Filtered By:
Drug: Estradiol
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 6435 results found since Jan 2013.
Effects of maternal exposure to Di-n-butyl phthalate during pregnancy and breastfeeding on ovarian development and function of F1 female rats
This study aimed to investigate the effects of maternal exposure to Di-n-butyl phthalate (DBP) during pregnancy and breastfeeding on F1 ovarian development and function. A rat model of maternal exposure to DBP during pregnancy and breastfeeding was established by gavage feeding female Sprague Dawley rats with 0, 10, 100, or 600mg/kg/day DBP from gestational day (GD) 12 to postnatal day (PND) 21. F1 offspring were weaned on PND21 and were not exposed to DBP afterward. The age of vaginal opening and estrus onset, estrous cyclicity, c-Kit-ligand expression on ovarian granulosa cells, and the weight of ovaries and uterus of F1...
Source: Environmental Toxicology and Pharmacology - February 14, 2016 Category: Environmental Health Source Type: research
Short-Term and Long-Term Effects of Bisphenol A (BPA) Exposure During Breastfeeding on the Biochemical and Endocrine Profiles in Rats
Horm Metab Res 2018; 50: 491-503 DOI: 10.1055/a-0628-6708Neonates can be exposed to bisphenol A (BPA) through placenta and milk, and BPA is associated with disorders such as precocious puberty and obesity. We evaluated the effects of BPA exposure during breastfeeding on the biochemical and endocrine profiles in young and adult rat progeny. From postnatal day (PND) 3 to 15 dams were divided into low-dose BPA treatment [50 μg/kg/day s.c. (BPA-LD)], high-dose BPA treatment [5 mg/kg/day s.c. (BPA-HD)], and Control (vehicle) groups. Milk was collected at PND15 and 21, which represents the end of exposure and 6 days after w...
Source: Hormone and Metabolic Research - June 8, 2018 Category: Endocrinology Authors: Santos-Silva, Ana P. de Moura, Egberto Gaspar Pinheiro, Cintia R. Oliveira, Elaine Lisboa, Patricia Cristina Tags: Endocrine Research Source Type: research
Individual differences in risk taking and endogeneous levels of testosterone, estradiol, and cortisol: A systematic literature search and three independent meta-analyses
Publication date: Available online 3 May 2018 Source:Neuroscience & Biobehavioral Reviews Author(s): Jennifer Kurath, Rui Mata Hormonal levels have been hypothesized to serve as proximal biological mechanisms underlying individual differences in risk taking. We conducted a systematic literature search and independent meta-analyses to assess the link between endogenous testosterone, estradiol, and cortisol levels and risk-taking related constructs (i.e., risk-taking propensity, impulsivity, sensation seeking, novelty seeking). We found small correlations between risk-taking constructs and testosterone (r = 0.12...
Source: Neuroscience and Biobehavioral Reviews - May 3, 2018 Category: Neuroscience Source Type: research
De novo transcriptome analysis to search for sex-differentiation genes in the Siberian sturgeon.
Abstract
The sturgeon family includes many species that are lucrative for commercial caviar production, some of which face critical conservation problems. The purpose of this study was to identify genes involved in gonadal sex differentiation in sturgeons, contributing to our understanding of the biological cycle of this valuable species. A high-quality de novo Siberian sturgeon gonadal transcriptome was built for this study using gonadal samples from undifferentiated fish at 3, 5, and 6 months of age; recently sex-differentiated fish at 9 months of age; and immature males and females at 14-17 months of age. Undif...
Source: General and Comparative Endocrinology - August 3, 2018 Category: Endocrinology Authors: Vizziano-Cantonnet D, Lasalle A, Di Landro S, Klopp C, Genthon C Tags: Gen Comp Endocrinol Source Type: research
In search of neuroprotective therapies based on the mechanisms of estrogens.
Authors: DonCarlos LL, Azcoitia I, Garcia-Segura LM
Abstract
Although estradiol is a neuroprotective factor, estrogen therapy in older women increases the risk of adverse cognitive outcomes and poses additional peripheral risks, requiring careful use of estrogenic compounds as treatments for neurodegenerative conditions or neural injury. Potential alternatives to estrogen therapy to promote neuroprotection might include treatment with molecules that are able to interact with estrogen receptors, with alternative mechanisms of action, or with molecules that induce local estradiol synthesis in the brain, or a combinat...
Source: Expert Review of Endocrinology and Metabolism - February 15, 2019 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan
Conclusion
Autoimmune disease states show strong associations with endocrinological changes in human and animal studies. There is clear evidence for the role of sex steroids in the immune disturbances that result in autoimmune diseases (Figure 2). The majority of women who pass through the different endocrinological transition states do not succumb to autoimmune diseases.
