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Heat Stroke Isn ’t Just a Short-Term Danger
With each summer of increased extreme heat, more people worldwide face the risks associated with heat exposure. Last year, Europe saw a record number of heat-related deaths, and even regions more used to dealing with hot weather, like South Asia, are seeing high temperatures start earlier and earlier in the season. Heat stroke—the most dangerous form of heat-related illness—is a growing threat and creates a public health quandary since there’s still no available treatment other than simply cooling victims down. What’s more, early research seems to suggest heat stroke could lead to further health con...
Source: TIME: Health - July 12, 2023 Category: Consumer Health News Authors: Haley Weiss Tags: Uncategorized climate change healthscienceclimate Source Type: news

Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration
Conclusion The developed and validated method to quantify neurounina-1 in beagle dog plasma using LC-MS/MS presented sensitivity and selectivity, thus allowing the rapid and precise determination of the pharmacokinetics of this neuroprotective compound working in the low nanomolar range. Ethics Statement This study was carried out in accordance with the recommendations of the general ethical guidelines established by the Brazilian Society for Laboratory Animal Science (SBCAL). The protocol was approved by the Committee for Ethics in Animal Use – State University of Campinas (CEUA/UNICAMP, protocol n° 3340-...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Sarah T Pendlebury, Peter M Rothwell, Oxford Vascular StudySummaryBackgroundRisk of dementia after stroke is a major concern for patients and carers. Reliable data for risk of dementia, particularly after transient ischaemic attack or minor stroke, are scarce. We studied the risks of, and risk factors for, dementia before and after transient ischaemic attack and stroke.MethodsThe Oxford Vascular Study is a prospective incidence study of all vascular events in a population of 92 728 people residing in Oxfordshire, UK. Patients with tran...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Diagnostic accuracy of major stroke types in Chinese adults: A clinical adjudication study involving 40,000 stroke cases
Lancet Reg Health West Pac. 2022 Mar 5;21:100415. doi: 10.1016/j.lanwpc.2022.100415. eCollection 2022 Apr.ABSTRACTBACKGROUND: Widespread use of brain imaging in suspected stroke cases in Chinese adults has prompted the need for clinical adjudication studies of stroke types. We conducted a clinical adjudication study to assess the reporting and diagnostic accuracy of major stroke types.METHODS: The prospective China Kadoorie Biobank recruited >512,000 adults (mean age 52 years, 59% women) from 10 urban and rural areas in China during 2004-2008, and recorded 45,859 first-ever incident stroke cases during an 11-year follow...
Source: Cancer Control - March 14, 2022 Category: Cancer & Oncology Authors: Iain Turnbull Robert Clarke Neil Wright Yu Guo Christina Kartsonaki Pei Pei Alex Hacker Canqing Yu Simon Gilbert Ling Yang Jinyi Zhou Sam Sansome Jun Lv Liming Li Zhengming Chen Yiping Chen Source Type: research

20 years of researching stroke through audit.
This article records and reviews some questions that have been answered using data from the audit: Is the rate of institutional care after rehabilitation a possible measure of outcome? Does stroke unit care in routine practice give the benefits shown in randomized controlled trials? How is the quality of stroke care affected by a patient's age and the time of their stroke? Do patient-reported measures match those obtained from the professionals recording of processes of care? How do the processes of care after stroke affect mortality? Is thrombolysis safe to use in patients over the age of 80? Do staffing levels matter? Do...
Source: Clinical Rehabilitation - June 1, 2018 Category: Rehabilitation Authors: Rudd AG, Hoffman A, Paley L, Bray B Tags: Clin Rehabil Source Type: research

Electroconvulsive therapy and later stroke in patients with affective disorders.
We examined the association between ECT and risk of incident or recurrent stroke. A cohort of 174 534 patients diagnosed with affective disorder between 2005 and 2016 in the Danish National Patient Registry were followed for stroke until November 2016. The association between ECT and stroke was analysed using Cox regression with multiple adjustment and propensity-score matching on sociodemographic and clinical variables. In 162 595 patients without previous stroke, 5781 (3.6%) were treated with ECT. The total number of patients developing stroke during follow-up was 3665, of whom 165 had been treated with ECT. In patients ...
Source: The British Journal of Psychiatry for Mental Science - August 16, 2018 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Acupuncture for stroke: perceptions and possibilities.
CONCLUSION: Interest in the provision of acupuncture for post-acute stroke care was expressed by both NHS practitioners and acupuncturists. Further research is required on the acceptability of acupuncture to patients as well as evidence of its clinical and cost effectiveness. PMID: 31996010 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - January 29, 2020 Category: Complementary Medicine Authors: Robinson N, Ye T, Ronan P, Garbelli PE, Smithard D Tags: Acupunct Med Source Type: research

