Oral N-acetylcysteine and exercise tolerance in mild chronic obstructive pulmonary disease

In conclusion, modulation of plasma redox status with oral NAC treatment was not translated into beneficial effects on central or peripheral components of the oxygen transport pathway, thereby failing to improve exercise tolerance in nonhypoxemic patients with mild COPD.
NEW & NOTEWORTHY Acute antioxidant treatment with N-acetylcysteine (NAC) elevated plasma glutathione but did not modulate central or peripheral components of the O2 transport pathway, thereby failing to improve exercise tolerance in patients with mild chronic obstructive pulmonary disease (COPD).

Source: Journal of Applied Physiology - May 18, 2017 Category: Physiology Authors: Hirai, D. M., Jones, J. H., Zelt, J. T., da Silva, M. L., Bentley, R. F., Edgett, B. A., Gurd, B. J., Tschakovsky, M. E., ODonnell, D. E., Neder, J. A. Tags: RESEARCH ARTICLE Source Type: research