A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway

CONCLUSION: LW33 inhibited cell apoptosis and promoted neuronal repair to alleviate OGD/R and MCAO induced pathological alterations via the cGMP/PKG/CREB pathway, indicating that LW33 may be a promising therapeutic target for ischemic stroke.PMID:35490726 | DOI:10.1016/j.ejphar.2022.174987

Source: European Journal of Pharmacology - May 1, 2022 Category: Drugs & Pharmacology Authors: Jia-Yi You Xin-Wei Liu Ying-Xia Bao Zheng-Nan Shen Quan Wang Gong-Yun He Jing Lu Ji-Guo Zhang Jian-Wen Chen Pei-Qing Liu Source Type: research