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Nutrition: Antidoxidants
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Total 731 results found since Jan 2013.
Gut Flora Mediates the Rapid Tolerance of Electroacupuncture on Ischemic Stroke by Activating Melatonin Receptor through Regulating Indole-3-Propionic Acid
This study aimed to clarify the mechanisms of action of treatments of cerebral ischemic stroke from the perspective of gut microecology. We used a mouse model and cell cultures to investigate the effects of EA on the intestinal microflora in mice models of middle cerebral artery occlusion (MCAO) and the mechanisms underlying the antioxidant activities of metabolites. Fecal microbiota transplantation (FMT) was used to validate the roles of gut microbiota. Metabolomic analysis was performed to characterize the metabolic profile differences between the mice in the EA + MCAO and MCAO groups. Gavaging with feces relieved brain ...
Source: The American Journal of Chinese Medicine - April 27, 2022 Category: Complementary Medicine Authors: Shan Li Xiaoyong Zhao Feihong Lin Xuqing Ni Xia Liu Chang Kong Xinyu Yao Yunchang Mo Qinxue Dai Junlu Wang Source Type: research
Association between dietary antioxidant capacity and atherosclerotic carotid stenosis in patients with ischemic stroke
CONCLUSIONS: DTAC may influence the initiation and development of atherosclerosis, and, therefore, the risk of ischemic stroke.PMID:37210776 | DOI:10.1016/j.jstrokecerebrovasdis.2023.107148
Source: Atherosclerosis - May 21, 2023 Category: Cardiology Authors: Jizi Ma Xuerong Jia Yaqian Xia Min Peng Yantong Chen Jingjing Cai Xinfeng Liu Gelin Xu Source Type: research
Dietary Flavonoid Intake and Carotid Calcification in Patients with Ischemic Stroke
CONCLUSION: Dietary flavonoid intake is associated with carotid calcification, and, therefore, may influence the risk of stroke occurrence and recurrence.PMID:37524067 | DOI:10.1159/000532117
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: Tao Mou Xuerong Jia Min Peng Xiang Li Yaqian Xia Yantong Chen Qing Wang Xiaoke Wang Xinfeng Liu Gelin Xu Source Type: research
Naringenin prevents ischemic stroke damage via anti-apoptotic and anti-oxidant effects.
This study aimed to investigate the anti-apoptotic and anti-oxidant effects of naringenin on ischemic stroke. In vitro, cortical neuron cells isolated from the brains of neonatal Sprague-Dawley rats were randomly divided into control, oxygen and glucose deprivation/reperfusion (OGD/Rep), NAR-L, NAR-M and NAR-H groups. MTT and RT-PCR were used for cell proliferation and apoptosis-related proteins analyses. The effects of NAR on the Nrf2 signaling pathway were investigated using transfection approaches. Differences in mitochondrial dysfunction were analyzed by flow cytometry. In vivo, middle cerebral artery occlusion (MCAO) ...
Source: Pharmacological Reports - April 28, 2017 Category: Drugs & Pharmacology Authors: Wang K, Chen Z, Huang J, Huang L, Luo N, Liang X, Liang M, Xie W Tags: Clin Exp Pharmacol Physiol Source Type: research
Correlation of Serum Nitric Oxide (NO) with Glasgow Coma Scale (GCS) in Acute Ischemic Stroke Patient: A Study in North India
AbstractNitric oxide (NO) is one of the key players in the pathogenesis of ischemic stroke. Limited reports are available about the serum level of NO and their correlation with Glasgow Coma Scale (GCS) score in acute (<24 h) ischemic stroke (AIS) patients. A hospital based, cross sectional study was done in North Indian population to find out correlation of serum NO and GCS in AIS patients. 50 patients of AIS and 25 healthy controls were chosen for the study. Serum NO level was measured by ELISA and GCS scores were assessed by a neurologist. Pearson correlation coefficients were analyzed to look for the relationship b...
Source: Indian Journal of Clinical Biochemistry - July 5, 2017 Category: Biochemistry Source Type: research
Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways.
This study was designed in order to investigate the effects between rehabilitation training on the apoptosis of nerve cells and the recovery of neural and motor functions of rats with ischemic stroke by way of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and nuclear factor E2-related factor 2/antioxidant responsive element (Nrf2/ARE) signaling pathways. In total, 110 healthy adult male Sprague-Dawley (SD) rats were selected in order to take part in this study. Ninety SD rats were used in order to establish the middle cerebral artery occlusion (MCAO), among which 80 rats were randomly assigned as part of th...