FIGURE 2
Figure 2. Factors that contribute to increased incidence and prevalence of autoimmunity in women. In women (46XX) with genetic susceptibility to autoimmune states, external environmental stimuli affect modifying factors as well as endo...
Source: Frontiers in Endocrinology - April 28, 2019 Category: Endocrinology Source Type: research
A Case –Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations
Conclusions:
Our results suggest that maternal exposure to BDE-99, -100, and -154 may be associated with abnormal migration of testes in the male fetus. This may be due to the anti-androgenic properties of the PBDEs. https://doi.org/10.1289/EHP522
Received: 17 May 2016
Revised: 22 September 2016
Accepted: 08 October 2016
Published: 26 May 2017
Address correspondence to C.G. Goodyer, Research Institute of McGill University Health Centre, Centre for Translational Biology, EM0.3211, 1001 Decarie Blvd., Montreal, QC, Canada H4A 3J1. Telephone: (514) 934-1934, ext. 22481. E-mail: cindy.goodyer@muhc.mcgill.ca
Supplemental Mat...
Source: EHP Research - May 27, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research
Cabergoline: a review of its use in the inhibition of lactation for women living with HIV.
CONCLUSIONS: Cabergoline is a safe and effective pharmacologic option for the prevention of physiological lactation and associated physical symptoms in non-breastfeeding women. Future studies should focus on its safety, efficacy and acceptability among WLWH.
PMID: 31183987 [PubMed - in process]
Source: Journal of the International AIDS Society - June 13, 2019 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Associations Between Sex Hormone Levels and Autistic Traits in Infertile Patients With Polycystic Ovary Syndrome and Their Offspring
ConclusionCompared with the control group, PCOS patients had more autistic traits (especially social dysfunction). The autistic traits in PCOS patients might be related to the elevation in testosterone concentration and luteinizing hormone levels and the decline in progesterone level. Moreover, the autistic traits in the offspring of PCOS patients might be related to the parental high delivery age and high tendency to autism traits.
Source: Frontiers in Endocrinology - January 31, 2022 Category: Endocrinology Source Type: research
Motivational increase of androgens and behavior by infant distress calls in highly responsive common marmoset fathers, Callithrix jacchus
Horm Behav. 2022 Mar 30;142:105162. doi: 10.1016/j.yhbeh.2022.105162. Online ahead of print.ABSTRACTCommon marmoset fathers are highly involved in care of their infants. However, variability exists in their response to infant behavior even in paternally experienced fathers. Using infant distress cries as a motivation test, we investigated: 1. the differences in paternally experienced fathers' motivation to search for the infant vocalization stimuli; 2. the relationship between a father's motivation to search for the source of the infant cries and testosterone levels; and 3. if there is a rapid steroidogenesis pathway leadi...
Source: Hormones and Behavior - April 2, 2022 Category: Endocrinology Authors: Natalie J Dukes Hayley Ash Gabriela de Faria Oliveira Megan E Sosa Robinson W Goy Ricki J Colman Toni E Ziegler Source Type: research
Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review
CONCLUSION: In conclusion, vitamin E isoforms, isolated or associated, showed antitumor and chemopreventive activity. However, due to studies heterogeneity, there is a need for further analysis to establish dose, form, supplementation time and breast cancer stage.PMID:36657931 | DOI:10.1016/j.clnesp.2022.11.001
Source: Clinical Breast Cancer - January 19, 2023 Category: Cancer & Oncology Authors: Maria do Perpetuo Socorro de Sousa Coelho Irislene Costa Pereira Kynnara Gabriella Feitosa de Oliveira Iara Katryne Fonseca Oliveira M árcia Dos Santos Rizzo Victor Alves de Oliveira Felipe Cavalcanti Carneiro da Silva Francisco Leonardo Torres-Leal Jo à Source Type: research
Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception
CONCLUSIONS: There are no comparative studies assessing risk of thromboembolism in COVID-19 patients who use hormonal contraception, which was the primary objective of this review. Very little evidence exists examining the risk of increased COVID-19 disease severity for combined hormonal contraception users compared to non-users of hormonal contraception, and the evidence that does exist is of very low certainty. The odds of hospitalization for COVID-19 positive users of combined hormonal contraceptives may be slightly decreased compared with those of hormonal contraceptive non-users, but the evidence is very uncertain as ...
Source: Cochrane Database of Systematic Reviews - January 9, 2023 Category: General Medicine Authors: Megan A Cohen Alison Edelman Robin Paynter Jillian T Henderson Source Type: research
