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Total 101966 results found since Jan 2013.
Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury
CONCLUSIONS: Taken together, Fgl2 hastens the development of alcoholic liver injury by mediating PKM2 dependent aerobic glycolysis in proinflammatory macrophages. Strategies that inhibiting proinflammatory macrophage activation by silencing Fgl2 might be a potential therapeutic intervention for alcoholic liver injury.PMID:37734200 | DOI:10.1016/j.intimp.2023.110957
Source: International Immunopharmacology - September 21, 2023 Category: Allergy & Immunology Authors: Xue Hu Xiaoyang Wan Yuting Diao Zhe Shen Zhongwei Zhang Peng Wang Danqin Hu Xiaojing Wang Weiming Yan Chaohui Yu Xiaoping Luo Hongwu Wang Qin Ning Source Type: research
The effect of spatial separation on food and drink choices from an online menu
Eat Behav. 2023 Sep 17;51:101816. doi: 10.1016/j.eatbeh.2023.101816. Online ahead of print.ABSTRACTEmerging research suggests that modifying the presentation context of healthy food items can subtly 'nudge' individuals to make healthier choices. The present study aimed to investigate the effect of spatial separation between high and low nutritional value items on food and drink choices from an online fast-food menu. Participants (N = 210 women) were presented with one of three pictorial menus in which high nutritional value food and drink items were presented spatially mixed, grouped, or separate from low nutritional value...
Source: Eating Behaviors - September 21, 2023 Category: Eating Disorders & Weight Management Authors: Amelia Kingham Eva Kemps Ivanka Prichard Marika Tiggemann Source Type: research
Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis
This study was designed to investigate the effects and underlying mechanisms of linc00657 in atherogenesis. The results showed that ox-LDL treatment significantly induced pyroptosis in human THP-1-derived macrophages. The secretion levels of LDH and pro-inflammatory factors were markedly enhanced, and the integrity of plasma membranes was disrupted in ox-LDL-treated THP-1-derived macrophages. These effects were significantly compensated after transfection with linc00657 siRNA and became more evident by linc00657 overexpression. Moreover, the effects of linc00657 overexpression on pyroptosis of THP-1-derived macrophages can...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yin Liang Xiao-Dan Xu Xi Xu Yang-Bo Cai Zi-Xian Zhu Lin Zhu Kun Ren Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Inhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin, naringenin, myricetin, ampelopsin and their conjugated metabolites
In this study, we examined the impacts of luteolin, naringenin, myricetin, ampelopsin, and their sulfate/glucuronide derivatives on XO-catalyzed xanthine and 6-mercaptopurine oxidations employing in vitro enzyme incubation assays and molecular modeling studies. Our major results/conclusions are the following: (1) Sulfate metabolites were stronger while glucuronic acid derivatives were weaker inhibitors of XO compared to the parent flavonoids. (2) Naringenin, ampelopsin, and their metabolites were weak inhibitors of the enzyme. (3) Luteolin, myricetin, and their sulfates were highly potent inhibitors of XO, and the glucuron...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Orsolya Bal ázs Ágnes Dombi Bal ázs Z Zsidó Csaba Het ényi Kate řina Valentová R óbert G Vida Mikl ós Poór Source Type: research
Relationships of pregnancy and postpartum diet quality with offspring birth weight and weight status through 12 months
CONCLUSIONS: Maternal diet quality during pregnancy (and during postpartum in mothers who breastfed for a longer duration) was inversely related to LGA and weight status indicators from birth through 12 months. Increasing maternal diet quality may have use for promoting healthy infant weight development.PMID:37731285 | DOI:10.1002/oby.23891
Source: Obesity - September 21, 2023 Category: Eating Disorders & Weight Management Authors: Leah Lipsky Jenna Cummings Anna Maria Siega-Riz Tonja Nansel Source Type: research
Weight-independent effects of Roux-en-Y gastric bypass surgery on remission of nonalcoholic fatty liver disease in mice
CONCLUSIONS: RYGB improved whole-body composition and hepatic lipid homeostasis to a greater extent than CR in mice. RYGB was associated with discrete remodeling of the hepatic transcriptome, suggesting that surgery may be mechanistically additive to CR.PMID:37731222 | DOI:10.1002/oby.23876
Source: Obesity - September 21, 2023 Category: Eating Disorders & Weight Management Authors: Christopher L Axelrod Ingeborg Langohr Wagner S Dantas Elizabeth C Heintz Bolormaa Vandanmagsar Shengping Yang Elizabeth R M Zunica R Leigh Townsend Vance L Albaugh Hans-Rudolf Berthoud John P Kirwan Source Type: research
Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice
J Lipid Res. 2023 Sep 19:100449. doi: 10.1016/j.jlr.2023.100449. Online ahead of print.ABSTRACTActivation of brown adipose tissue (BAT) contributes to energy dissipation and metabolic health. Although mineralocorticoid receptor (MR) antagonists have been demonstrated to improve metabolism under obesity, the underlying mechanisms remain incompletely understood. We aimed to evaluate the role of BAT MR in metabolic regulation. After 8 weeks of high fat diet (HFD) feeding, BAT MR knockout (BMRKO) mice manifested significantly increased body weight, fat mass, serum fasting glucose and impaired glucose homeostasis compared to li...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Chu-Mao Chen Xiao-Qian Meng Hong Zhu Ting Liu Yuan Liu Lu-Jun Zhou Guo-Dong Zhu Xiao-Bei Chen Xu-Guang Guo Sheng-Zhong Duan Source Type: research
Aging Rate Indicators as Speedometers for Aging Research
Is it possible to measure the pace of aging at any given moment? Are there biomarkers that reveal not the biological age of the individual, but rather how fast that biological age is changing? The field is presently focused on developing measures of biological age, such as the extensive work on epigenetic clocks. Some information about pace of aging might be inferred from whether biological age is higher or lower than chronological age, assuming a biological age measurement that is actually accurate, something that still a topic for contention. But that doesn't say anything about the momentary pace of aging at any given ti...
