singh Pradeep Kumar Source Type: research
Raloxifene, a SERM targets PD-L1: an in-silico study
CONCLUSIONS: PD-L1 is a potential target of the SERM raloxifene in-silico. Overall, this study is one step further towards immune checkpoint blockade using small-molecule inhibitors.PMID:37692949 | PMC:PMC10492081
Source: American Journal of Translational Research - September 11, 2023 Category: Research Authors: Chirag Chopra Tenzen Yodun Harpreet Singh Bhupender Singh Shashank K Singh Umesh Goutam Source Type: research
Small-molecule drugs of colorectal cancer: Current status and future directions
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 9:166880. doi: 10.1016/j.bbadis.2023.166880. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the third most commonly diagnosed cancer and the world's fourth most deadly cancer. CRC, as a genetic susceptible disease, faces significant challenges in optimizing prognosis through optimal drug treatment modalities. In recent decades, the development of innovative small-molecule drugs is expected to provide targeted interventions that accurately address the different molecular characteristics of CRC. Although the clinical application of single-target drugs is limited by the h...
Source: Biochimica et Biophysica Acta - September 11, 2023 Category: Biochemistry Authors: Yiren Yang Pengyu Liu Mingyang Zhou Linzhou Yin Miao Wang Ting Liu Xiaowen Jiang Huiyuan Gao Source Type: research
Growing Deficit in New Cancer Diagnoses 2 Years Into the COVID-19 Pandemic: A National Multicenter Study
CONCLUSION: Disruptions in new diagnoses of four common cancers (prostate, lung, bladder, and colorectal) seen early in the COVID-19 pandemic have persisted for 2 years. Although reductions improved from the early pandemic, new reductions during the Delta and Omicron waves demonstrate the continued impact of the COVID-19 pandemic on cancer care.PMID:37695458 | DOI:10.1245/s10434-023-14217-5
Source: Ann Oncol - September 11, 2023 Category: Cancer & Oncology Authors: Brian R Englum Shalini Sahoo Minerva Mayorga-Carlin Hilary Hayssen Tariq Siddiqui Douglas J Turner John D Sorkin Brajesh K Lal Source Type: research
Efficacy and safety of trastuzumab deruxtecan in patients with solid tumors: a systematic review and meta-analysis of 3 randomized controlled trials
Am J Cancer Res. 2023 Aug 15;13(8):3266-3274. eCollection 2023.ABSTRACTTrastuzumab deruxtecan (T-DXd, DS-8201) is a targeted antibody-drug conjugate that specifically targets human epidermal growth factor receptor 2 (HER2). In 2019, it was approved by the US Food and Drug Administration for the treatment of HER2-positive breast cancer. However, ongoing research is exploring its potential efficacy in other solid tumors, such as non-small-cell lung cancer and colorectal cancer, as well as in tumors with low HER2 levels. It is important to examine the safety and effectiveness of trastuzumab deruxtecan in these various types o...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Ze-Lin Cai Hui-Ting Yang Ting Huang Zhuo-Ran Yu Ning Ren Jing-Yang Su Xian-Lei Lin He-Ran Zhou Source Type: research
Raloxifene, a SERM targets PD-L1: an in-silico study
CONCLUSIONS: PD-L1 is a potential target of the SERM raloxifene in-silico. Overall, this study is one step further towards immune checkpoint blockade using small-molecule inhibitors.PMID:37692949 | PMC:PMC10492081
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Chirag Chopra Tenzen Yodun Harpreet Singh Bhupender Singh Shashank K Singh Umesh Goutam Source Type: research
