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Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - September 1, 2015 Category: Neuroscience Authors: Zhiwei Tang, Shiping Li, Pengcheng Han, Junxiang Yin, Yan Gan, Qingwei Liu, Jinkun Wang, Chongqian Wang, Yu Li, Jiong Shi Tags: Original Article Source Type: research

Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Ketamine improves neuronal recovery following spreading depolarization in peri ‐infarct tissues
We examined spreading depolarization (SD) waves in a mouse stroke model. SDs were initiated by focal potassium chloride application and propagated through a region of graded perfusion deficit created by distal middle cerebral artery (dMCA) occlusion. Longer lasting depolarizations (DC shifts measured from local field potential (LFP) electrodes) and neuronal Ca2+ transients (epifluorescence GCaMP imaging) occurred at locations with larger perfusion deficits (proximal to occlusion), as compared with remote recording sites (laser speckle contrast imaging (LSCI) of cerebral perfusion). Ketamine, at concentrations that did not ...
Source: Journal of Neurochemistry - August 19, 2023 Category: Neuroscience Authors: Katelyn M. Reinhart, Russell A. Morton, K. C. Brennan, Andrew P. Carlson, C. William Shuttleworth Tags: ORIGINAL ARTICLE Source Type: research

Levosimendan improves contractility in vivo and in vitro in a rodent model of post‐myocardial infarction heart failure
ConclusionIn HF animals LEV improved the contractility by increasing the Ca2+ sensitivity. Furthermore loading conditions were changed, and LEV could consequently change organ perfusion. An observed increase in diastolic Ca2+ following LEV treatment and clinical implications of this should be further addressed.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - February 5, 2014 Category: Physiology Authors: Solveig Moss Kolseth, Natale Pinheiro Lage Rolim, Øyvind Salvesen, Dag Ole Nordhaug, Alexander Wahba, Morten Andre Høydal Tags: Regular Paper Source Type: research

Relation of Diastolic Blood Pressure and Coronary Artery Calcium to Coronary Events and Outcomes (From the Multi-Ethnic Study of Atherosclerosis)
Diastolic blood pressure has a J-curve relationship with coronary heart disease and death. Because this association is thought to reflect reduced coronary perfusion at low diastolic blood pressure, we hypothesized that the J-curve would be most pronounced among persons with coronary artery calcium. Among 6,811 participants from the Multi-Ethnic Study of Atherosclerosis, we used Cox models to examine if diastolic blood pressure category is associated with coronary heart disease events, stroke, and mortality.
Source: The American Journal of Cardiology - August 8, 2017 Category: Cardiology Authors: Faisal Rahman, Mahmoud Al Rifai, Michael J. Blaha, Khurram Nasir, Matthew J Budoff, Bruce M. Psaty, Wendy S. Post, Roger S. Blumenthal, John W. McEvoy Source Type: research

Abstract 031: Diastolic Blood Pressure, Coronary Artery Calcium, and Cardiac Outcomes in the Multi-ethnic Study of Atherosclerosis Session Title: Cardiac Hypertrophy and Dysfunction
Diastolic blood pressure (BP) has a J-curve relationship with coronary heart disease and death. Because this association is thought to reflect reduced coronary perfusion at low diastolic BP, our objective was to test whether the J-curve is most pronounced among persons with coronary artery calcium. Among 6,811 participants from the Multi-Ethnic Study of Atherosclerosis, we used Cox models to examine if diastolic BP category is associated with coronary heart disease events, stroke, and mortality. Analyses were conducted in the sample overall and after stratification by coronary artery calcium score. In multivariable-adjuste...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: John W McEvoy, Faisal Rahman, Mahmoud Al Rifai, Michael Blaha, Khurram Nasir, Matthew Budoff, Bruce Psaty, Wendy Post, Roger Blumenthal Tags: Oral Abstract Presentations Source Type: research

Long-term optical imaging of neurovascular coupling in mouse cortex using GCaMP6f and intrinsic hemodynamic signals
Publication date: 15 January 2018 Source:NeuroImage, Volume 165 Author(s): Xiaochun Gu, Wei Chen, Jiang You, Alan P. Koretsky, N.D. Volkow, Yingtian Pan, Congwu Du Cerebral hemodynamics are modulated in response to changes in neuronal activity, a process termed neurovascular coupling (NVC), which can be disrupted by neuropsychiatric diseases (e.g., stroke, Alzheimer's disease). Thus, there is growing interest to image long-term NVC dynamics with high spatiotemporal resolutions. Here, by combining the use of a genetically-encoded calcium indicator with optical techniques, we develop a longitudinal multimodal optical imagin...
Source: NeuroImage - November 6, 2017 Category: Neuroscience Source Type: research

