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Drug: Lidoderm

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Total 65 results found since Jan 2013.

Spasticity-induced Pectoralis minor syndrome: a case-report.
Conclusion: It should be kept in mind that spasticity in the upper extremity may develop in the pectoralis minor muscle, and may cause pressure on the neurovascular structures. Ultrasound-guided botulinum toxin injections can be a safe and effective treatment for PMS in a patent with post stroke spastic hemiparesis. PMID: 31774031 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - November 26, 2019 Category: Neurology Authors: Aktas I, Kaya E, Akpinar P, Atici A, Unlu Ozkan F, Palamar D, Akgun K Tags: Top Stroke Rehabil Source Type: research

Unsedated Outpatient Percutaneous Endoscopic Gastrostomy in Stroke Patients: Is It Feasible and Safe?
This study sought to determine the feasibility and safety of outpatient, unsedated PEG implementation in stroke patients. This retrospective cohort study involved stroke victims who underwent unsedated outpatient PEG insertion from 2014 to 2017 at our Surgical Endoscopy Unit. Patients were given pharyngeal anesthesia with lidocaine 10% spray, while the PEG tube was placed under local anesthesia. The incidence of intraprocedural and postprocedural complications and 30-day mortality rate were recorded. Data from 127 cases were analyzed. The procedures were performed with minor, transient complications, which resolved after r...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Cerebral Air Embolism after Esophagogastroduodenoscopy: Insight on Pathophysiology, Epidemiology, Prevention and Treatment
Air embolism is an extremely rare complication that can follow gastrointestinal endoscopy. The most accepted treatment of cerebral air embolism (CAE) is hyperbaric oxygen (HBO). Limited evidence suggests that lidocaine may have a neuroprotective effect. The exact mechanism does not appear to be well elucidated.
Source: Journal of Stroke and Cerebrovascular Diseases - September 25, 2019 Category: Neurology Authors: Malik Ghannam, Azizullah Beran, Dana Ghazaleh, Tanner Ferderer, Brent Berry, Mona Al Banna, Leighton Mohl, Christopher Streib, Tapan Thacker, Ivan Matos Source Type: research

The myofascial component of the pain in the painful shoulder of the hemiplegic patient
CONCLUSION: Trigger point blockade with lidocaine can reduce pain perception in spastic hemiplegic shoulder in as much as 50% of stroke survivors for four months.
Source: Clinics - April 30, 2019 Category: General Medicine Source Type: research

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Not Just Acid Reflux: The Need to Think Worst First
Discussion Heart disease is the leading cause of death in the United States.1 This year, 720,000 Americans will have a new coronary event—defined as first hospitalized myocardial infarction (MI) or coronary heart disease death—and around 335,000 will have a recurrent event. Approximately 35% of people who experience a coronary event in a given year and around 14% of patients who have an acute coronary syndrome will die from it.1 Roughly 60% of patients with an acute coronary syndrome are transported to the emergency department via ambulance.2–4. Up to one-third of patients experiencing an MI may not complain of chest...
Source: JEMS Special Topics - January 13, 2019 Category: Emergency Medicine Authors: Stephen Sanko, MD, FACEP Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study
Central poststroke pain (CPSP) is a neuropathic pain disorder, the underlying mechanisms of which are not well understood. It has been suggested that stroke-associated loss of inhibitory neurons in the spinothalamic tract causes disinhibition of thalamic neurons, which autonomously generate ectopic nociceptive action potentials responsible for the pain experience. We hypothesized that CPSP is a result of misinterpretation of afferent sensory input by the sensitized neurons within the brain, rather than generated spontaneously by the damaged central nervous system (CNS) neurons. To test this hypothesis, we prospectively rec...
Source: Pain - June 26, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

A meta-analysis of pharmacological neuroprotection in noncardiac surgery: focus on statins, lidocaine, ketamine, and magnesium sulfate.
CONCLUSIONS: The available clinical data are still scarce. Our analyses indicate no protective effects by statins against perioperative stroke but some favorable trends toward delayed stroke. Further randomized trials are needed to unequivocally assess the neuroprotective potential of current pharmacological agents in non-cardiac surgery. PMID: 29630129 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 10, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Effect of different analgesic techniques on hemodynamic variables recorded with an esophageal Doppler monitor during ovariohysterectomy in dogs.
This study compared the efficacy of intravenous (IV) fentanyl and ketamine with lumbosacral epidural lidocaine in dogs undergoing ovariohysterectomy. Dogs with esophageal Doppler monitoring (n = 112) were included in this retrospective study. All dogs were premedicated with dexmedetomidine and methadone, induced with IV propofol or alfaxalone and maintained using isoflurane and IV fentanyl, IV ketamine, or epidural lidocaine. Heart rate (HR), mean arterial pressure (MAP), expired fraction of isoflurane (ETIso), stroke distance (SD), minute distance (MD), peak velocity (PV) and mean acceleration (MA) were recorded before an...
Source: The Canadian Veterinary Journal - April 1, 2018 Category: Veterinary Research Authors: Sández I, Soto M, Torralbo D, Rioja E Tags: Can Vet J Source Type: research

