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Specialty: Psychiatry
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Total 154 results found since Jan 2013.

Psychosis Polyrisk Score (PPS) for the Detection of Individuals At-Risk and the Prediction of Their Outcomes
Conclusions The combination of risk/protective factors encompassing genetic (PRS) and non-genetic information (PPS) holds promise for overcoming the epidemiological weakness of the CHR-P paradigm. The PPS conceptually and empirically developed here will facilitate future research in this field and hopefully advance our ability to detect individuals at-risk for psychosis and forecast their clinical outcomes. Ethics Statement This study was supported by the King's College London Confidence in Concept award from the Medical Research Council (MRC) (MC_PC_16048) to PF-P. This study also represents independent researc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Blood amyloid levels and risk of dementia in the Ginkgo Evaluation of Memory Study (GEMS): A longitudinal analysis.
We examined baseline plasma β-amyloid (Aβ) levels in relationship to incident dementia during a period of 8.5 years in 2840 subjects age >75 years; 2381 were cognitively normal (CN) and 450 mild cognitive impairment. RESULTS: Increased plasma Aβ1-40 and Aβ1-42 levels were associated with gender (women), age, low education, creatinine levels, history of stroke, and hypertension. CN participants who developed dementia had lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio compared with those who did not. Aβ levels did not predict dementia in mild cognitive impairment participants. DISCUSSION: There was an inv...
Source: The Journal of Alzheimers Association - July 2, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Associations of Race-Ethnicity and History of Traumatic Brain Injury With Age at Onset of Alzheimer's Disease.
CONCLUSIONS: A history of TBI with LOC was associated with AD onset 2-3 years earlier in non-Hispanic Caucasians and African Americans and an onset nearly 6 years earlier in Hispanic females; no association was observed in Hispanic males. Further work in underserved populations is needed to understand possible underlying mechanisms for these differences. PMID: 31619118 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 19, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

This Under-Utilized Drug Is Actually Critical for Treatment-Resistant Depression
Many people with clinical depression have tried an array of medication and still feel sick. Maybe they’ve tried different selective serotonin reuptake inhibitors (SSRIs) or selective norepinephrine reuptake inhibitors (SNRIs). Maybe they’ve taken these antidepressants along with an antipsychotic (a common strategy to boost effectiveness). Either way, the lack of improvement can make individuals feel even more hopeless and fear the darkness will never lift. If this sounds all-too familiar, you’re definitely not alone. In fact, up to 30 percent of people with depression don’t respond to the first few antidepressants ...
Source: Psych Central - November 27, 2019 Category: Psychiatry Authors: Margarita Tartakovsky, M.S. Tags: Antidepressants Depression Disorders ECT General Medications Treatment Atypical Depression difficult to treat depression Managing Depression MAOIs medication for depression Monoamine Oxidase Inhibitors Severe Depression Treatin Source Type: news

Gospel Music: A Catalyst for Retention, Engagement, and Positive Health Outcomes for African Americans in a Cardiovascular Prevention and Treatment Program.
Conclusions: The addition of a gospel music program as a catalyst for increase engagement in a sustainable, healthy lifestyle program warrants further consideration and additional study in African American churches. PMID: 32277749 [PubMed - as supplied by publisher]
Source: Advances in Mind Body Medicine - April 12, 2020 Category: Psychiatry Tags: Adv Mind Body Med Source Type: research

Personality disorders and cause-specific mortality: a nationwide study of 2 million adolescents.
CONCLUSIONS: Personality disorder in late adolescence is associated with increased risk of cardiovascular, external- and all-cause mortality. Increased cardiovascular mortality is evident before the age of 40 years and may point to the importance of lifestyle education already in youth. PMID: 33050953 [PubMed - as supplied by publisher]
Source: Psychological Medicine - October 14, 2020 Category: Psychiatry Authors: Tiosano S, Laur L, Tirosh A, Furer A, Afek A, Fink N, Derazne E, Tzur D, Fruchter E, Ben-Yehuda A, Bader T, Amital H, Szklo M, Weiser M, Twig G Tags: Psychol Med Source Type: research

Does Low Subjective Social Status Predict Cognitive Decline in Chinese Older Adults? A 4-Year Longitudinal Study From Hong Kong.
CONCLUSION: Cognitive decline is influenced by self-perceived rank in proximal reference groups rather than socioeconomic comparison with society at-large. SSS-Community is a useful, single-item supplementary instrument to improve prediction of cognitive decline in elderly Chinese. PMID: 33563520 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - February 12, 2021 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Book-Oriented Environment in Childhood and Current Cognitive Performance among Old-Aged Europeans
CONCLUSIONS: These findings suggest that early-life book-oriented environment may be important in shaping cognitive aging.PMID:34515091 | DOI:10.1159/000518129
Source: Dementia and Geriatric Cognitive Disorders - September 13, 2021 Category: Psychiatry Authors: Galit Weinstein Ella Cohn-Schwartz Noam Damri Source Type: research

The plasticity of late-onset dementia: A nationwide cohort study in Denmark
DISCUSSION: Most of the observed plasticity in late-onset dementia is associated with a risk decline across successive birth cohorts that is independent of improvements in traditional risk factors.PMID:34569688 | DOI:10.1002/alz.12469
Source: The Journal of Alzheimers Association - September 27, 2021 Category: Psychiatry Authors: Emilie R Hegelund Amar J Mehta Laust H Mortensen Rudi G J Westendorp Source Type: research

Is There an Association between Norton Scale and Cognitive Impairment in Hip Fractured Elderly Patients?
CONCLUSION: Our findings suggest that there is an association between Norton Scale Scores and cognitive impairment. Norton score parameters, under certain circumstances, such as speech and other communication difficulties, can be used as a proxy measure for MMSE to indicate cognitive impairment. These findings can be even more helpful in the present time of "COVID-19," when we have to evaluate older patients with facial masks and other defensive suits.PMID:34915501 | DOI:10.1159/000520852
Source: Dementia and Geriatric Cognitive Disorders - December 16, 2021 Category: Psychiatry Authors: Nadya Kagansky Ilia Stambler Eliyahu Hayim Mizrahi Source Type: research

The assessment of cognitive function in the German National Cohort (NAKO) - Associations of demographics and psychiatric symptoms with cognitive test performance
CONCLUSIONS: The NAKO cognitive test battery and the derived cognitive domain scores for memory and executive function are sensitive measures of cognition.PMID:35175181 | DOI:10.1080/15622975.2021.2011408
Source: The World Journal of Biological Psychiatry - February 17, 2022 Category: Psychiatry Authors: Luca Kleineidam Melina Stark Steffi G Riedel-Heller Alexander Pabst Florian Schmiedek Fabian Streit Marcella Rietschel Johanna Klinger-K önig Hans J Grabe Angelika Erhardt G ötz Gelbrich B örge Schmidt NAKO Investigators Klaus Berger Michael Wagner Source Type: research