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Cancer: Colorectal Cancer
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Total 40091 results found since Jan 2013.
The potential therapeutic applications of CRISPR/Cas9 in colorectal cancer
Curr Med Chem. 2023 Sep 15. doi: 10.2174/0929867331666230915103707. Online ahead of print.ABSTRACTThe application of the CRISPR-associated nuclease 9 (Cas9) system in tumor studies has led to the discovery of several new treatment strategies for colorectal cancer (CRC), including the recognition of novel target genes, the construction of animal mass models, and the identification of genes related to chemotherapy resistance. CRISPR/Cas9 can be applied to genome therapy for CRC, particularly regarding molecular-targeted medicines and suppressors. This review summarizes some aspects of using CRISPR/Cas9 in treating CRC. Furth...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Toktam Sahranavard Shima Mehrabadi Ghazaleh Pourali Mina Maftooh Hamed Akbarzade Seyed Mahdi Hassanian Majid Ghayour Mobarhan Gordon A Ferns Majid Khazaei Amir Avan Source Type: research
A real-world retrospective study to evaluate the reliability of cetuximab plus capecitabine versus capecitabine as maintenance therapy in patients with RAS and BRAF wild-type metastatic colorectal cancer
CONCLUSION: A maintenance therapy using cetuximab plus capecitabine improved survival in patients with metastatic CRC and is well tolerated by patients.PMID:37725905 | DOI:10.1159/000533528
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Jun Li Hang Zhang Xuli Guo Shaoting Dong Yi Li Weizhen Huang Xia Yuan Source Type: research
A 3 mm Port Reduces Postoperative Pain After Laparoscopic Colon Cancer Surgery: A Case-control Matched Study
CONCLUSIONS: The use of 3 mm trocars and instruments in laparoscopic colon cancer surgery can effectively reduce postoperative pain while maintaining perioperative safety.PMID:37725815 | DOI:10.1097/SLE.0000000000001218
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Jin Sun Choi Hyo Jun Kim Han-Ki Lim Min Jung Kim Rumi Shin Ji Won Park Seung-Bum Ryoo Kyu Joo Park Hyeree Park Aesun Shin Seung-Yong Jeong Source Type: research
Impact of adjuvant chemotherapy on long-term overall survival in patients with high-risk stage II colon cancer: a nationwide cohort study
CONCLUSION: 5-year overall survival was significantly higher in patients with high-risk stage II colon cancer treated with adjuvant chemotherapy compared with no chemotherapy. Adjuvant treatment was given to less than half of the patients who were eligible for it.PMID:37725517 | DOI:10.1080/0284186X.2023.2251086
Source: Acta Oncologica - September 19, 2023 Category: Cancer & Oncology Authors: Victoria Rosberg Mikkel Jessen Camilla Qvortrup Henry George Smith Peter-Martin Krarup Source Type: research
Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-associated Immunity in Lynch Syndrome
CONCLUSIONS: Together these data have important implications for cancer interception in LS, and document for the first-time biological effects of exercise in the immune system of a target organ in patients at-risk for cancer.PMID:37724990 | DOI:10.1158/1078-0432.CCR-23-0088
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Nan Deng Laura Reyes-Uribe Johannes F Fahrmann Whittney S Thoman Mark F Munsell Jennifer B Dennison Eunice Murage Ranran Wu Ernest T Hawk Selvi Thirumurthi Patrick M Lynch Christina M Dieli-Conwright Alexander J Lazar Sonali Jindal Khoi Chu Manoj Chelvana Source Type: research
Comparative Analysis of First-Line FOLFOX Treatment With and Without Anti-VEGF Therapy in Metastatic Colorectal Carcinoma: A Real-World Data Study
CONCLUSION: Our real-world data analysis suggests that the addition of anti-VEGF to FOLFOX offers limited and short-lived benefits in the context of mCRC and may provide differential survival benefit based on tumor sidedness.PMID:37724508 | DOI:10.1177/10732748231202470
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Ronen Brenner Shlomit Amar-Farkash Avital Klein-Brill Keren Rosenberg-Katz Dvir Aran Source Type: research
Vegetarian diets and the risk of gastrointestinal cancers: a meta-analysis of observational studies
CONCLUSION: Adhering to vegetarian diets reduces the risk of gastrointestinal tumorigenesis. More data from well-conducted cohort and other studies are needed.PMID:37724454 | DOI:10.1097/MEG.0000000000002643
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Tongtong Bai Juanjuan Peng Xinqi Zhu Chengyu Wu Source Type: research
Association of lncRNA MEG3 Rs7158663 Polymorphism and Serum Expression with Colorectal Cancer in Egyptian Patients
CONCLUSIONS: MEG3 low expression and MEG3 rs7158663 (AA) were associated with CRC risk in Egyptian patients and may serve as a diagnostic and prognostic marker for CRC patients.PMID:37724147 | PMC:PMC10505460 | DOI:10.52547/rbmb.12.1.102
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Mona Elhelaly Elsherbeny Alyaa Ramadan Elsergany Olfat Gamil Shaker Source Type: research
Anti-Cancer Effect of < em > Dorema Ammoniacum Gum < /em > by Targeting Metabolic Reprogramming by Regulating < em > APC, P53, KRAS < /em > Gene Expression in HT-29 Human Colon Cancer Cells
CONCLUSION: This study's results indicate that the dichloromethane solvent of Dorema ammoniacum gum exhibits its antitumor properties by altering the expression of genes involved in HT-29 cells and the consequent change in downstream metabolic reprogramming.PMID:37724146 | PMC:PMC10505474 | DOI:10.52547/rbmb.12.1.127
