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Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis
We report many of them for the first time. For the already described citrullinated proteins MBP, GFAP, and vimentin, we could identify additional citrullinated sites. The number of modified proteins in MS white matter was higher than control tissue. Citrullinated peptides are considered neoepitopes that may trigger autoreactivity. We used newly identified epitopes and previously reported immunodominant myelin peptides in their citrullinated and non-citrullinated form to address the recognition of CSF-infiltrating CD4+ T cells from 22 MS patients by measuring proliferation and IFN-γ secretion. We did not detect ...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

In search for globally disordered apo-parvalbumins: Case of parvalbumin β-1 from coho salmon.
Abstract Parvalbumin (PA) is a classical EF-hand calcium-binding protein of muscle, neuronal, and other tissues, and a major fish allergen. Although certain apo-PAs lack tertiary structure, functional implications of that feature and its structural prerequisites remain unclear. In a search for unstable PAs, we probed conformational stability of parvalbumin β-1 from coho salmon (csPA), a cold water fish species, using circular dichroism, scanning calorimetry, hydrophobic probe fluorescence, limited proteolysis, chemical crosslinking and dynamic light scattering techniques. Apo-csPA is shown to be mainly monomeric ...
Source: Cell Calcium - October 17, 2017 Category: Cytology Authors: Vologzhannikova AA, Khorn PA, Kazakov AS, Ismailov RG, Sokolov AS, Uversky VN, Permyakov EA, Permyakov SE Tags: Cell Calcium Source Type: research

Don ’t Be Afraid to Search in the Dark: Jon Lorsch Encourages Graduates to Consider New Perspectives
Jon Lorsch, from Swarthmore College’s class of 1990, returned to his alma mater in May to accept an honorary Doctor of Sciences degree for his accomplishments as a biochemist and his visionary leadership of NIGMS. During the university’s 147th commencement, he spoke to the 2019 graduating class, offering advice and examples of how we can look for opportunities in the least likely places. Watch the 5-minute video to hear Lorsch’s advice to the graduates—and all future scientists—to venture into the unknown in search of the next big advance in biomedical research. Transcript of Lorsch’s Speech: ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 19, 2019 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Scientific Process Source Type: blogs

Cellular mesenchymal epithelial transition (C-MET) gene copy number variation in gastric adenocarcinoma: A pilot search for new marker for targeted therapy in HER-2/neu resistance.
Abstract Increasing HER-2/neu resistance in gastric carcinoma has encouraged search for new biomarkers for targeted therapy. Cellular mesenchymal epithelial transition (C-MET) is one such tyrosine kinase inhibitor proposed for personalized salvage treatment. We determined frequency of C-MET gene copy number variation (CNV) by Fluorescent in-situ hybridization (FISH) in gastric adenocarcinoma (GAC) and sought its correlation with conventional clinicopathologic parameters. Dual-coloured FISH was done on 32 GAC cases. C-MET gene and centromere 7 signals were counted under fluorescent microscope and ratio was calculat...
Source: Indian Journal of Pathology and Microbiology - December 31, 2019 Category: Pathology Authors: Jain P, Wadhwa N, Joshi MK, Jain M, Halder A, Mishra K Tags: Indian J Pathol Microbiol Source Type: research

In search of a comprehensible set of endpoints for the routine monitoring of neurotoxicity in vertebrates: sensory perception and nerve transmission in zebrafish (Danio rerio) embryos.
Abstract In order to develop a test battery based on a variety of neurological systems in fish, three sensory systems (vision, olfaction, and lateral line) as well as nerve transmission (acetylcholine esterase) were analyzed in zebrafish (Danio rerio) embryos with respect to their suitability as a model for the screening of neurotoxic trace substances in aquatic ecosystems. As a selection of known or putative neurotoxic compounds, amidotrizoic acid, caffeine, cypermethrin, dichlorvos, 2,4-dinitrotoluene, 2,4-dichlorophenol, 4-nonylphenol, perfluorooctanoic acid, and perfluorooctane sulfonic acid were tested in the...
Source: Environmental Science and Pollution Research International - October 12, 2017 Category: Environmental Health Authors: Stengel D, Wahby S, Braunbeck T Tags: Environ Sci Pollut Res Int Source Type: research

De novo transcriptome analysis to search for sex-differentiation genes in the Siberian sturgeon.
Abstract The sturgeon family includes many species that are lucrative for commercial caviar production, some of which face critical conservation problems. The purpose of this study was to identify genes involved in gonadal sex differentiation in sturgeons, contributing to our understanding of the biological cycle of this valuable species. A high-quality de novo Siberian sturgeon gonadal transcriptome was built for this study using gonadal samples from undifferentiated fish at 3, 5, and 6 months of age; recently sex-differentiated fish at 9 months of age; and immature males and females at 14-17 months of age. Undif...
Source: General and Comparative Endocrinology - August 3, 2018 Category: Endocrinology Authors: Vizziano-Cantonnet D, Lasalle A, Di Landro S, Klopp C, Genthon C Tags: Gen Comp Endocrinol Source Type: research