Postpartum Increases in Cerebral Edema and Inflammation in response to Placental Ischemia during Pregnancy
Publication date: Available online 26 March 2018 Source:Brain, Behavior, and Immunity Author(s): Ahsia M. Clayton, Qingmei Shao, Nina D. Paauw, Ashtin B. Giambrone, Joey P. Granger, Junie P. Warrington Reduced placental blood flow results in placental ischemia, an initiating event in the pathophysiology of preeclampsia, a hypertensive pregnancy disorder. While studies show increased mortality risk from Alzheimer’s disease, stroke, and cerebrovascular complications in women with a history of preeclampsia, the underlying mechanisms are unknown. During pregnancy, placental ischemia, induced by reducing uterine perfusion pr...
Source: Brain, Behavior, and Immunity - March 26, 2018 Category: Neurology Source Type: research

Postpartum Increases in Cerebral Edema and Inflammation in response to Placental Ischemia during Pregnancy.
Abstract Reduced placental blood flow results in placental ischemia, an initiating event in the pathophysiology of preeclampsia, a hypertensive pregnancy disorder. While studies show increased mortality risk from Alzheimer's disease, stroke, and cerebrovascular complications in women with a history of preeclampsia, the underlying mechanisms are unknown. During pregnancy, placental ischemia, induced by reducing uterine perfusion pressure (RUPP), leads to cerebral edema and increased blood-brain barrier (BBB) permeability; however whether these complications persist after delivery is not known. Therefore, we tested ...
Source: Brain, Behavior, and Immunity - March 24, 2018 Category: Neurology Authors: Clayton AM, Shao Q, Paauw ND, Giambrone AB, Granger JP, Warrington JP Tags: Brain Behav Immun Source Type: research

The role of calcium handling mechanisms in reperfusion injury.
Abstract Cardiovascular diseases, such as stroke and myocardial infarction (MI) remain the major cause of death and disability worldwide. However, the mortality of MI has declined dramatically over the past several decades because of advances in medicines (thrombolytic agents, antiplatelet drugs, beta blockers, and angiotensin converting enzyme inhibitors) and approaches to restore tissue perfusion(percutaneous coronary intervention and cardiopulmonary bypass). Animals studies have been shown that these treatments have been effective in reducing acute myocardial ischemic injury and limiting MI size. The paradox is...
Source: Current Pharmaceutical Design - November 20, 2018 Category: Drugs & Pharmacology Authors: Pittas K, Vrachatis DA, Angelidis C, Tsoucala S, Giannopoulos G, Defteros S Tags: Curr Pharm Des Source Type: research

Association between vascular calcification in intracranial vertebrobasilar circulation and luminal stenosis
ConclusionOur study showed a moderate correlation between higher burden of vascular calcification and the degree of luminal stenosis. However, higher calcium burden and circumferential wall calcification were not associated with severe luminal stenosis.
Source: Neuroradiology - May 12, 2022 Category: Radiology Source Type: research

Acetate suppresses myocardial contraction via the short-chain fatty acid receptor GPR43
The heart has high energy requirements, with an estimated 40%–60% of myocardial ATP production derived from the oxidation of fatty acids under physiological conditions. However, the effect of short-chain fatty acids on myocardial contraction remains controversial, warranting further research. The present study sought to investigate the effects and mechanisms of acetate, a short-chain fatty acid, on myocardial contraction in rat ventricular myocytes. Echocardiography and Langendorff heart perfusion were used to evaluate cardiac function. Cell shortening and calcium transient were measured in isolated cardiomyocytes. The p...
Source: Frontiers in Physiology - December 16, 2022 Category: Physiology Source Type: research

Role of TRPV1 in electroacupuncture-mediated signal to the primary sensory cortex during regulation of the swallowing function
CONCLUSION: The TRPV1 at CV23 after EA treatment might play a key role in mediating local blood perfusion but was not involved in transferring EA signals to the central nervous system (CNS). These findings collectively suggested that TRPV1 may be one of the important regulators involved in the mechanism of EA treatment for improving swallowing function in PSD.PMID:37718934 | DOI:10.1111/cns.14457
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Si Yuan Bo Qiu Ying Liang Bing Deng Jing Xu Xiaorong Tang Junshang Wu Sheng Zhou Zeli Li Hongzhu Li Qiuping Ye Lin Wang Shuai Cui Chunzhi Tang Wei Yi Lulu Yao Nenggui Xu Source Type: research

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