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Therapy: Chemotherapy

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Continuing Chemotherapy Can Be Helpful in Advanced Breast CancerContinuing Chemotherapy Can Be Helpful in Advanced Breast Cancer
Patients with metastatic breast cancer who achieve disease control with paclitaxel/gemcitabine (PG) may fare better following maintenance therapy with these agents. Reuters Health Information
Source: Medscape Medical News Headlines - April 22, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Efficacy and safety of medical cannabinoids in older subjects: a systematic review.
Abstract This systematic review aims to integrate the evidence on indications, efficacy, safety and pharmacokinetics of medical cannabinoids in older subjects. The literature search was conducted using PubMed, EMBASE, CINAHL and Cochrane Library. We selected controlled trials including solely older subjects (≥ 65 years) or reporting data on older subgroups. 105 (74%) papers, on controlled intervention trials, reported the inclusion of older subjects. Five studies reported data on older persons separately. These were randomized controlled trials, including in total 267 participants (mean age 47-78 years). Interve...
Source: Ageing Research Reviews - February 5, 2014 Category: Genetics & Stem Cells Authors: van den Elsen GA, Ahmed AI, Lammers M, Kramers C, Verkes RJ, van der Marck MA, Rikkert MG Tags: Ageing Res Rev Source Type: research

IMPRESS trial data on continuing tyrosine kinase inhibitor therapy after resistance development in lung cancer reported
(European Society for Medical Oncology) Patients whose lung cancer has developed resistance to the drug gefitinib experience no statistically significant improvement in progression-free survival from continued treatment with the drug in addition to chemotherapy, a phase III trial presented at the ESMO 2014 Congress has shown.
Source: EurekAlert! - Cancer - September 28, 2014 Category: Cancer & Oncology Source Type: news

2014 Medical Librarians Month – Meeting Jane
For our 2014 Medical Librarians Month Contest, Basia Delawska-Elliott told us her story about making a difference in a patient’s life. by Basia Delawska-Elliott Health Sciences Librarian Providence St. Vincent Medical Center Portland, OR Meeting Jane I was just coming back from lunch when I ran into Jane at the hospital entrance. I was so glad to see her! Jane was a cancer patient, who used to be a library regular, but she had not come into the library for quite a while and I feared the worst. Jane first came to see us having just received a diagnosis of ovarian cancer. Straight from the doctor’s office she mar...
Source: Dragonfly - November 18, 2014 Category: Databases & Libraries Authors: Patricia Devine Tags: Funding News from Network Members News From NN/LM PNR Source Type: news

Metabolic syndrome in hematologic malignancies survivors: a meta-analysis
Abstract The results from the published studies on whether the risk of metabolic syndrome is high among hematologic malignancies survivors are conflicting. The aims of this study are to conduct a systematic search and assess the literature to determine the available evidence on the association between metabolic syndrome and hematologic malignancies. Two reviewers independently conducted a systemic search to identify the available evidence from PubMed, EMBASE, and Cochrane database from database inception to June 4, 2014. The articles were limited to human studies and published in English. A combined analysis was ...
Source: Medical Oncology - December 4, 2014 Category: Cancer & Oncology Source Type: research

Bacteraemia incidence, causative organisms and resistance patterns, antibiotic strategies and outcomes in a single university hospital ICU: continuing improvement between 2000 and 2013
Conclusions Our strategy predominantly utilizing short-course antibiotic monotherapy remains effective in achieving good clinical outcomes among patients with bloodstream infections, with low rates of antibiotic resistance and clinical relapse. Prospective trials of short-course monotherapy are warranted to assess clinical efficacy and antimicrobial resistance.
Source: Journal of Antimicrobial Chemotherapy - December 16, 2014 Category: Microbiology Authors: De Santis, V., Gresoiu, M., Corona, A., Wilson, A. P. R., Singer, M. Tags: Original research Source Type: research

Cardiomyopathy Associated With Targeted Therapy for Breast Cancer.
CONCLUSION: HER-2 targeted chemotherapy for breast cancer has a higher incidence of associated reversible cardiomyopathy. Patients should be monitored by serial echocardiography starting at the beginning of the treatment and followed by every 3 months until the completion of chemotherapy. Co-ordination between oncologists and cardiologists is needed to develop evidence-based protocols to prevent, identify, monitor and treat trastuzumab-induced cardiomyopathy. PMID: 26897275 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - February 1, 2016 Category: Journals (General) Authors: Sivagnanam K, Rahman ZU, Paul T Tags: Am J Med Sci Source Type: research

The chemo ’s too much, but getting on a clinical trial is gruelling enough
Continuing his account of his illness, Steve Hewlett suffers a setback as he waits nervously for new drugsNow sharp-eyed readers may have spotted that this diary starts the day before the last one was published! By way of a little back story, my doctors have been trying to get me on to a clinical trial featuring new immunotherapy treatments, on the basis that my first line of chemotherapy worked well initially and then failed completely, and the second-line chemo, while it did show signs of working, was proving pretty hard for me to tolerate. But getting on to clinical trials has proved more than a trial in itself!Continue reading...
Source: Guardian Unlimited Science - January 22, 2017 Category: Science Authors: Steve Hewlett Tags: Cancer Health Society Cancer research Medical research Science Source Type: news