A combination of levobupivacaine and lidocaine for paravertebral block in breast cancer patients undergoing quadrantectomy causes greater hemodynamic oscillations than levobupivacaine alone.
CONCLUSION: The use of 0.5% levobupivacaine in comparison with 0.5% levobupivacaine with 2% lidocaine solution for PVB had a longer time-to-block onset, but it also reduced hemodynamic disturbances and prolonged the analgesic effect. PMID: 28857520 [PubMed - in process]
Source: Croatian Medical Journal - August 31, 2017 Category: General Medicine Authors: Župčić M, Graf Župčić S, Duzel V, Šimurina T, Šakić L, Fudurić J, Peršec J, Milošević M, Stanec Z, Korušić A, Barišin S Tags: Croat Med J Source Type: research

Influence of the thoracic epidural anesthesia on the left ventricular function: an echocardiographic study.
CONCLUSIONS: The net effect of TEA in awake patients is a reduction of HR and LV systolic function, which results in a reduction of the CO and the MAP. The effect of TEA on LV diastolic function remains to be addressed by larger studies. PMID: 28094481 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - January 19, 2017 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Transient deficits after inadvertent intrathecal trigger-point injection with lidocaine
A 43-year-old woman had trigger-point injections for chronic neck pain by a traditional Chinese medicine physician. Paravertebral muscles at C5-C6 were infiltrated with lidocaine. Thirty minutes later, right-sided hemiparesis with nystagmus, dysarthria, and anisocoria developed. The patient complained of vertigo, vomited multiple times, and became somnolent. Neuroimaging revealed air in the ventricular system (figure 1) and in the dural sheath of the fifth cervical nerve root (figure 2), implying an accidental intrathecal injection and thus a possible direct effect of lidocaine. Three hours later, neurologic symptoms resol...
Source: Neurology - August 21, 2016 Category: Neurology Authors: Bereczki, D., Peto, N., Szegedi, N. Tags: All Cerebrovascular disease/Stroke, All Pain, Cerebrospinal Fluid NEUROIMAGES Source Type: research

Functional characterization of a mouse model for central post-stroke pain
Conclusions These results suggest that the evoked hypersensitivity observed in central post-stroke pain is causally linked to on-going neuronal activity in the lateral thalamus.
Source: Molecular Pain - March 7, 2016 Category: Molecular Biology Authors: Gritsch, S., Bali, K. K., Kuner, R., Vardeh, D. Tags: Original Article Source Type: research

Lidocaine response rate in aEEG‐confirmed neonatal seizures: Retrospective study of 413 full‐term and preterm infants
Summary ObjectiveTo investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second‐ or third‐line antiepileptic drug (AED) for neonatal seizures. MethodsFull‐term (n = 319) and preterm (n = 94) infants, who received lidocaine for neonatal seizures confirmed on amplitude‐integrated EEG (aEEG), were studied retrospectively (January 1992–December 2012). Based on aEEG findings, the response was defined as good (>4 h no seizures, no need for rescue medication); intermediate (0–2 h no seizures, but rescue medication needed after 2–4 h); or no clear response (resc...
Source: Epilepsia - December 31, 2015 Category: Neurology Authors: Lauren C. Weeke, Mona C. Toet, Linda G. M. Rooij, Floris Groenendaal, Geraldine B. Boylan, Ronit M. Pressler, Lena Hellström‐Westas, Marcel P. H. Broek, Linda S. Vries Tags: Full ‐Length Original Research Source Type: research

Neuroprotection After Major Cardiovascular Surgery
Opinion statement Neurologic injury is a common complication of major cardiovascular procedures including coronary artery bypass graft (CABG) surgery, coronary valve replacement, and aortic aneurysm surgery. However, despite ongoing research in the field of neuroprotection, there are currently few pharmacologic and interventional options to effectively protect the brain and spinal cord in the postoperative period. CSF drainage after aortic surgery currently stands as the only neuroprotective intervention that has been consistently shown to protect the spinal cord from ischemic injury, leading to significantly few...
Source: Current Treatment Options in Neurology - May 15, 2015 Category: Neurology Source Type: research