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Drug: Acetylcysteine
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Total 28 results found since Jan 2013.

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Protective Effects of Brain Infarction by N-Acetylcysteine Derivatives Basic Sciences
Conclusions—The results indicate that detoxification of acrolein by NAC derivatives is caused through glutathione conjugation with acrolein catalyzed by glutathione S-transferases, which can be stabilized by NAC derivatives. This is a new concept of acrolein detoxification by NAC derivatives.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Takeshi Uemura, Kenta Watanabe, Kenta Ko, Kyohei Higashi, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama, Koichi Takao, Yoshiaki Sugita, Akihiko Sakamoto, Yusuke Terui, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi Tags: Animal Models of Human Disease, Ischemia, Oxidant Stress, Ischemic Stroke Original Contributions Source Type: research

Oral N-acetylcysteine and exercise tolerance in mild chronic obstructive pulmonary disease
In conclusion, modulation of plasma redox status with oral NAC treatment was not translated into beneficial effects on central or peripheral components of the oxygen transport pathway, thereby failing to improve exercise tolerance in nonhypoxemic patients with mild COPD. NEW & NOTEWORTHY Acute antioxidant treatment with N-acetylcysteine (NAC) elevated plasma glutathione but did not modulate central or peripheral components of the O2 transport pathway, thereby failing to improve exercise tolerance in patients with mild chronic obstructive pulmonary disease (COPD).
Source: Journal of Applied Physiology - May 18, 2017 Category: Physiology Authors: Hirai, D. M., Jones, J. H., Zelt, J. T., da Silva, M. L., Bentley, R. F., Edgett, B. A., Gurd, B. J., Tschakovsky, M. E., ODonnell, D. E., Neder, J. A. Tags: RESEARCH ARTICLE Source Type: research

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi.
Conclusions -We provide evidence that NAC is an effective and safe alternative to currently available antithrombotic agents to restore vessel patency after arterial occlusion. PMID: 28487393 [PubMed - as supplied by publisher]
Source: Circulation - May 9, 2017 Category: Cardiology Authors: Martinez de Lizarrondo S, Gakuba C, Herbig BA, Repessé Y, Ali C, Denis CV, Lenting P, Touzé E, Diamond SL, Vivien D, Gauberti M Tags: Circulation Source Type: research

The effect of ethyl pyruvate and N-acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic stroke
Reperfusion therapies play an important role in early-period treatment for patients presenting to the emergency department due to stroke. However, the ischemia-reperfusion injury that may occur with reperfusion must then be considered. The purpose of this study was to determine the effectiveness of N-acetylcysteine (NAC) and ethyl pyruvate in preventing ischemia-reperfusion injury.
Source: The American Journal of Emergency Medicine - June 4, 2016 Category: Emergency Medicine Authors: Suha Turkmen, Ozgen Cekic Gonenc, Yunus Karaca, Ahmet Mentese, Selim Demir, Ercument Beyhun, Aynur Sahin, Abdulkadir Gunduz, Esin Yulug, Suleyman Turedi Source Type: research

The Effect of Ethyl Pyruvate and N-Acetylcysteine on Ischemia Reperfusion Injury in an Experimental Model of Ischemic Stroke
Reperfusion therapies play an important role in early-period treatment of patients presenting to the emergency department due to stroke. However, the ischemia–reperfusion injury that may occur with reperfusion must then be considered. The purpose of this study was to determine the effectiveness of N-acetylcysteine (NAC) and ethyl pyruvate in preventing ischemia–reperfusion injury.
Source: The American Journal of Emergency Medicine - June 4, 2016 Category: Emergency Medicine Authors: Turkmen Suha, Cekic Gonenc Ozgen, Karaca Yunus, Mentese Ahmet, Demir Selim, Beyhun Ercument, Sahin Aynur, Gunduz Abdulkadir, Yulug Esin, Turedi Suleyman Source Type: research

