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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Anti-Infectious Human Vaccination in Historical Perspective.
Authors: D'Amelio E, Salemi S, D'Amelio R
Abstract
A brief history of vaccination is presented since the Jenner's observation, through the first golden age of vaccinology (from Pasteur's era to 1938), the second golden age (from 1940 to 1970), until the current period. In the first golden age, live, such as Bacille Calmette Guérin (BCG), and yellow fever, inactivated, such as typhoid, cholera, plague, and influenza, and subunit vaccines, such as tetanus and diphtheria toxoids, have been developed. In the second golden age, the cell culture technology enabled polio, measles, mumps, and rubella vaccines be developed...
Source: International Reviews of Immunology - January 30, 2018 Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Fresh search for a vaccine against malaria parasite Plasmodium vivax
Hundreds of millions of people each year are infected with Plasmodium vivax, the most widespread form of malaria worldwide. An EU-funded project is tackling the mosquito-borne parasite, leading cutting-edge research efforts to accelerate the development of effective vaccines.
Source: EUROPA - Research Information Centre - April 25, 2018 Category: Research Source Type: news
Where Is the Boundary to Augment Life?
Cloning, CRISPR and gene editing, synthetic life forms, and longevity. The latest scientific discoveries are able to offset the natural order of human existence and meddle with sacred questions of life and death. Even so, does gaining insight into the secrets of being mean it should also be put into practice? Are we aware of the consequences? Where are the boundaries to augment life?
Life, death and the coin for Charon the Ferryman
In Japanese folklore, the Shinigami, gods or spirits of death came to the persons who were destined to die and invited them over the threshold of life and death. In ancient Egypt, Anubis, having...
Source: The Medical Futurist - July 28, 2018 Category: Information Technology Authors: nora Tags: Bioethics Cyborgization artificial intelligence augmentation bioethical cloning CRISPR death future gene editing Health Healthcare life longevity research synthetic life Source Type: blogs
Composition and mode of action of adjuvants in licensed viral vaccines.
In this report, adjuvants that are components of vaccines licensed in the EU will be presented and their mode of action will be discussed.Aluminum salts have been used for almost a century as vaccine adjuvants. In recent years numerous novel immune-stimulating substances have been developed and integrated into licensed human vaccines. These novel adjuvants are not only intended to generally increase the vaccine-induced antibody titers, but are also aimed at modulating and triggering a specific immune response. The search for innovative adjuvants was considerably stimulated during development of pandemic influenza vaccine...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - March 3, 2019 Category: International Medicine & Public Health Authors: Wagner R, Hildt E Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: a review
ConclusionThe most advanced phase III clinical applications led to the development of two vaccines containing QS-21 as part of AS, the Herpes Zoster vaccine (HZ/su) (ShingrixTM) which received a license in 2017 from the FDA and a marketing authorization in EU in 2018 and the RTS,S/AS01 vaccine (MosquirixTM) against malaria which was approved by the EMA in 2015 for further implementation in Sub Saharan countries for routine use.Graphical abstract
Source: Phytomedicine - April 1, 2019 Category: Drugs & Pharmacology Source Type: research
An Animal Model of Acute and Chronic Chagas Disease With the Reticulotropic Y Strain of Trypanosoma cruzi That Depicts the Multifunctionality and Dysfunctionality of T Cells
In conclusion, during acute T. cruzi infection with the reticulotropic Y strain, immune activation leads to the generation of antigen-specific multifunctional CD4+ Th1 and CD8+ Tc1 cells and their regulation by inhibitory receptor co-expression. In contrast, during chronic T. cruzi infection, the chronicity of the infection induces a moderate inflammatory infiltrate in colon and liver tissues accompanied with poor T cell effector function that is possibly related to the co-expression of inhibitory receptors on T cells, but this phenomenon does not occur in cytotoxic CD8+ T cells. Taken together, these data supp...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research
Perspectives Vaccines and global health: In search of a sustainable model for vaccine development and delivery
Most vaccines for diseases in low- and middle-income countries fail to be developed because of weak or absent market incentives. Conquering diseases such as tuberculosis, HIV, malaria, and Ebola, as well as illnesses caused by multidrug-resistant pathogens, requires considerable investment and a new sustainable model of vaccine development involving close collaborations between public and private sectors.
