What is DIOS?

Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are living longer with improved morbidity because of new treatments including lung transplantation but they also are at higher risk of having gastrointestinal problems over their lifespan. Gastrointestinal problems in patients with CF include: Pancreas Second most frequent organ affected after the lung Concentrated pancreatic juice and thickened secretions can increase obstruction leading to acute or chronic injury and inflammation Pancreatic insufficiency Most (~90%) patients have exocrine pancreatic insufficiency Greasy stools, abdominal bloating, flatulence, diarrhea and poor weight gain are symptoms Treatment is pancreatic enzyme replacement therapy (PERT), proton pump inhibitors are used sometimes also Fat soluble vitamins (A, D, E, and K) can occur and usually are also supplemented Poor nutrition Patients have increased nutrition needs because of the ex...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

Related Links:

Publication date: 2018Source: Materials Today: Proceedings, Volume 5, Issue 11, Part 3Author(s): Aswin G. Nath, E. Sarath Krishnan, Sachin Cheriyan, P.S. Vishnu, A. Krishnan, Pramod Sreedharan, Ganesha UdupaAbstractA miniaturize hydraulic gear pump is used for pressure generation in the fluidic actuators used in some of the medical and bio-medical devices such as blood pressure monitoring devices, artificial heart pump and prosthetic hands. A large variety of sizes of hydraulic pumps is commercially available. Proper design of the pump depends significantly on the application. Various designs of miniature hydraulic pumps h...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: 2018Source: Materials Today: Proceedings, Volume 5, Issue 11, Part 3Author(s): K.S. Pujari, D.V. Patil, Gurunath MewundiAbstractGas tungsten arc welding (GTAW) quality is mainly characterized by the weld pool geometry. This is because the weld pool geometry is highly influential in determining the mechanical properties of the weld joint. In this paper, the selection of process parameters for obtaining optimal weld pool geometry in the GTAW of AA 7075-T6 aluminium alloy is presented. Taguchi method is stastical tool widely using to optimize process parameters as a single response problem. The single respon...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
This study aimed to examine the relationship between corin expression and circulating brain natriuretic peptide in patients with left ventricular (LV) dysfunction.Circulating levels of B-type natriuretic peptide (BNP) can be an indicator of LV dysfunction. The 32-amino-acid BNP is cleaved by corin, a cardiac serine protease, from its108-amino-acid pro-brain natriuretic peptide (proBNP) precursor.This study included 25 patients with idiopathic dilated cardiomyopathy (DCMP) and LV dysfunction and 44 heart transplant recipients with normal LV function who underwent diagnostic left and right heart catheterization. Blood sample...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
CONCLUSION: The use of SGLT2 inhibitors in insulin treated T2D patients resulted in reduction of HbA1c, which was associated to weight loss, cHDL increase and SBP decrease. PMID: 30503071 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
CONCLUSION: According to the results obtained, females and patients undergoing treatment with apixaban presented lower haemorrhagic risk, although there are doubts about whether this better safety profile is related to underdosing, which could influence its effectiveness. Therefore, these results should be analysed with caution and further studies are needed to confirm this data. PMID: 30503070 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
CONCLUSION: The results obtained show a sub-optimal adherence to treatment for the 3chronic diseases studied. Adherence increased with the number of chronic diseases, while sex, age and number of drugs did not show a consistent effect. It is necessary to investigate if there are other factors that may influence therapeutic adherence, since improving adherence may have a greater impact on health than any progress in therapies. PMID: 30503066 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Gullón A, Sánchez Fuentes D, López-de-Sá E, Martí-Almor J, Barón-Esquivias G, Jiménez López J, Del Mar Contreras Muruaga M, Suárez Fernández C Abstract The present article provides an update on anticoagulant treatment in patients with atrial fibrillation in distinct clinical scenarios requiring particular considerations, such as ischaemic heart disease, electrical cardioversion, pulmonary vein ablation, the presence of valvular disease with or without prosthetic valves, and renal insufficiency, as well as old age and frailty. In patients...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
CONCLUSIONS: Patients with SLE are similar candidates to KT than that with other immunological kidney diseases. There was no recurrence of the disease in any patient. PMID: 30502305 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A Abstract There are many useful biomarkers for initial diagnosis and the management of inflammatory bowel disease. Serologic biomarkers have been traditionally used because they are widely disposable, but recently faecal biomarkers, especially faecal calprotectin, have acquired great importance as they have shown to be more precise when establishing suspicion of the disease and also as predictors of mucosal healing or persistence of inflammatory activity. Faecal calprotectin is a good tool for predicting abnormal endoscopic s...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Publication date: March 2019Source: Results in Physics, Volume 12Author(s): Satoru Ueda, Satoshi Koizumi, Yasuyuki TsutsumiAbstractIn order to elucidate the cell performance related to swelling or flooding of the polymer electrolyte membrane (Nafion®), we performed in-situ measurements of small-angle neutron scattering (SANS) and neutron radiography (NR) for a polymer electrolyte fuel cell (PEFC) during electricity generation. SANS determined the swelling behavior by observing inter-particle scattering of water-clusters and mean inter-distance of nm order (Lw). With increased current density, Lw heterogeneously increas...
Source: Results in Physics - Category: Physics Source Type: research
More News: Acid Reflux | Allergy | Allergy & Immunology | Appendicitis | Atresia | Bile | Bronchiolitis | Cancer & Oncology | Cardiology | Children | Chloride | Cholesterol | Chronic Pain | Cirrhosis | Constipation | Cystic Fibrosis | Databases & Libraries | Diabetes | Diabetic Ulcers | Emergency Medicine | Endocrinology | Fatty Liver Disease (FLD) | Gallstones | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Heart | Heart Transplant | Hernia | Inflammatory Bowel Disease | Internet | Learning | Liver | Liver Disease | Liver Transplant | Lung Transplant | Nasogastric Intubation | Nuclear Medicine | Nutrition | Pain | Pancreas | Pancreatitis | Parenteral Nutrition | Pediatric Hernia | Pediatrics | Peptic Ulcer | Peritonitis | Probiotics | Radiography | Radiology | Respiratory Medicine | Study | Transplant Surgery | Transplants | Universities & Medical Training | Urology & Nephrology | Vitamins