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Elham Ghodousi-Dehnavi Mohammad Arjmand Ziba Akbari Mansour Aminzadeh Reza Haji Hosseini Source Type: research
Pre-operative Neo-adjuvant Chemotherapy Related miRNAs as Key Regulators and Therapeutic Targets in Colorectal Cancer
CONCLUSION: In patients with colorectal cancer, miRNA expression in the tumoral regions before and after neoadjuvant therapy has represented a variable pattern. It has been shown that miRNA studies can be used to predict the clinical course and response to treatment with differences in expression levels. It has been concluded that specific miRNAs may be candidate biomarkers for colorectal cancer.PMID:37723961 | DOI:10.2174/1874609816666230816152744
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Orcun Yalav Ozge Sonmezler Kivilcim Eren Erdogan Ahmet Rencuzogullari Figen Doran Atil Bisgin Ibrahim Boga Source Type: research
Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development
Autophagy. 2023 Sep 18. doi: 10.1080/15548627.2023.2259214. Online ahead of print.ABSTRACTColitis-associated colon cancer (CAC) is a distinct form of colorectal cancer that emerges from prolonged colitis in individuals with inflammatory bowel disease (IBD). Chronic inflammation is considered as the most critical contributor to the development and progression of CAC, with the degree and persistence of the inflammatory response being the primary drivers of CAC progression in individuals with IBD. Macroautophagy/autophagy, which is a cellular process that aids in preserving the intestinal mucosal barrier and regulating intest...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Xuanhong Jin Liangkun You Jincheng Qiao Weidong Han Hongming Pan Source Type: research
Construction of a novel cancer-associated fibroblast-related signature to predict clinical outcome and immune response in colon adenocarcinoma
Aging (Albany NY). 2023 Sep 16;15. doi: 10.18632/aging.205032. Online ahead of print.ABSTRACTThe interaction between the tumour and the surrounding microenvironment determines the malignant biological behaviour of the tumour. Cancer-associated fibroblasts (CAFs) coordinate crosstalk between cancer cells in the tumour immune microenvironment (TIME) and are extensively involved in tumour malignant behaviours, such as immune evasion, invasion and drug resistance. Here, we performed differential and prognostic analyses of genes associated with CAFs and constructed CAF-related signatures (CAFRs) to predict clinical outcomes in ...
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Lei Zheng Jiale Zhang Yingquan Ye Zhangpeng Shi Yi Huang Mengmeng Zhang Zhongxuan Gui Ping Li Huanlong Qin Weijie Sun Mei Zhang Source Type: research
Anti-Cancer Effect of < em > Dorema Ammoniacum Gum < /em > by Targeting Metabolic Reprogramming by Regulating < em > APC, P53, KRAS < /em > Gene Expression in HT-29 Human Colon Cancer Cells
CONCLUSION: This study's results indicate that the dichloromethane solvent of Dorema ammoniacum gum exhibits its antitumor properties by altering the expression of genes involved in HT-29 cells and the consequent change in downstream metabolic reprogramming.PMID:37724146 | PMC:PMC10505474 | DOI:10.52547/rbmb.12.1.127
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Elham Ghodousi-Dehnavi Mohammad Arjmand Ziba Akbari Mansour Aminzadeh Reza Haji Hosseini Source Type: research
Evaluating Prognostic Value of Dynamics of Circulating Lactate Dehydrogenase in Colorectal Cancer Using Modeling and Machine Learning
Clin Pharmacol Ther. 2023 Sep 19. doi: 10.1002/cpt.3052. Online ahead of print.ABSTRACTPre-treatment serum lactate dehydrogenase (LDH) levels have been associated with poor prognosis in several types of cancer, including metastatic colorectal cancer (mCRC). However, very few models link survival to longitudinal LDH measured repeatedly over time during treatment. We investigated the prognostic value of on-treatment LDH dynamics in mCRC. Using data from two large Phase III studies (2L and 3L+ mCRC settings, n = 824 and 210, respectively), we found that integrating longitudinal LDH data with baseline risk factors significantl...
Source: Clinical Pharmacology and Therapeutics - September 19, 2023 Category: Drugs & Pharmacology Authors: Haolun Ding Min Yuan Yaning Yang Manish Gupta Xu Steven Xu Source Type: research
The lncRNA MIR99AHG directs alternative splicing of < em > SMARCA1 < /em > by PTBP1 to enable invadopodia formation in colorectal cancer cells
Sci Signal. 2023 Sep 19;16(803):eadh4210. doi: 10.1126/scisignal.adh4210. Epub 2023 Sep 19.ABSTRACTAlternative splicing regulates gene expression and functional diversity and is often dysregulated in human cancers. Here, we discovered that the long noncoding RNA (lncRNA) MIR99AHG regulated alternative splicing to alter the activity of a chromatin remodeler and promote metastatic behaviors in colorectal cancer (CRC). MIR99AHG was abundant in invasive CRC cells and metastatic tumors from patients and promoted motility and invasion in cultured CRC cells. MIR99AHG bound to and stabilized the RNA splicing factor PTBP1, and this...
Source: Science Signaling - September 19, 2023 Category: Biomedical Science Authors: Danxiu Li Xin Wang Hui Miao Hao Liu Maogui Pang Hao Guo Minghui Ge Sarah E Glass Stephan Emmrich Songtao Ji Yun Zhou Xiaoni Ye Huajie Mao Jing Wang Qi Liu Taewan Kim Jan-Henning Klusmann Cunxi Li Zhenxiong Liu Haifeng Jin Yongzhan Nie Kaichun Wu Daiming F Source Type: research
