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Total 443 results found since Jan 2013.

Coexistent TBX1 mutation and chromosomal 20q13.13-q13.2 duplication in an infant with abnormal T-cell receptor rearrangement circle newborn screening results
An 8-day-old, term, male infant of a mother with diabetes and patent ductus arteriosus was transferred from an outlying facility for surgical management of truncus arteriosus (TA), coarctation of the aorta, hypoplastic aortic arch, and anomalous origin of the right subclavian artery. The newborn also had absent thymic shadow apparent on a chest radiograph, hypocalcemia, and abnormal newborn screening (NBS) results for severe combined immunodeficiency (SCID) measuring T-cell receptor rearrangement circles (TRECs); The threshold cycle was 36.86 (reference range,
Source: Annals of Allergy, Asthma and Immunology - October 26, 2018 Category: Allergy & Immunology Authors: Jason K. Lam, Stephen R. Braddock, Charles B. Huddleston, Alan P. Knutsen Tags: Letter Source Type: research

What Is the Best Timing for Endoscopic and Radiographic Surveillance Following Sinonasal Malignancies Treatment?
Close, routine endoscopic and imaging surveillance is needed in the post-treatment setting.
Source: ENTtoday - TRIO Best Practices - October 14, 2018 Category: ENT & OMF Authors: Arjun K. Parasher, MD, MPhil, Edward C. Kuan MD, MBA, Maie A. St. John MD, PhD, Bobby A. Tajudeen MD, and Nithin D. Adappa, MD Tags: Allergy TRIO Best Practices endoscopic surveillance sinonasal malignancies Source Type: research

Advances in asthma in 2017: Mechanisms, biologics, and genetics
This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they can influence the clinical delivery of asthma care. After this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environm...
Source: Journal of Allergy and Clinical Immunology - September 10, 2018 Category: Allergy & Immunology Authors: Mitchell H. Grayson, Scott Feldman, Benjamin T. Prince, Priya J. Patel, Elizabeth C. Matsui, Andrea J. Apter Tags: Advances in allergy, asthma, and immunology series 2018 Source Type: research

Advances in asthma in 2017: Mechanism, biologics, and genetics
This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they may influence the clinical delivery of asthma care. Following this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the envi...
Source: Journal of Allergy and Clinical Immunology - September 10, 2018 Category: Allergy & Immunology Authors: Mitchell H. Grayson, Scott Feldman, Benjamin T. Prince, Priya J. Patel, Elizabeth C. Matsui, Andrea J. Apter Source Type: research

Eosinophilic Pneumonias
Publication date: September–October 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 5Author(s): James Allen, Michael WertThe eosinophilic pneumonias are a heterogeneous group of diseases characterized by an increase in eosinophils in lung tissue or bronchoalveolar lavage fluid. Many, but not all, of the eosinophilic pneumonias are also associated with a peripheral blood eosinophilia. The etiologies of eosinophilic lung disease are wide ranging and include parasitic infections, medications or other toxins, autoimmune and inflammatory disease, and malignancies. Some eosinophilic pne...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Effects of Reslizumab on Asthma Outcomes in a Subgroup of Eosinophilic Asthma Patients with Self-Reported Chronic Rhinosinusitis with Nasal Polyps
CONCLUSIONPatients with eosinophilic asthma and self-reported CRSwNP, with and without aspirin sensitivity, are highly responsive to treatment with reslizumab for asthma-related outcomes. These findings suggest that prospective investigation of reslizumab in this patient population is warranted.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 5, 2018 Category: Allergy & Immunology Source Type: research

Eosinophilic Pneumonias
Publication date: Available online 4 May 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): James Allen, Michael Wert The eosinophilic pneumonias are a heterogeneous group of diseases characterized by an increase in eosinophils in lung tissue or bronchoalveolar lavage fluid. Many, but not all, of the eosinophilic pneumonias are also associated with a peripheral blood eosinophilia. The etiologies of eosinophilic lung disease are wide ranging and include parasitic infections, medications or other toxins, autoimmune and inflammatory disease, and malignancies. Some eosinophilic pneumonias have ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 11, 2018 Category: Allergy & Immunology Source Type: research

