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Total 83 results found since Jan 2013.

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Discovery could lead to better recovery after stroke
UCLA researchers have identified a molecule that, after a stroke, signals brain tissue to form new connections to compensate for the damage and initiate repairs to the brain. The finding could eventually lead to a new treatment to promote brain repair and functional recovery in people who have suffered a stroke, which is the leading cause of serious long-term disability in adults. The five-year study, performed in an animal model, was the first to identify growth differentiation factor 10, or GDF10, a molecule that previously had no known role in the adult brain, said Dr. S. Thomas Carmichael, the study’s senior author ...
Source: UCLA Newsroom: Health Sciences - October 26, 2015 Category: Universities & Medical Training Source Type: news

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.
CONCLUSIONS: Heat stroke-induced coagulopathy may be a driving mechanistic force in heat stroke pathology, especially when exacerbated by prior infection. Coagulation markers may serve as accessible biomarkers for heat stroke severity and therapeutic strategies. PMID: 32367690 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - May 3, 2020 Category: Hematology Authors: Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR Tags: J Thromb Haemost Source Type: research

Post Stroke Cognitive Impairment and Hippocampal Neurovascular Remodeling: The Impact of Diabetes and Sex.
Abstract Diabetes increases the risk and severity of cognitive impairment, especially after ischemic stroke. Pathological remodeling of the cerebrovasculature has been postulated to contribute to poor neuronal repair and worsened cognitive deficits in diabetes. However, little is known about the effect of diabetes on the vascularization of hippocampus, a domain critical to memory and learning. Therefore we had two aims for this study: 1) to determine the impact of diabetes on hippocampal neurovascular remodeling and the resulting cognitive impairment after stroke using two models with varying disease severity, and...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 17, 2018 Category: Physiology Authors: Ward R, Valenzuela JP, Li W, Dong G, Fagan SC, Ergul A Tags: Am J Physiol Heart Circ Physiol Source Type: research

Pharmacological Enhancement of Stroke Recovery
AbstractPurpose of ReviewThis review aims to discuss the recent literature relating to drugs for stroke recovery and to identify some of the challenges in conducting translational research for stroke recovery.Recent FindingsAdvances in our understanding of neural repair mechanisms in pre-clinical stroke models have provided insights into potential targets for drugs that enhance the repair/recovery process. Few drugs that act on serotonergic and dopaminergic systems have been tested in humans with mixed results. The FOCUS trial, a phase III study of early administration of fluoxetine for stroke recovery, failed to replicate...
Source: Current Neurology and Neuroscience Reports - May 29, 2019 Category: Neuroscience Source Type: research

Varied Overground Walking Training Versus Body-Weight-Supported Treadmill Training in Adults Within 1 Year of Stroke: A Randomized Controlled Trial
Conclusions: In this sample of community-dwelling adults within 1 year of stroke, a 15-session program of varied overground walking-focused training was not superior to a BWSTT program of equal frequency, duration, and in-session step activity.
Source: Neurorehabilitation and Neural Repair - March 25, 2015 Category: Neurology Authors: DePaul, V. G., Wishart, L. R., Richardson, J., Thabane, L., Ma, J., Lee, T. D. Tags: Clinical Research Articles Source Type: research

Predicting Motor Sequence Learning in Individuals With Chronic Stroke
Conclusion. Nonlinear information extracted from multiple time points across practice, specifically the rate of motor skill acquisition during practice, relates strongly with changes in motor behavior at the retention test following practice and could be used to predict optimal doses of practice on an individual basis.
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Wadden, K. P., Asis, K. D., Mang, C. S., Neva, J. L., Peters, S., Lakhani, B., Boyd, L. A. Tags: Original Research Articles Source Type: research