Different effects of arginine vasopressin on high ‐mobility group box 1 expression in astrocytes isolated from stroke‐prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
Summary Stroke‐prone spontaneously hypertensive rats (SHRSP/Izm) develop severe hypertension and astrocytic oedema following ischaemic stimulation. During ischaemic stress high‐mobility group box 1 (Hmgb1) expression in astrocytes is induced, and subsequently potentiates deterioration of the brain due to ischaemic injury, which manifests as both cerebral inflammation and astrocytic oedema. Arginine vasopressin (AVP) induces brain injury and increases astrocytic swelling. After stroke, Hmgb1 and peroxiredoxin (Prx) are released at different times and activate macrophages in the brain via Toll‐like receptors (Tlr2s). T...
Source: International Journal of Experimental Pathology - April 28, 2016 Category: Pathology Authors: Kazuo Yamagata, Natumi Sone, Sari Suguyama, Toru Nabika Tags: Original Article Source Type: research

Different effects of arginine vasopressin on high‐mobility group box 1 expression in astrocytes isolated from stroke‐prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
Summary Stroke‐prone spontaneously hypertensive rats (SHRSP/Izm) develop severe hypertension and astrocytic oedema following ischaemic stimulation. During ischaemic stress high‐mobility group box 1 (Hmgb1) expression in astrocytes is induced, and subsequently potentiates deterioration of the brain due to ischaemic injury, which manifests as both cerebral inflammation and astrocytic oedema. Arginine vasopressin (AVP) induces brain injury and increases astrocytic swelling. After stroke, Hmgb1 and peroxiredoxin (Prx) are released at different times and activate macrophages in the brain via Toll‐like receptors (Tlr2s). T...
Source: International Journal of Experimental Pathology - April 28, 2016 Category: Pathology Authors: Kazuo Yamagata, Natumi Sone, Sari Suguyama, Toru Nabika Tags: Original Article Source Type: research

Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons
In conclusion, these results suggest that TEMPO ensures excellent ROS/RNS clearance and stress-signaling inhibition, thus effectively rescuing neurons from ROS/H2O2 plus NO/SNAP-induced insult. This study reveals a potential strategy for nitroxide antioxidants as a therapeutic agent against oxidative/nitrosative neurotoxicity.
Source: Nitric Oxide - February 16, 2016 Category: Chemistry Source Type: research

Circulating tumour necrosis factor receptors 1 and 2 predict contrast‐induced nephropathy and progressive renal dysfunction: A prospective cohort study
ConclusionMarkedly elevated concentrations of circulating TNFRs were correlated with the occurrence of CIN and significantly associated with prolonged renal dysfunction regardless of the development of CIN.
Source: Nephrology - July 21, 2015 Category: Urology & Nephrology Authors: Jung Nam An, Kyung Don Yoo, Jin Ho Hwang, Hack‐Lyoung Kim, Sang‐Hyun Kim, Seung Hee Yang, Jin Hyuk Kim, Dong Ki Kim, Yun Kyu Oh, Yon Su Kim, Chun Soo Lim, Jung Pyo Lee Tags: Original Article Source Type: research

Circulating tumor necrosis factor receptors 1 and 2 predict contrast‐induced nephropathy and progressive renal dysfunction: a prospective cohort study
ConclusionMarkedly elevated concentrations of circulating TNFRs were correlated with the occurrence of CIN and significantly associated with prolonged renal dysfunction regardless of the development of CIN.
Source: Nephrology - March 1, 2015 Category: Urology & Nephrology Authors: Jung Nam An, Kyung Don Yoo, Jin Ho Hwang, Hack‐Lyoung Kim, Sang‐Hyun Kim, Seung Hee Yang, Jin Hyuk Kim, Dong Ki Kim, Yun Kyu Oh, Yon Su Kim, Chun Soo Lim, Jung Pyo Lee Tags: Original Article Source Type: research

Glutamate transporters in brain ischemia: to modulate or not?
Abstract In this review, we briefly describe glutamate (Glu) metabolism and its specific transports and receptors in the central nervous system (CNS). Thereafter, we focus on excitatory amino acid transporters, cystine/glutamate antiporters (system xc-) and vesicular glutamate transporters, specifically addressing their location and roles in CNS and the molecular mechanisms underlying the regulation of Glu transporters. We provide evidence from in vitro or in vivo studies concerning alterations in Glu transporter expression in response to hypoxia or ischemia, including limited human data that supports the role of ...
Source: Acta Pharmacologica Sinica - March 31, 2014 Category: Drugs & Pharmacology Authors: Krzyżanowska W, Pomierny B, Filip M, Pera J Tags: Acta Pharmacol Sin Source Type: research