Validation and continuing development of a patient-reported survey of small-fiber polyneuropathy symptoms (P4.317)
Conclusions:The SSS captures a wide range of SFPN symptoms, including new patient-identified symptoms. It has good psychometric properties and potential clinical and research utility.Study Supported by: Study supported by the National Institutes of Health [R01-NS093653 and UL1 TR001102]; Lundbeck Foundation Scholarship in Neurology; and the U.S. Department of Defense [GW140169].Disclosure: Dr. Zirpoli has nothing to disclose. Dr. Treister has nothing to disclose. Dr. Lodahl has nothing to disclose. Dr. Lang has nothing to disclose. Dr. Sawilowsky has nothing to disclose. Dr. Campbell has nothing to disclose. Dr. Tworoger h...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zirpoli, G., Treister, R., Lodahl, M., Lang, M., Sawilowsky, S., Campbell, E., Tworoger, S. S., Oaklander, A. L. Tags: Neuroepidemiology: Neuromuscular & amp;amp; Multiple Sclerosis Source Type: research

Comparison of the efficacy and feasibility of laser enucleation of bladder tumor versus transurethral resection of bladder tumor: a meta-analysis
AbstractThe transurethral resection of bladder tumor (TURBT) remains the most widely used method in the surgical treatment of the non-muscle invasive bladder tumor (NMIBT). Despite its popularity, the laser technique has been widely used in urology as an alternative, via the application of transurethral laser enucleation of bladder tumor. The aim of the present study was to compare the efficacy and feasibility between transurethral laser enucleation and transurethral resection of bladder tumor. A systematic search of the following databases was conducted: PubMed, Wed of Science, Cochrane Library, EMBASE, Google scholar, an...
Source: Lasers in Medical Science - August 23, 2017 Category: Laser Surgery Source Type: research

Identification and validation of novel prognostic markers in Renal Cell Carcinoma.
Authors: Rabjerg M Abstract Kidney cancer (Renal Cell Carcinoma (RCC)) is one of the most deadly malignancies due to frequent late diagnosis and poor treatment options. Histologically, RCC embraces a wide variety of different subtypes with the clear cell variant (ccRCC) being the most common, accounting for 75-90% of all RCCs. At present, the surveillance protocols for follow-up of RCC patients after radical nephrectomy are based on the American Joint Committee on Cancers (AJCC) pathological tumor-node-metastasis (TNM) classification system. Other comprehensive staging modalities have emerged and have been implemen...
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Radiotherapy for Gastrointestinal Stromal Tumors.
CONCLUSIONS: Recently reported long-term local control rates indicate that GIST is a radiosensitive disease. This makes radiotherapy a valuable alternative in GIST management with curative intent, especially in patients who (1) cannot tolerate or are resistant to chemotherapy agents, (2) have an unresectable disease, (3) have a gross or microscopic residual disease after surgery, and (4) have a recurrent disease. PMID: 29336374 [PubMed - in process]
Source: Chinese Medical Journal - January 19, 2018 Category: General Medicine Authors: Ozkan EE Tags: Chin Med J (Engl) Source Type: research

Anthracycline and trastuzumab-induced cardiotoxicity in breast cancer.
CONCLUSIONS: Early identification and prompt treatment of subclinical cardiotoxicity may improve cardiologic prognosis of these patients and may allow oncologists to avoid withdrawal of chemotherapy. That is why it becomes always more important the creation of multidisciplinary teams where cardiologists and oncologists work together to ensure optimal care to oncologic patients treated with cardiotoxic agents. PMID: 29687878 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 26, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

E-learning on antibiotic prescribing —the role of autonomous motivation in participation: a prospective cohort study
ConclusionsParticipation in non-obligatory e-learning on antibiotic prescribing is higher in residents with more autonomous motivation. Interventions to increase autonomous motivation could improve participation. Preceding e-learning on antibiotic prescribing with face-to-face education, to explain the importance of the subject, could enhance autonomous motivation and thus optimize e-learning efficiency.
Source: Journal of Antimicrobial Chemotherapy - May 10, 2018 Category: Microbiology Source Type: research

Virtual Reality as a Distraction Intervention to Relieve Pain and Distress During Medical Procedures: A Comprehensive Literature Review
Discussion: Despite these promising results, future long-term randomized controlled trials with larger sample sizes and evaluating not only self-report measures but also physiological variables are needed. Further studies are also required both to establish predictive factors to select patients who can benefit from VR distraction and to design hardware/software systems tailored to the specific needs of different patients and able to provide the greatest distraction at the lowest cost.
Source: The Clinical Journal of Pain - August 9, 2018 Category: Anesthesiology Tags: Review Articles Source Type: research