Endovascular Aortic Repair Follow up Protocol Based on Contrast Enhanced Ultrasound Is Safe and Effective.
CONCLUSIONS: The introduction of a CEUS based protocol for EVAR follow up was safe and effective and it was similar to the previous CTA based follow up protocol with regard to identification of endoleaks in a mid-term period. Moreover, CEUS allowed for 90% reduction of CTA, thereby decreasing radiation exposure for patients. PMID: 29673811 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - April 17, 2018 Category: Surgery Authors: Chisci E, Harris L, Guidotti A, Pecchioli A, Pigozzi C, Barbanti E, Ercolini L, Michelagnoli S Tags: Eur J Vasc Endovasc Surg Source Type: research

Eccentric, mature osseous cap: A distinct imaging feature of sinonasal osteoblastoma.
CONCLUSION: Sinonasal osteoblastoma is an extremely rare entity with undefined imaging characteristics to guide preoperative decision-making. Here we reported, to our knowledge, the first description of a characteristic imaging sign of an eccentric, mature osseous cap, which corresponded histologically to a single peripheral layer rim of osteoblasts, a unique trait of osteoblastoma. PMID: 29644901 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - March 1, 2018 Category: ENT & OMF Authors: Dua SG, Locker PH, Rossi IR, Jandali D, Gattuso P, Batra PS, Tajudeen BA Tags: Am J Rhinol Allergy Source Type: research

Granulomatous-Lymphocytic Interstitial Lung Disease in 22q11.2 Deletion Syndrome: a Case Report and Literature Review
We describe the second reported case of GLILD in a patient with 22q11.2 deletion syndrome (22q11.2DS) and review the recent literature surrounding GLILD.Recent FindingsGLILD is characterized by granulomata and lymphoproliferation. Consensus statements and retrospective and case-control studies have better elucidated the clinicopathological and radiographic manifestations of GLILD, allowing for its differentiation from similar conditions like sarcoidosis. Gaps of knowledge remain, however, particularly regarding optimal management strategies. Combination therapies targeting T and B cell populations have recently shown favor...
Source: Current Allergy and Asthma Reports - February 22, 2018 Category: Allergy & Immunology Source Type: research

Retrospective Evaluation of Factors Related to the Outcomes of Regenerative Therapy for Implants Affected by Peri-implantitis.
Authors: Froum SJ, Rosen PS, Wang WC, Froum SH, Vinayak S Abstract The aim of this retrospective study was to examine the histories of 100 patients with 170 implants that were consecutively treated and reported in a previous study to identify which patient and implant factors might have affected the outcomes of therapy. Patient factors included history of periodontitis, hypertension, cardiac problems, rheumatoid arthritis, smoking, and penicillin allergy. Implant factors included whether the prosthesis was cemented or screw retained and initial bone loss (≤ 50% or > 50% of implant length). Frequency of mainten...
Source: International Journal of Periodontics and Restorative Dentistry - February 16, 2018 Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research

Treatment of chronic rhinosinusitis with dornase alfa in patients with cystic fibrosis: a systematic review
ConclusionTopical intranasal dornase appears to improve sinonasal symptoms in CF patients to a greater degree than saline alone. The impact on other outcomes is less clear. Larger studies are needed to fully elucidate the true efficacy of dornase alfa in the treatment of CRS in CF patients.
Source: International Forum of Allergy and Rhinology - January 11, 2018 Category: Allergy & Immunology Authors: Gopi B. Shah, Linde Keyzer, Joy A. Russell, Ashleigh Halderman Tags: ORIGINAL ARTICLE Source Type: research

Allergic Colitis With Pneumatosis Intestinalis in an Infant
We report this case of cow’s milk protein allergy, managed successfully with elimination of dietary antigen, to highlight the unusual finding of pneumatosis intestinalis on abdominal x-ray, a radiographic hallmark associated with necrotizing enterocolitis. Detailed patient’s history, clinical presentation, and physical examinations are discussed for cow’s milk protein allergy and necrotizing enterocolitis.
Source: Pediatric Emergency Care - January 1, 2018 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

What is DIOS?
Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are l...
Source: PediatricEducation.org - December 18, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news