Genetic associations of adult height with risk of cardioembolic and other subtypes of ischemic stroke: A mendelian randomization study in multiple ancestries
by Andrew B. Linden, Robert Clarke, Imen Hammami, Jemma C. Hopewell, Yu Guo, William N. Whiteley, Kuang Lin, Iain Turnbull, Yiping Chen, Canqing Yu, Jun Lv, Alison Offer, Derrick Bennett, Robin G. Walters, Liming Li, Zhengming Chen, Sarah Parish, for the China Kadoorie Biobank Collaborative Group BackgroundTaller adult height is associated with lower risks of ischemic heart disease in mendelian randomization (MR) studies, but little is known about the causal relevance of height for different subtypes of ischemic stroke. The present study examined the causal relevance of height for different subtypes of ischemic stroke. Met...
Source: PLoS Medicine - April 22, 2022 Category: Internal Medicine Authors: Andrew B. Linden Source Type: research

Secondary stroke prevention services in Canada: a cross-sectional survey and geospatial analysis of resources, capacity and geographic access.
Abstract BACKGROUND: Rapid assessment and management of transient ischemic attacks and nondisabling strokes by specialized stroke prevention services reduces the risk of recurrent stroke and improves outcomes. In Canada, with its vast geography and with 16.8% of the population living in rural areas, access to these services is challenging, and considerable variation in access to care exists. The purpose of this multiphase study was to identify sites across Canada providing stroke prevention services, evaluate resource capacity and determine geographic access for Canadians. METHODS: We developed a Stroke Preve...
Source: cmaj - February 21, 2018 Category: General Medicine Authors: Jewett L, Harroud A, Hill MD, Côté R, Wein T, Smith EE, Gubitz G, Demchuk AM, Sahlas DJ, Gladstone DJ, Lindsay MP Tags: CMAJ Open Source Type: research

Adiposity and risk of ischaemic and haemorrhagic stroke in 0 ·5 million Chinese men and women: a prospective cohort study
Publication date: June 2018 Source:The Lancet Global Health, Volume 6, Issue 6 Author(s): Zhengming Chen, Andri Iona, Sarah Parish, Yiping Chen, Yu Guo, Fiona Bragg, Ling Yang, Zheng Bian, Michael V Holmes, Sarah Lewington, Ben Lacey, Ruqin Gao, Fang Liu, Zengzhi Zhang, Junshi Chen, Robin G Walters, Rory Collins, Robert Clarke, Richard Peto, Liming Li Background China has high stroke rates despite the population being relatively lean. Uncertainty persists about the relevance of adiposity to risk of stroke types. We aimed to assess the associations of adiposity with incidence of stroke types and effect mediation by blood p...
Source: The Lancet Global Health - May 15, 2018 Category: International Medicine & Public Health Source Type: research

Adiposity and risk of ischaemic and haemorrhagic stroke in 0·5 million Chinese men and women: a prospective cohort study
Publication date: June 2018Source: The Lancet Global Health, Volume 6, Issue 6Author(s): Zhengming Chen, Andri Iona, Sarah Parish, Yiping Chen, Yu Guo, Fiona Bragg, Ling Yang, Zheng Bian, Michael V Holmes, Sarah Lewington, Ben Lacey, Ruqin Gao, Fang Liu, Zengzhi Zhang, Junshi Chen, Robin G Walters, Rory Collins, Robert Clarke, Richard Peto, Liming LiSummaryBackgroundChina has high stroke rates despite the population being relatively lean. Uncertainty persists about the relevance of adiposity to risk of stroke types. We aimed to assess the associations of adiposity with incidence of stroke types and effect mediation by bloo...
Source: The Lancet Global Health - July 5, 2018 Category: International Medicine & Public Health Source Type: research

Mood stabilisers and risk of stroke in bipolar disorder.
CONCLUSIONS: Use of carbamazepine and valproic acid, but not lithium and lamotrigine, is associated with increased risk of stroke in patients with bipolar disorder.Declaration of interestNone. PMID: 30295208 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - October 10, 2018 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Substitutions between dairy products and risk of stroke: Results from the EPIC-NL cohort.
In conclusion, whole-fat yoghurt as a substitution for low-fat yoghurt, cheese, butter, buttermilk or milk regardless of fat content was associated with a lower rate of ischemic stroke. PMID: 30868976 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - March 13, 2019 Category: Nutrition Authors: Laursen ASD, Sluijs I, Boer JMA, Verschuren WMM, van der Schouw YT, Jakobsen MU Tags: Br J Nutr Source Type: research

Electroacupuncture for post-stroke overactive bladder: a multi-centre pilot randomized controlled trial.
CONCLUSION: A six-session EA treatment was feasible and appeared to reduce OAB symptoms in post-stroke patients. Further fully powered trials are warranted to confirm the efficacy of EA for those with post-stroke OAB. PMID: 32646228 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - July 8, 2020 Category: Complementary Medicine Authors: Chen H, Wang C, Zhou M, Yan Chan P, Lo Yam L, Lok Lam W, Leung KP, Li SW, Tsang WY, Fung-Leung Ng B, Tat-Chi Ziea E, Yeung WF, Lao L Tags: Acupunct Med Source Type: research