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Every 15 Minutes, Someone In The US Dies Of A Drug-Resistant Superbug
(CNN) — Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention. That’s about 35,000 deaths each year from drug-resistant infections, according to the landmark report. The report places five drug-resistant superbugs on the CDC’s “urgent threat” list — two more germs than were on the CDC’s list in 2013, the last time the agency issued a report on antibiotic resistance. Genetic research shows germs have become especially adep...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 16, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Featured Health Antibiotics Bacteria CNN Superbugs Source Type: news

Sinusitis
Urticaria is characterized by the appearance of hives or angioedema.1 Chronic urticaria is defined by urticarial episodes that last more than 6 weeks, occurring daily or several times per week.2 Although acute urticaria is commonly associated with infections,3 most cases of chronic urticaria have no identifiable cause. Nevertheless, several reports documented chronic urticaria from infectious causes including Helicobacter pylori.4 Studies show association of upper respiratory infections, including sinusitis, with chronic urticaria with remission after antibiotic therapy.
Source: Annals of Allergy, Asthma and Immunology - November 22, 2019 Category: Allergy & Immunology Authors: Richard A. Page Tags: Correspondence Source Type: research

The Role of Macrolides and Doxycycline in Chronic Rhinosinusitis
This article reviews the clinical applications for macrolide and doxycycline use in CRS, considerations for dosing and duration of treatment, and important side effects and drug interactions ass ociated with these medications.
Source: Immunology and Allergy Clinics of North America - January 17, 2020 Category: Allergy & Immunology Authors: Katherine A. Lees, Richard R. Orlandi, Gretchen Oakley, Jeremiah A. Alt Source Type: research

Odontogenic Sinusitis
Odontogenic sinusitis is a unique cause of sinus disease that deserves special consideration. An astute clinician can elicit historical findings such as recent dental work, and symptoms such as unilateral facial pain and foul drainage, despite a relatively benign oral cavity examination. Otolaryngologists and dental professionals who care for these patients must be able to interpret imaging studies for dental disorder such as periapical abscesses and periodontal disease. Treatment is frequently some combination of antibiotic therapy, dental procedures, and endoscopic sinus surgery. More prospective studies are needed to de...
Source: Immunology and Allergy Clinics of North America - January 21, 2020 Category: Allergy & Immunology Authors: Hillary A. Newsome, David M. Poetker Source Type: research

Association between early antibiotic treatment and clinical outcomes in children hospitalized for asthma exacerbation
Early antibiotic therapy was associated with prolonged hospital stay, elevated hospitalization costs, and risk of probiotic use without improving the risks of treatment failure and readmission among children hospitalized for asthma.
Source: Journal of Allergy and Clinical Immunology - June 2, 2020 Category: Allergy & Immunology Authors: Yusuke Okubo, Kenta Horimukai, Nobuaki Michihata, Kojiro Morita, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga Source Type: research

Otitis Media and Inborn Errors of Immunity
AbstractPurpose of ReviewThe aim of this review is as follows: (1) to present the role of otitis as a warning sign for inborn errors of immunity (IEI), (2) to establish which patients presenting otitis should be investigated for IEI, (3) to review data about main IEI associated with otitis-prone patients.Recent FindingsOtitis media is a very common infection in general population. The concept of otitis-prone children established a certain frequency of the infections in order to look for conditions leading to them. The confirmation of middle ear impairment by specialists has demonstrated better confiability. The hallmarks f...
Source: Current Allergy and Asthma Reports - July 10, 2020 Category: Allergy & Immunology Source Type: research

Management of Pediatric Chronic Rhinosinusitis
AbstractPurpose of ReviewChronic pediatric rhinosinusitis is a common entity, with an annual incidence of 4% in the US schoolchildren ’s population. The predominant contributing factor in younger children is adenoid pathology and in older children, allergic rhinitis. Recent research on sinus microbiome, biofilm, inflammatory response, and therapeutic alternatives is providing new insights in this prevalent disease.Recent FindingsAdenoid size does not correlate with the severity of the disease suggesting that it is due to the biofilms observed in both adenoiditis and hypertrophic adenoids. There is new consensus among the...
Source: Current Treatment Options in Allergy - July 20, 2020 Category: Allergy & Immunology Source Type: research

A Patient with CTLA-4 Haploinsufficiency with Multiple Autoimmune Presentations: A Case Report.
Authors: Zaremehrjardi F, Baniadam L, Seif F, Arshi S, Bemanian MH, Shokri S, Rezaeifar A, Fallahpour M, Nabavi M Abstract Increased susceptibility to autoimmunity, malignancy, and allergy in addition to recurrent infections are the main characteristics suggesting for the primary immunodeficiency diseases (PID). CTLA-4 is predominantly expressed on activated and regulatory T-cells, which can bind to CD80/CD86 molecules on antigen-presenting cells as a negative regulator. Here, we describe a 24-year-old male born from consanguineous parents with heterozygous CTLA-4 mutation who presented with multiple autoimmune dis...
Source: Iranian Journal of Immunology - October 2, 2020 Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research