Understanding Adaptive Motor Control of the Paretic Upper Limb Early Poststroke: The EXPLICIT-stroke Program
Conclusions. Our results suggest that restitution of motor control by dissociation of shoulder and elbow movements occurs mainly early poststroke. However, compared with healthy adults, most patients did not achieve fully dissociated upper limb movements at 26 weeks poststroke, suggesting that upper limb motor control after stroke remains adaptive.
Source: Neurorehabilitation and Neural Repair - October 7, 2013 Category: Neurology Authors: van Kordelaar, J., van Wegen, E. E. H., Nijland, R. H. M., Daffertshofer, A., Kwakkel, G. Tags: Clinical Research Articles Source Type: research

A Mirror Therapy-Based Action Observation Protocol to Improve Motor Learning After Stroke
Conclusion. The present study showed that a mirror therapy–based AO protocol contributes to motor learning after stroke.
Source: Neurorehabilitation and Neural Repair - June 25, 2015 Category: Neurology Authors: Harmsen, W. J., Bussmann, J. B. J., Selles, R. W., Hurkmans, H. L. P., Ribbers, G. M. Tags: Clinical Research Articles Source Type: research

The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after ischemic stroke.
Abstract Ischemic stroke is a devastating condition with few therapeutic interventions available. The neuroprotective compound P7C3-A20 inhibits mature neuronal cell death while also increasing the net magnitude of postnatal neurogenesis in models of neurodegeneration and acute injury. P7C3 compounds enhance flux of nicotinamide adenine dinucleotide (NAD) in mammalian cells, a proposed therapeutic approach to treating cerebral ischemia. The effectiveness of P7C3-A20 treatment on chronic histopathological and behavioral outcomes and neurogenesis after ischemic stroke has not previously been established. Here, a tra...
Source: Experimental Neurology - January 7, 2017 Category: Neurology Authors: Loris ZB, Pieper AA, Dalton Dietrich W Tags: Exp Neurol Source Type: research

Recovery After Stroke
This article describes restorative therapies to improve patient outcomes after stroke. These therapies contrast with acute stroke treatments such as recombinant tissue plasminogen activator (rtPA) and thrombectomy that target clots, aim to salvage threatened brain tissue to limit injury, and have a time window measured in hours. Restorative therapies target the brain, aim to promote plasticity within surviving brain tissue, and have a time window measured in days to weeks or longer. RECENT FINDINGS A number of drugs are under study. Preclinical studies are providing attractive therapeutic candidates for translation, suc...
Source: CONTINUUM: Lifelong Learning in Neurology - April 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway
CONCLUSION: LW33 inhibited cell apoptosis and promoted neuronal repair to alleviate OGD/R and MCAO induced pathological alterations via the cGMP/PKG/CREB pathway, indicating that LW33 may be a promising therapeutic target for ischemic stroke.PMID:35490726 | DOI:10.1016/j.ejphar.2022.174987
Source: European Journal of Pharmacology - May 1, 2022 Category: Drugs & Pharmacology Authors: Jia-Yi You Xin-Wei Liu Ying-Xia Bao Zheng-Nan Shen Quan Wang Gong-Yun He Jing Lu Ji-Guo Zhang Jian-Wen Chen Pei-Qing Liu Source Type: research

Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke
Biomaterials. 2022 Nov 10;291:121904. doi: 10.1016/j.biomaterials.2022.121904. Online ahead of print.ABSTRACTOxidative stress and mitochondrial damage are the main mechanisms of ischemia-reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free radical scavenging ability were used as carriers to load dl-3-n-butylphthalide (NBP-CeO2 NPs) for the combined treatment of ischemic stroke. NBP-CeO2 NPs could eliminate reactive oxygen species (ROS) in mouse brain microvascular endothelial cells and hippocampal neurons after oxygen-glucose deprivation/reoxygenation (OGD/R), and also save mitochond...
Source: Biomaterials - November 20, 2022 Category: Materials Science Authors: Xiang Li Zhihui Han Tianyi Wang Cheng Ma Haiying Li Huali Lei Yuqi Yang Yuanjie Wang Zifan Pei Zhuang Liu Liang Cheng Gang Chen Source Type: research