Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons

In conclusion, these results suggest that TEMPO ensures excellent ROS/RNS clearance and stress-signaling inhibition, thus effectively rescuing neurons from ROS/H2O2 plus NO/SNAP-induced insult. This study reveals a potential strategy for nitroxide antioxidants as a therapeutic agent against oxidative/nitrosative neurotoxicity.
Source: Nitric Oxide - Category: Chemistry Source Type: research