Determinants of doctors' antibiotic prescriptions for patients over 75 years old in the terminal stage of palliative care.
CONCLUSION: Antibiotic use in end-of-life EPs in PC seems frequent. In accordance with the principle of beneficence, its goal of often symptom-related; that said, in the absence of scientific data, antibiotic prescription in end-of-life situations should be individualized in view of observing the other ethical caregiving principles (beneficence, non-maleficence, justice, patient autonomy) and reevaluated daily. PMID: 33075403 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - October 22, 2020 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

Development and characterisation of a multi-species COPD biofilm
This study highlights the need to utilise multi-species biofilms to study the pathogenesis of disease and emphasises the importance of selecting appropriate antimicrobial therapies.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Short, B., Williams, C., Litherland, G., Lundy, F., Mackay, W., Ramage, G. Tags: Allergy and immunology Source Type: research

Bacterial acute non necrosing cellulitis (erysipelas) in adult.
Authors: Dezoteux F, Staumont-Sallé D Abstract Erysipelas is defined by a sudden onset (with fever) preceding the appearance of a painful, infiltrated, erythematous plaque, accompanied by regional lymphadenopathy. It is usually localized on the lower limbs, but it can occur on the face. It is due to β-hemolytic streptococcus A and more rarely to staphylococcus aureus. It is important to establish the diagnosis and eliminate the non-bacterial causes of inflammatory edema. The other diagnoses frequently found are contact eczema, acute arthritis, bursitis, inflammatory flare-up of chronic dermohypodermitis of venous...
Source: Revue de Medecine Interne - November 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

The role of bacterial DNA containing CpG motifs in diseases.
Abstract Bacterial DNA containing unmethylated CpG motifs can activate immune cells to release proinflammatory cytokines. Here, the role of bacterial DNA containing CpG motifs in diseases with a focus on arthritis is discussed. Our studies demonstrate that the intraarticular injection of bacterial DNA and oligodeoxynucleotides containing CpG motifs (CpG ODN) induced arthritis. The induction of arthritis involves the role of macrophages over other cells such as neutrophils, NK cells, and lymphocytes. TNF-α and TNFRI play an important role in the development of arthritis. NF-κB also plays a critical regulatory rol...
Source: Journal of Leukocyte Biology - February 2, 2021 Category: Hematology Authors: Zhou J, Deng GM Tags: J Leukoc Biol Source Type: research

Antibiotic use evaluation in hospitalized pediatric patients with respiratory tract infections: A retrospective chart review study.
CONCLUSION: We found relatively low adherence to international guidelines in our center that could be related to restricted definitions of optimal antibiotic therapy. Despite most patients received logical antimicrobial therapy, actions should be taken into account to reach optimal antibiotic usage. PMID: 33602106 [PubMed - as supplied by publisher]
Source: Current Drug Safety - February 17, 2021 Category: Drugs & Pharmacology Authors: Mahboobipour AA, Baniasadi S, Shahrebabaki ES, Nejad ST, Hassanzad M Tags: Curr Drug Saf Source Type: research

Antibiotic use evaluation in hospitalized pediatric patients with respiratory tract infections: A retrospective chart review study
CONCLUSION: We found relatively low adherence to international guidelines in our center that could be related to restricted definitions of optimal antibiotic therapy. Despite most patients received logical antimicrobial therapy, actions should be taken into account to reach optimal antibiotic usage.PMID:33602106 | DOI:10.2174/1574886316666210218104644
Source: Current Drug Safety - February 19, 2021 Category: Drugs & Pharmacology Authors: Amir Ali Mahboobipour Shadi Baniasadi Elahe Saberi Shahrebabaki Sabereh Tashayoie Nejad Maryam Hassanzad Source Type: research

Antibiotic desensitization therapy in secondary syphilis and Listeria infection: case reports and review of desensitization therapy
Hawaii Med J. 2011 Dec;70(12):266-8.ABSTRACTTwo adult cases, one of secondary syphilis and one of Listeria monocytogenes bacteremia, in which antibiotic desensitization therapy was utilized to assist treatment of active infection in the face of severe penicillin allergy. Clinical considerations are discussed that led to the decision to employ a formal desensitization procedure. Antibiotic desensitization protocols can facilitate optimal and safe antibiotic therapy in the appropriate clinical setting.PMID:22187514 | PMC:PMC3242422
Source: Hawaii Medical Journal - December 22, 2011 Category: General Medicine Authors: Gil Magpantay Anthony P Cardile Cristian S Madar Gunther Hsue Conrad Belnap Source Type: research