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Total 496 results found since Jan 2013.

Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke
CONCLUSIONS: Our study demonstrated that BHD exerted the effect of treating IS by regulating multitargets and multichannels with multicomponents through the method of network pharmacology and molecular docking.PMID:33727944 | PMC:PMC7937485 | DOI:10.1155/2021/8815447
Source: Evidence-based Complementary and Alternative Medicine - March 17, 2021 Category: Complementary Medicine Authors: Qiang Gao Danfeng Tian Zhenyun Han Jingfeng Lin Ze Chang Dandan Zhang Dayong Ma Source Type: research

Chinese herbal injections combined with rt-PA intravenous thrombolysis for acute ischemic stroke: A systematic review and meta-analysis protocol
Conclusion: The conclusion of the meta-analysis will provide a basis for judging whether CHIs combined with intravenous thrombolysis is an effective measure for the treatment of AIS. Ethics and dissemination: Ethical approval is not needed because this study will be based on data that already published. We will publish the findings of this study in a peer-reviewed journal and related conferences. PROSPERO registration number: CRD42020215546.
Source: Medicine - March 12, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

UPLC-ESI-Q-TOF/MS based metabolic profiling of protosappanin B in rat plasma, bile, feces, urine and intestinal bacteria samples
CONCLUSION: The results showed that the small intestinal and biliary routes play an important role in the clearance and excretion of PTB. The main sites of metabolism in the PTB chemical structure were the phenolic hydroxyl and the side-chains on the eight-element ring.PMID:33605854 | DOI:10.2174/1389200222666210219123846
Source: Current Drug Metabolism - February 19, 2021 Category: Drugs & Pharmacology Authors: Wei-Ying Chen Guang-Yan Liang Zuo-Liang Zheng Yun-Shan Wu Fang-Fang Xu Bo Liu De-An Guo Source Type: research

UPLC-ESI-Q-TOF/MS based metabolic profiling of protosappanin B in rat plasma, bile, feces, urine and intestinal bacteria samples.
CONCLUSION: The results showed that the small intestinal and biliary routes play an important role in the clearance and excretion of PTB. The main sites of metabolism in the PTB chemical structure were the phenolic hydroxyl and the side-chains on the eight-element ring. PMID: 33605854 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - February 19, 2021 Category: Drugs & Pharmacology Authors: Chen WY, Liang GY, Zheng ZL, Wu YS, Xu FF, Liu B, Guo DA Tags: Curr Drug Metab Source Type: research

Withania Somnifera in Neurological Disorders: Ethnopharmacological Evidence, Mechanism of Action and its Progress in Delivery Systems.
Conclusion: The current review substantially deciphered the protective role of W. somnifera against various neurological disorders. However, future studies are further required better to understand the molecular mechanisms behind their neuroprotective nature. PMID: 33538666 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - February 3, 2021 Category: Drugs & Pharmacology Authors: Syed AA, Reza MI, Singh P, Thombre GK, Gayen JR Tags: Curr Drug Metab Source Type: research

Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway.
Abstract Post-stroke depression(PSD) is a common complication and associates with poor physical recovery, low quality of life and high mortality after cerebral infarction. However, the pathogenesis of PSD have not been elucidated thoroughly now, and there is a lack of effective therapy in clinic. It reported that Saikosaponin A, one of the main constituents from Chinese herb Bupleurum chinense, has pharmacological activity in anti-depression. Thus, this study aimed to elucidate the potential effects and mechanisms of Saikosaponin A on the depression-like behavior after cerebral ischemic injury in rats. The rat mod...
Source: Behavioural Brain Research - January 22, 2021 Category: Neurology Authors: Wang AR, Mi LF, Zhang ZL, Hu MZ, Zhao ZY, Liu B, Li YB, Zheng S Tags: Behav Brain Res Source Type: research

