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Specialty: Cytology
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Total 80202 results found since Jan 2013.
Impact of tidal volume strategy at birth on initiating lung injury in preterm lambs
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 20. doi: 10.1152/ajplung.00159.2023. Online ahead of print.ABSTRACTTidal ventilation is essential in supporting the transition to air-breathing at birth, but excessive tidal volume (VT) is an important factor in preterm lung injury. Few studies have assessed the impact of specific VT levels on injury development. Here we used a lamb model of preterm birth to investigate the role of different levels of VT during positive pressure ventilation (PPV) in promoting aeration and initiating early lung injury pathways. VT was delivered as; (i) 7ml/kg throughout (VTstatic), (ii) begun at ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 20, 2023 Category: Cytology Authors: Prue M Pereira-Fantini Kelly R Kenna Monique Fatmous Arun Sett Ellen Douglas Sophia Dahm Magdy Sourial Haoyun Fang David W Greening David G Tingay Source Type: research
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
Critical functions of extracellular matrix in brain metastasis seeding
Cell Mol Life Sci. 2023 Sep 20;80(10):297. doi: 10.1007/s00018-023-04944-z.ABSTRACTHuman brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development. In this review, we provide a comprehensive outlook on how ECM proteins promote brain metastasis seeding. In particular, we discuss (1) disruption of the blood-brain barrier in brain metastas...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Arseniy E Yuzhalin Dihua Yu Source Type: research
Human CD34 < sup > + < /sup > -derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8 < sup > + < /sup > T cell and NK cell responses in vitro and in vivo
In this study, we aimed to dissect the phenotypic identity of these non-DCs and their potential immune modulatory functions on the potency of cDCs and pDCs in stimulating tumor-reactive CD8+ T and NK cell responses, in order to obtain rationale for clinical translation of our DC-complete vaccine. The non-DC compartment was heterogeneous and comprised of myeloid progenitors and (immature) granulocyte- and monocyte-like cells. Importantly, non-DCs potentiated toll-like receptor-induced DC maturation, as reflected by increased expression of co-stimulatory molecules and enhanced cDC-derived IL-12 and pDC-derived IFN-α product...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Jesper van Eck van der Sluijs Diede van Ens Jolanda Brummelman Daan Heister Aastha Sareen Lisa Truijen Dorette S van Ingen Schenau Mirjam H M Heemskerk Marieke Griffioen Michel G D Kester Nicolaas P M Schaap Joop H Jansen Anniek B van der Waart Harry Dols Source Type: research
Correction: Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
Cell Mol Life Sci. 2023 Sep 20;80(10):296. doi: 10.1007/s00018-023-04942-1.NO ABSTRACTPMID:37728633 | PMC:PMC10511356 | DOI:10.1007/s00018-023-04942-1
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Sunil Yeruva Konstanze Stangner Anna Jungwirth Matthias Hiermaier Maria Shoykhet Daniela Kugelmann Michael Hertl Shohei Egami Norito Ishii Hiroshi Koga Takashi Hashimoto Michael Weis Britt-Maria Beckmann Ruth Biller Dominik Sch üttler Stefan K ääb Jens Source Type: research
ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research
Twenty years of research in melanoma therapy-From "nothing works" to cures: A personal account
Pigment Cell Melanoma Res. 2023 Sep 19. doi: 10.1111/pcmr.13133. Online ahead of print.NO ABSTRACTPMID:37726985 | DOI:10.1111/pcmr.13133
Source: Pigment Cell and Melanoma Research - September 20, 2023 Category: Cytology Authors: Meenhard Herlyn Jessie Villanueva Source Type: research
Implementing standardized diversity, equity, and inclusion approaches within scientific communities
Trends Cell Biol. 2023 Sep 18:S0962-8924(23)00170-8. doi: 10.1016/j.tcb.2023.08.006. Online ahead of print.ABSTRACTWithin the global scientific community, there are disparate approaches to diversity, equity, and inclusion (DEI) practices, leading to inequalities that hinder progress. Here, we frame this problem through historical perspectives in the global north and propose a DEI framework adaptable by institutions regardless of location, improving the academic environment for researchers globally.PMID:37730511 | DOI:10.1016/j.tcb.2023.08.006
Source: Trends in Cell Biology - September 20, 2023 Category: Cytology Authors: Aidira D Y Macias Gonzalez Sarah McCallum Jacqueline A De Lora Source Type: research
AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway
In this study, we found that activation of AMPK by AICAR and metformin inhibits foam cell formation via suppression of mTOR in macrophages. Specifically, activation of AMPK indirectly reduced the phosphorylation level of mTOR at Ser2448 and promoted the expression of cholesterol efflux transporters and cholesterol efflux. These inhibitory effects on foam cell formation were counteracted by mTOR activators. Metformin, a more nonspecific AMPK activator than AICAR, appears to inhibit foam cell formation via anti-inflammatory effects in addition to suppression of the mTOR pathway. The results of this study suggest that the dev...
