Synthesis and In Silico Studies of Quinazolinones as PARP-1 Inhibitors

CONCLUSION: All the synthesized compounds have a better docking score than niraparib (-9.05). Further, the synthesized compounds have a favorable ADME profile. Therefore, they may serve as important leads in discovering PARP-1 inhibitors.PMID:37691193 | DOI:10.2174/1386207326666230905153443

Source: Combinatorial Chemistry and High Throughput Screening - September 11, 2023 Category: Chemistry Authors: Maneesh Guleria Adarsh Kumar Ankit Kumar Singh Pradeep Kumar Source Type: research