Network pharmacology reveals the mechanism of activity of Tongqiao Huoxue Decoction Extract against middle cerebral artery occlusion-induced cerebral ischemia reperfusion injury
Some clinical therapies such as tissue repair by replacing injured with functional tissues have been reported, yet there is the great explore potential for traditional herbal-induced regeneration with good safety. Tongqiao Huoxue Decoction (TQHXD), a well-known classical traditional Chinese Medicinal formula, has been widely used for clinical treatment of stroke. However, biological activity and mechanisms of action of its constituents towards conferring protection against cerebral ischemia reperfusion (I/R) injury remain unclear. In this present study, we evaluated TQHXD quality using HPLC, then screened for its potential...
Source: Frontiers in Pharmacology - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Therapeutic effect of Chinese herbal medicines for post-stroke depression: A meta-analysis of randomized controlled trials
This study aimed to assess the efficacy and safety of combination of CHM with routine western medicines versus routine western medicines alone in patients with post-stroke depression (PSD). Methods: Electronic databases such as PubMed, EmBase, Cochrane library, and China National Knowledge Infrastructure were systematically searched from inception till October 2019. Studies designed as randomized controlled trials (RCTs) and that investigated the therapeutic effects of CHM plus routine western medicines (CHM group) versus routine western medicines alone (control group) in PSD patients were eligible. The relative ris...
Source: Medicine - January 8, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPAR γ pathway after cerebral ischemia/reperfusion injury in rats.
Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats. Int Immunopharmacol. 2021 Jan 08;92:107335 Authors: Li L, Gan H, Jin H, Fang Y, Yang Y, Zhang J, Hu X, Chu L Abstract Microglia/macrophages play a dual role in brain injury and repair following cerebral ischemia/reperfusion. Promoting microglia/macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype has been considered as a potential treatment for ischemic stroke. Astragaloside IV (AS-IV) is a pr...
Source: International Immunopharmacology - January 8, 2021 Category: Allergy & Immunology Authors: Li L, Gan H, Jin H, Fang Y, Yang Y, Zhang J, Hu X, Chu L Tags: Int Immunopharmacol Source Type: research

Molecules, Vol. 26, Pages 302: Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice
Conclusions: The results of this study demonstrated that the herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD in HFD-induced mouse model.
Source: Molecules - January 8, 2021 Category: Chemistry Authors: Ahtesham Hussain Jin Sook Cho Jong-Seok Kim Young Ik Lee Tags: Article Source Type: research

Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury.
In this study, middle cerebral artery occlusion (MCAO) was induced in rats with thrombi generated by thread and subsequently treated with PN. After that, staining with 2,3,5-triphenyltetrazolium chloride was employed to evaluate the infarcted area, and electron microscopy was used to assess ultrastructural changes of the neurovascular unit. RNA-Seq was performed to determine the differential expressed genes (DEGs) which were then verified by qPCR. In total, 817 DEGs were identified to be related to the therapeutic effect of PN on stroke recovery. Further analysis by Gene Oncology analysis and Kyoto Encyclopedia of Genes an...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Safety of co-administration of herbal and conventional medicines on liver and kidney function in stroke patients: A single-center retrospective study
Publication date: Available online 6 December 2020Source: PhytomedicineAuthor(s): Sang-Hwa Lee, Seo-Young Kim, Seung-Bo Yang, Chul Jin, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko
Source: Phytomedicine - December 8, 2020 Category: Drugs & Pharmacology Source Type: research

Nigella Sativa (Black seeds), a Potential herb for the Pharmacotherapeutic Management of Hypertension - A Review.
Authors: Pakkir Maideen NM, Balasubramanian R, Ramanathan S Abstract Hypertension is one of the leading risk factors of stroke, myocardial infarction and untimely death. The prevalence of hypertension is extremely high among the global population and many of them depend on modern medicines to manage their blood pressure. The modern antihypertensive medications include angiotensin converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), diuretics, betaadrenergic blockers, direct renin inhibitors, direct acting vasodilators, alpha-adrenergic blockers and centrall...
Source: Current Cardiology Reviews - November 13, 2020 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research

Multimodal Magnetic Resonance Imaging and Therapeutic Intervention With Yi-nao-jie-yu Decoction in a Rat Model of Post-stroke Depression
Post-stroke depression (PSD) is the most common neuropsychiatric complication after a stroke, though its neuropathological characteristics have not been fully elucidated. Comprehensive and non-invasive magnetic resonance (MR) assessment techniques are urgently needed for current research, as diffusion tensor imaging (DTI), arterial spin labeling (ASL), and magnetic resonance spectroscopy (MRS) can allow for a comprehensive assessment of neuropathological changes in the brain. These techniques can provide information about microscopic tissue integrity, cerebral perfusion, and cerebral metabolism, and can serve as powerful t...
Source: Frontiers in Psychiatry - November 4, 2020 Category: Psychiatry Source Type: research

A Network Pharmacology-Based Identification Study on the Mechanism of Xiao-Xu-Ming Decoction for Cerebral Ischemic Stroke.
Conclusion: This study initially clarified the main targets and pathways of XXMD in the treatment of CIS, which can lay the foundation for further research on its pharmacological effects. PMID: 33133212 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - November 3, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research