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Energy levels and lysine, calcium and phosphorus adjustments on broiler nutrient digestibility and performance
An Acad Bras Cienc. 2023 Sep 18;95(4):e20191391. doi: 10.1590/0001-3765202320191391. eCollection 2023.ABSTRACTChicken broilers digestibility and performance fed with different ME levels, with and without adjustments of digestible lysine, calcium, and available phosphorus, were evaluated. For digestibility, 210 male Cobb 500 chicken broilers were used and distributed into a 3x2+1 factorial arrangement, with three ME levels (3050; 3125 and 3200 kcal/kg) with and without nutrient adjustment, plus one control treatment (2975 kcal ME/kg), totaling seven treatments including six repetitions with five birds into each repetition. ...
Source: An Acad Bras Cienc - September 20, 2023 Category: Science Authors: Victor Emanuel M Feitosa Camilla M Silva Valdir Ribeiro J únior Claudio Jose P DE Oliveira Jos é Geraldo DE Vargas Júnior Ant ônio P DE Barros Neto Luiz Fernando T Albino Claudson O Brito Source Type: research
Functional feeding groups of Chironomidae (Diptera: Nematocera) and their spatial variation in an intermittent hill stream (Ventana Stream, Buenos Aires, Argentina)
In this study, we analyzed the gut contents of this insect family with an aim at establishing their diet in an intermittent stream in the Ventania-Hill system. We sampled three sites with different habitat characteristics (i. e., altitude, substrate type, and current velocity). Of the total of nine taxa were recorded, the only one present at all sites was Corynoneura sp. 1. The food items found were detritus, diatoms, filamentous chlorophytes, euglenophytes, vascular plants, fungi, and animal remains. Most of the taxa could be classified as gathering collectors, with those having a higher proportion of detritus in the gut ...
Source: An Acad Bras Cienc - September 20, 2023 Category: Science Authors: Carolina Ocon Augusto Siri Paula Altieri Mariano Donato Source Type: research
Healthy lifestyle promotion via digital self-help for mental health patients in primary care: a pilot study including an embedded randomized recruitment trial
CONCLUSIONS: Recruitment routines seemed to be decisive for reaching as many patients as possible. The relatively low rate of unhealthy lifestyle behaviors and small effect sizes suggests that the intervention may only suit patients at risk.TRIAL REGISTRATION: ClinicalTrials.gov NCT03691116 (01/10/2018), focusing on the embedded trial. Retrospectively registered for the first clinic and prospectively for the second clinic.PMID:37728142 | DOI:10.1017/S146342362300049X
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Karoline Kolaas Erland Axelsson Erik Hedman-Lagerl öf Anne H Berman Source Type: research
Shuttle between arginine and lysine: influence on cancer immunonutrition
Amino Acids. 2023 Sep 20. doi: 10.1007/s00726-023-03327-9. Online ahead of print.ABSTRACTAmino acids which are essential nutrients for all cell types' survival are also recognised to serve as opportunistic/alternative fuels in cancers auxotrophic for specific amino acids. Accordingly, restriction of amino acids has been utilised as a therapeutic strategy in these cancers. Contrastingly, amino acid deficiencies in cancer are found to greatly impair immune functions, increasing mortality and morbidity rates. Dietary and supplemental amino acids in such conditions have revealed their importance as 'immunonutrients' by modulat...
Source: Amino Acids - September 20, 2023 Category: Biochemistry Authors: R Sindhu M Supreeth Shashanka K Prasad M Thanmaya Source Type: research
Hyperpolarized 1- < sup > 13 < /sup > Cpyruvate Magnetic Resonance Spectroscopy Shows That Agmatine Increased Lactate Production in the Brain of Type 2 Diabetic Mice
CONCLUSION: Agmatine influences the NADH/NAD+ redox state in the brains of T2DM mice, which may be connected with enhanced cognitive performance and increased conversion of HP [1-13C]pyruvate to HP [1-13C]lactate.PMID:37727922 | DOI:10.3349/ymj.2022.0554
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: Young-Suk Choi Jae Eun Song Eosu Kim Chul Hoon Kim Jong Eun Lee Ho-Taek Song Source Type: research
The positive impact of lifestyle intervention on selected mio- and chemokines levels in prepubertal children with obesity
CONCLUSIONS: Personalized diet modification and regular, daily exercises may positively influence on the levels of irisin and chemerin.PMID:37728459 | DOI:10.5114/pedm.2023.127273
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Agnieszka Kozio ł-Kozakowska Ma łgorzata Wójcik Dominika Janu ś Jerzy Starzyk Source Type: research