Source: Brain Research Bulletin - August 23, 2017 Category: Neurology Authors: Jin XF, Wang S, Shen M, Wen X, Han XR, Wu JC, Tang GZ, Wu DM, Lu J, Zheng YL Tags: Brain Res Bull Source Type: research
Development of a Reactive Oxygen Species-Sensitive Nitric Oxide Synthase Inhibitor for the Treatment of Ischemic Stroke.
In this study, the nitrone 5was designed such that its decomposition product is a NOS inhibitor, 6, effectively leading to NOS inhibition specifically at the site of ROS production. The ability of 5to spin-trap radicals and decompose to 6 was observed using EPR and LC-MS/MS. The pro-drug concept was tested in vitro by measuring cell viability and 6 formation in SH-SY5Y cells subjected to oxygen glucose deprivation (OGD). 5 was found to be more efficacious and more potent than PBN, and was able to increase phospho-Akt while reducing nitrotyrosine and cleaved caspase-3 levels. 6 treatment, but not 5, was found to decrease NO...
Source: Free Radical Biology and Medicine - December 21, 2017 Category: Biology Authors: Nash KM, Schiefer IT, Shah ZA Tags: Free Radic Biol Med Source Type: research
AMPA receptor antagonist perampanel ameliorates post-stroke functional and cognitive impairments
Publication date: Available online 5 July 2018Source: NeuroscienceAuthor(s): Masataka Nakajima, Satoshi Suda, Kota Sowa, Yuki Sakamoto, Chikako Nito, Yasuhiro Nishiyama, Junya Aoki, Masayuki Ueda, Shoji Yokobori, Marina Yamada, Hiroyuki Yokota, Takashi Okada, Kazumi KimuraAbstractPerampanel (PER), a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor antagonist, clinically used for seizure control, has been reported to exert neuroprotective effects in experimental models of neurodegenerative diseases. However, few studies have investigated the therapeutic effects of PER in brain injury including stro...
Source: Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Green Tea and Red Tea from Camellia sinensis Partially Prevented the Motor Deficits and Striatal Oxidative Damage Induced by Hemorrhagic Stroke in Rats.
In this study, we investigated the effects of supplementation with green tea and red tea from Camellia sinensis on motor deficits and striatum oxidative damage in rats submitted to hemorrhagic stroke (ICH). Male Wistar rats were supplemented with green tea, red tea, or vehicle for 10 days prior to ICH induction. After injury, the rats were submitted to motor tests (open field for locomotion, rotarod for balance, and neurological deficit scale (NDS)) 1, 3, and 7 days after ICH induction, while the tea supplementation was maintained. Subsequently, the rats were euthanized to striatal tissue dissection for biochemical analyze...
Source: Neural Plasticity - September 5, 2018 Category: Neurology Authors: Sosa PM, de Souza MA, Mello-Carpes PB Tags: Neural Plast Source Type: research
Post-stroke depression: Antidepressive effects of a chemically characterized maqui berry extract in a mouse model (Aristotelia chilensis (molina) stuntz).
This study aimed to evaluate the antidepressive-like effects and in vivo antioxidant activity of a chemically characterized maqui berry (Aristotelia chilensis (Molina) Stuntz) extract obtained from an optimized extraction method, on a murine PSD model. The extraction process was optimized to maximize anthocyanin content, and the phytochemical profile of the extract was evaluated using a multi-methodological approach including a liquid chromatographic method coupled with mass spectrometry and nuclear magnetic resonance spectroscopy. The antidepressive-like activity was investigated through despair swimming and tail suspensi...
Source: Food and Chemical Toxicology - April 21, 2019 Category: Food Science Authors: Di Lorenzo A, Sobolev AP, Nabavi SF, Sureda A, Moghaddam AH, Khanjani S, Xiao J, Shirooie S, Tsetegho Sokeng AJ, Baldi A, Mannina L, Nabavi SM, Daglia M Tags: Food Chem Toxicol Source Type: research
Magnesium sulfate protects blood –brain barrier integrity and reduces brain edema after acute ischemic stroke in rats
This study was designed to evaluate the effects of magnesium sulfate on vasogenic brain edema formation and blood –brain barrier (BBB) disruption caused by ischemia-reperfusion (IR) in a rat model of ischemic stroke. A total of 72 male Sprague-Dawley rats were categorized into the following three primary groups: sham, control ischemic, magnesium-sulfate-treated (300 mg/kg loading dose, followed by an additio nal 100 mg/kg) ischemic (n = 24 in each group). Transient focal cerebral ischemia was induced by 60-min-long occlusion of the left middle cerebral artery, followed by 24-h-long reperfusion. Sensorimotor deficit...
Source: Metabolic Brain Disease - April 28, 2019 Category: Neurology Source Type: research
