What is DIOS?

Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are living longer with improved morbidity because of new treatments including lung transplantation but they also are at higher risk of having gastrointestinal problems over their lifespan. Gastrointestinal problems in patients with CF include: Pancreas Second most frequent organ affected after the lung Concentrated pancreatic juice and thickened secretions can increase obstruction leading to acute or chronic injury and inflammation Pancreatic insufficiency Most (~90%) patients have exocrine pancreatic insufficiency Greasy stools, abdominal bloating, flatulence, diarrhea and poor weight gain are symptoms Treatment is pancreatic enzyme replacement therapy (PERT), proton pump inhibitors are used sometimes also Fat soluble vitamins (A, D, E, and K) can occur and usually are also supplemented Poor nutrition Patients have increased nutrition needs because of the ex...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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Publication date: September 2018Source: Advances in Medical Sciences, Volume 63, Issue 2Author(s): Thomas J. Humphries, Brittny Rule, Augustina Ogbonnaya, Michael Eaddy, Orsolya Lunacsek, Lois Lamerato, Jennifer PocoskiAbstractPurposePrevious retrospective claims database analyses reported increased prevalence and earlier onset of cardiovascular comorbidities in patients with versus without hemophilia A. A comprehensive chart review was designed to further investigate previous findings.MethodsThis retrospective chart review study was conducted at Henry Ford Health System (Detroit, MI, USA). Baseline demographics, bleeding ...
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Publication date: Available online 19 July 2018Source: Plant Physiology and BiochemistryAuthor(s): Mohammad Javad Ahmadi Lahijani, Mohammad Kafi, Ahmad Nezami, Jafar Nabati, Mohammad Zare Mehrjerdi, Shirin Shahkoomahally, John ErwinAbstractRising atmospheric CO2 concentrations are expected to impact the productivity of plants. Cultivars demonstrate different responses to CO2 levels, hence, screening and recognizing the cultivars with a higher capacity for translocation of photoassimilates would certainly be beneficiary. To investigate the interactive impact of enhancing CO2 on physiology, cellular fine structure and photoa...
Source: Plant Physiology and Biochemistry - Category: Biochemistry Source Type: research
In conclusion, ART exhibited protective effect on HG-induced HBZY-1 cells by inhibiting the inflammatory response, oxidative stress and ECM accumulation. The TLR4/NF-κB/NLRP3 inflammasome pathway was involved in the protective effect of ART. The results suggested that ART might be a potential therapy agent for the DN treatment.
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): Tang Gao, Xiaozheng Cao, Anyao Bi, Jie Dong, Shuai Huang, Xueyan Huang, Shijun Wen, Wenbin ZengAbstractFormaldehyde (FA) is a product of an endogenous production that is formed through demethylase and oxidase enzymes, which regulate epigenetics and metabolism. However, the presence of abnormally high levels of FA are often associated with a variety of disease pathologies, including chronic liver, heart and neurodegenerative diseases, in addition to diabetes and various cancers. Hence, a more efficient tool for monitoring FA in...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
25 August 2018, Irving, United States
Source: Scientific and Medical Events on Global Events List - Category: Science Source Type: events
8 September 2018, Rochester, United States
Source: Scientific and Medical Events on Global Events List - Category: Science Source Type: events
Conclusion: Silodosin showed better efficacy in the stone expulsion rate and time with comparable safety of both drugs, with nonsignificant more retrograde ejaculation in silodosin.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
Authors: Kaier TE, Alaour B, Marber M PMID: 30019910 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
[Abstract unavailable] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Some years ago, we observed that falling in the previous year was more frequent in patients with cirrhosis than in healthy controls, and showed for the first time that cirrhotic patients, mainly those with cognitive dysfunction, are predisposed to falling ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Falls Source Type: news
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