Source: Science Translational Medicine - June 18, 2019 Category: Biomedical Science Authors: Rappuoli, R., Black, S., Bloom, D. E. Tags: Perspectives Source Type: research
Digital Health And The Ebola Epidemic: How Not To Let It Go Viral
More than 1,500 deaths
and 2,500 people sickened – that’s the recent account of the ebola outbreak in
the Democratic Republic of Congo (DRC) raging in the country since last August,
and recently declared a public health emergency of international concern. Experts
say efforts to contain the virus are hindered by biological, public health,
political, and cultural issues, but we looked around what digital health
technologies could do to mitigate the spread and the devastation of the
infectious disease.
The
Spaghetti-like virus…
The
lethal Ebola virus first appeared in 1976 around a river in Congo – it was
named ...
Source: The Medical Futurist - August 1, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine Africa AI artificial intelligence Congo digital digital health digital maps disease disease outbreak ebola epidemic Innovation technology Source Type: blogs
Fight Aging! Newsletter, August 12th 2019
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined.
Mean nonfasting cholesterol concentration was 72â...
Source: Fight Aging! - August 11, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Antibody-Dependent, Gamma Interferon-Independent Sterilizing Immunity Induced by a Subunit Malaria Vaccine Microbial Immunity and Vaccines
In this study, we report that immunization with recombinant CSP from Plasmodium yoelii (rPyCSP), when delivered in Montanide ISA 51, induced sterilizing immunity against sporozoite challenge in C57BL/6 and BALB/c strains of mice. This immunity was antibody dependent, as evidenced by the complete loss of immunity in B-cell-knockout (KO) mice and by the ability of immune sera to neutralize sporozoite infectivity in mice. Th2-type isotype IgG1 antibody levels were associated with protective immunity. The fact that immunized gamma interferon (IFN-)-KO mice and wild-type (WT) mice have similar levels of protective immunity and ...
Source: Infection and Immunity - September 18, 2019 Category: Infectious Diseases Authors: Chawla, B., Mahajan, B., Oakley, M., Majam, V. F., Belmonte, A., Sedegah, M., Shimp, R. L., Kaslow, D. C., Kumar, S. Tags: Microbial Immunity and Vaccines Source Type: research
Overcoming challenges in the diagnosis and treatment of parasitic infectious diseases in migrants.
Authors: Norman FF, Comeche B, Chamorro S, López-Vélez R
Abstract
Introduction: Recent increases in population movements have created novel health challenges in many areas of the World, and health policies have been adapted accordingly in several countries. However, screening guidelines for infectious diseases are not standardized and generally do not include comprehensive screening for parasitic infections.Areas covered: Malaria, Chagas disease, leishmaniasis, amebiasis, filariases, strongyloidiasis and schistosomiasis are reviewed, focusing on the challenges posed for their diagnosis and management in vulnerabl...
Source: Expert Review of Anti-Infective Therapy - January 10, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free."
Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease
https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/
I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is t...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model.
Authors: Lambraño J, Curtidor H, Avendaño C, DÃaz-Arévalo D, Roa L, Vanegas M, Patarroyo ME, Patarroyo MA
Abstract
Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great efforts aimed at developing better prevention (i.e., a highly effective vaccine), diagnosis, and treatment methods for malaria, no efficient solution to this disease has been advanced to dat...
Source: Journal of Immunology Research - February 22, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Current Drugs with Potential for Treatment of COVID-19: A Literature Review.
CONCLUSION: All examined treatments, although potentiality effective against COVID-19, need either appropriate drug development or clinical trial to be suitable for clinical use.
PMID: 32251618 [PubMed - as supplied by publisher]
Source: J Pharm Pharm Sci - April 7, 2020 Category: Drugs & Pharmacology Authors: Md Insiat Islam Rabby Tags: J Pharm Pharm Sci Source Type: research
Vaccines, Antibodies and Drug Libraries. The Possible COVID-19 Treatments Researchers Are Excited About
In early April, about four months after a new, highly infectious coronavirus was first identified in China, an international group of scientists reported encouraging results from a study of an experimental drug for treating the viral disease known as COVID-19.
It was a small study, reported in the New England Journal of Medicine, but showed that remdesivir, an unapproved drug that was originally developed to fight Ebola, helped 68% of patients with severe breathing problems due to COVID-19 to improve; 60% of those who relied on a ventilator to breathe and took the drug were able to wean themselves off the machines after 18...
Source: TIME: Health - April 14, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news