Antibacterial substances produced by pathogen inhibitory gut bacteria in Labeo rohita: Physico-chemical characterization, purification and identification through MALDI-TOF mass spectrometry
This study was designed to purify and characterize the bioactive compound in the cell free supernatant (CFSs) of autochthonous gut bacteria (Bacillus methylotrophicus NR116240, B. amyloliquefaciens NR117946, Pseudomonas fluorescens NR113647 and B. licheniformis NR118996) isolated from rohu, Labeo rohita. CFSs were antagonistic to fish pathogenic Aeromonas spp., moderately thermo-tolerant and active in wide range of pH (5–11). Antibacterial activity of the CFSs was reduced by the action of proteases (e.g., Proteinase K and Trypsin), indicating proteinaceous nature of the bioactive compound like the bacteriocins. Three-ste...
Source: Microbial Pathogenesis - February 28, 2019 Category: Infectious Diseases Source Type: research

How to Stay Focused On the Search for Inner Freedom
The terms “being present” and “living in the now” have become clichés on the spiritual path and in the nondual tradition that has become increasingly popular in recent years. We speak of the power of now, the timeless moment, and that “there is only now.” In the positive thinking movement, we released sin as a stumbling block, then replaced it with the charge of negative thinking. Now our greatest put-down is the accusation of being distracted and therefore not present to what is. I am being slightly facetious, but the essential point remains: The key to awakening is in the awareness of what is. This is true ...
Source: World of Psychology - November 17, 2019 Category: Psychiatry & Psychology Authors: Psych Central Guest Author Tags: Publishers Spirituality & Health being present inner freedom Source Type: blogs

Divers found human remains and a submerged car in search for New Hampshire woman missing since 1978
New Hampshire Fish and Game search divers found human remains on Friday in a submerged car believed to belong to a woman who has been...
Source: Reuters: Health - August 7, 2021 Category: Consumer Health News Source Type: news

Starwatch: it is a great time to search the skies for Capricorn
This week the brightest objects in the constellation are the planet Saturn and the star Deneb AlgediIt is a great time of the year to search out Capricornus, the sea goat. This constellation was identified a few thousand years BC in Babylonian astronomy as the goat-fish, a hybrid creature with the body and head of a goat and the tail of a fish. In Greek mythology, the constellation is often associated with either Amalthea, who suckled Zeus, or Pan, the shepherd god.This week, the brightest object by far in the constellation is the planet Saturn. The chart shows the image looking south from London at midnight as 12 Septembe...
Source: Guardian Unlimited Science - September 12, 2022 Category: Science Authors: Stuart Clark Tags: Science Saturn Source Type: news

Nutrition and neurodevelopment: the search for candidate nutrients in the Seychelles Child Development Nutrition Study
Neurotoxicology. 2020 Dec;81:300-306. doi: 10.1016/j.neuro.2020.09.021. Epub 2020 Oct 14.ABSTRACTThis review examines the role of nutrients in child development and outlines the key nutrients identified as potentially important to neurodevelopment among high fish consumers in the Seychelles Child Development Nutrition Study (SCDNS). It describes the clinical assessment of these nutrients in the blood and breast milk samples collected from the cohort of 300 pregnant women who were recruited, at their first antenatal visit, on the SCDNS. These key nutrients include the long chain polyunsaturated fatty acids (LCPUFA), docosoh...
Source: Neurotoxicology - March 20, 2021 Category: Neurology Authors: J J Strain Maxine P Bonham Emeir M Duffy Julie M W Wallace Paula J Robson Thomas W Clarkson Conrad Shamlaye Source Type: research

Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a "fingerprint"
Environ Sci Pollut Res Int. 2021 Oct 13. doi: 10.1007/s11356-021-16354-4. Online ahead of print.ABSTRACTThe fish embryo acute toxicity (FET) test with the zebrafish (Danio rerio) embryo according to OECD TG 236 was originally developed as an alternative test method for acute fish toxicity testing according to, e.g., OECD TG 203. Given the versatility of the protocol, however, the FET test has found application beyond acute toxicity testing as a common tool in environmental hazard and risk assessment. Whereas the standard OECD guideline is restricted to four core endpoints (coagulation as well as lack of somite formation, h...
Source: Environmental Science and Pollution Research International - October 13, 2021 Category: Environmental Health Authors: Rebecca von Hellfeld Pauline Pannetier Thomas Braunbeck Source Type: research

Hypoxia causes sex-specific hepatic toxicity at the transcriptome level in marine medaka (Oryzias melastigma).
Abstract Hypoxia, a low environmental oxygen level, is a common problem in the ocean globally. Hypoxia has been known to cause disruption to the endocrine system of marine organisms in both laboratory and field studies. Our previous studies have demonstrated the sex-specific response to hypoxia in the neural and reproductive systems of marine fish. In the current report, we aim to study the sex-specific hepatic response of fish at the transcriptome level to hypoxic stress. By using a comparative transcriptome analysis, followed by a systematic bioinformatics analysis including Database for Annotation, Visualizatio...
Source: Aquatic Toxicology - May 18, 2020 Category: Toxicology Authors: Lai KP, Tam N, Wang SY, Lin X, Chan TF, Au DWT, Wu RSS, Kong RYC Tags: Aquat Toxicol Source Type: research