Source: Experimental Cell Research - September 20, 2023 Category: Cytology Authors: Reina Owaki Hiromasa Aoki Kohki Toriuchi Yasumichi Inoue Hidetoshi Hayashi Satoru Takeshita Hiroki Kakita Yasumasa Yamada Mineyoshi Aoyama Source Type: research
Molecular architecture of TMEM63 mechanosensitive ion channels
Cell Calcium. 2023 Sep 11;115:102798. doi: 10.1016/j.ceca.2023.102798. Online ahead of print.NO ABSTRACTPMID:37729772 | DOI:10.1016/j.ceca.2023.102798
Source: Cell Calcium - September 20, 2023 Category: Cytology Authors: Jed T Syrenne Parshuram J Sonawane Swetha E Murthy Source Type: research
Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling
This study provides a mechanistic understanding of the relationship between the Hippo pathway, polarity, and actomyosin cytoskeleton, and it offers novel insights into how fundamental features of epithelial tissue architecture can serve as inputs into signaling cascades that control tissue growth, patterning, and morphogenesis.PMID:37729921 | DOI:10.1016/j.devcel.2023.08.029
Source: Developmental Cell - September 20, 2023 Category: Cytology Authors: Sherzod A Tokamov Nicki Nouri Ashley Rich Stephan Buiter Michael Glotzer Richard G Fehon Source Type: research
Cinnamaldehyde inhibits cytokine storms induced by the ORF3a protein of SARS-CoV-2 via ROS-elimination in activated T cells
Phytother Res. 2023 Sep 19. doi: 10.1002/ptr.8016. Online ahead of print.ABSTRACTCytokine storms are the cause of complications in patients with severe COVID-19, and it becomes the target of therapy. Several natural compounds were selected to screen the inhibitory effect on T-cell proliferation by Fluorescence-Activated Cell Sorting (FACS) and cytokine production by enzyme-linked immunosorbent assay (ELISA). Open reading frame 3a (ORF3a) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulates the specific T-cell activation model in vivo and in vitro. The coculture system included the macrophage cell line...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Jing Ma Xu Chen Rui Xue Fei Wang Jun Dong Ning Tao Zhihai Qin Source Type: research
Correction
Autophagy. 2023 Sep 19:1. doi: 10.1080/15548627.2023.2260140. Online ahead of print.NO ABSTRACTPMID:37725507 | DOI:10.1080/15548627.2023.2260140
Source: Autophagy - September 19, 2023 Category: Cytology Source Type: research
Establishing an Efficient Electroporation-Based Method to Manipulate Target Gene Expression in the Axolotl Brain
Cell Transplant. 2023 Jan-Dec;32:9636897231200059. doi: 10.1177/09636897231200059.ABSTRACTThe tetrapod salamander species axolotl (Ambystoma mexicanum) is capable of regenerating injured brain. For better understanding the mechanisms of brain regeneration, it is very necessary to establish a rapid and efficient gain-of-function and loss-of-function approaches to study gene function in the axolotl brain. Here, we establish and optimize an electroporation-based method to overexpress or knockout/knockdown target gene in ependymal glial cells (EGCs) in the axolotl telencephalon. By orientating the electrodes, we were able to a...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Sulei Fu Cheng Peng Yan-Yun Zeng Yuanhui Qiu Yanmei Liu Ji-Feng Fei Source Type: research
Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha ís Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
