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Total 2046 results found since Jan 2013.

Resources Assessment for Penicillin Allergy Testing Performed by Pharmacists at the Patient's Bedside
CONCLUSIONS AND RELEVANCE: This study describes penicillin allergy testing and the number of median weekly hospital pharmacist FTEs required, which was approximately 0.15. These data may aid in the implementation of this safe intervention that promotes narrower-spectrum antibiotherapy.PMID:33703922 | DOI:10.1177/10600280211002412
Source: The Annals of Pharmacotherapy - March 11, 2021 Category: Drugs & Pharmacology Authors: Sophie Gaudreau Genevi ève Bourque Kevin C ôté Cl ément Nutu Marie-France Beauchesne Audrey-Anne Longpr é Bianca Beloin-Jubinville Lorraine Legeleux Martin Blaqui ère Philippe Martin M élanie Gilbert Source Type: research

Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy
In this study, we designed a mouse model of food allergy and examined the effect of theaflavins using the severity of diarrhea, a symptom of food allergy, as an indicator. The administration of a black tea extract rich in theaflavins or theaflavin 1 (subgroup of theaflavins) to mice reduced the severity of diarrhea when compared with a normal diet. A reduction in malondialdehyde levels, a key marker of lipid peroxidation, was also observed. Overall, these data suggest that theaflavins may potentially inhibit food allergy by alleviating oxidative stress in the colon and can be a potential food material for prevention of food allergy.
Source: Journal of Natural Medicines - March 1, 2023 Category: Drugs & Pharmacology Source Type: research

Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization.
Abstract The physicochemical nature of allergen molecules differ from the liquid phase to the solid phase. However, conventional allergy tests are based on the detection of immunoglobulin (Ig)E binding to immobilized allergens. We recently developed an in vitro allergy testing method using a luciferase-reporting humanized rat mast cell line to detect IgE crosslinking-induced luciferase expression (EXiLE test). The aim of the present study was to evaluate the effects of antigen immobilization on the results of different in vitro allergy tests using two anti-ovalbumin (OVA) antibodies (Abs), E-C1 and E-G5, with diff...
Source: Biological and Pharmaceutical Bulletin - October 13, 2016 Category: Drugs & Pharmacology Authors: Okamoto-Uchida Y, Nakamura R, Matsuzawa Y, Soma M, Kawakami H, Ishii-Watabe A, Nishimaki-Mogami T, Teshima R, Saito Y Tags: Biol Pharm Bull Source Type: research

Impact of Penicillin Allergy on Time to First Dose of Antimicrobial Therapy and Clinical Outcomes.
The objective of this study was to evaluate the impact of a listed penicillin allergy on the time to first dose of antibiotic in a Veterans Affairs hospital. Additional clinical outcomes of patients with penicillin allergies were compared with those of patients without a penicillin allergy. METHODS: A retrospective chart review of veterans admitted through the emergency department with a diagnosis of pneumonia, urinary tract infection, bacteremia, and sepsis from January 2006 to December 2015 was conducted. The primary outcome was time to first dose of antibiotic treatment, defined as the time from when the patient pr...
Source: Clinical Therapeutics - October 9, 2017 Category: Drugs & Pharmacology Authors: Conway EL, Lin K, Sellick JA, Kurtzhalts K, Carbo J, Ott MC, Mergenhagen KA Tags: Clin Ther Source Type: research

Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo.
Conclusion, SSA could inhibits IgE-independent allergy, but not IgE-dependent allergy, and this effect involves the Mrgprx2 pathway. This study provided a new sight on Pseudo-allergy and its therapy. PMID: 29274317 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - December 20, 2017 Category: Drugs & Pharmacology Authors: Wang N, Che D, Zhang T, Liu R, Cao J, Wang J, Zhao T, Ma P, Dong X, He L Tags: Biochem Pharmacol Source Type: research

Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy
Conclusion Turmeric significantly ameliorated food allergic symptoms in a mouse model of food allergy. The turmeric as an anti-allergic agent showed immune regulatory effects through maintaining Th1/Th2 immune balance, whereas curcumin appeared immune suppressive effects. Therefore, we suggest that administration of turmeric including various components may be useful to ameliorate Th2-mediated allergic disorders such as food allergy, atopic dermatitis, and asthma. Graphical abstract
Source: Journal of Ethnopharmacology - September 4, 2015 Category: Drugs & Pharmacology Source Type: research

Allergy immunotherapy: The future of allergy treatment.
Abstract Allergic respiratory disease represents a significant and expanding health problem worldwide. Allergic symptoms, such as asthma and hay fever, cause sleep impairment and reduce school and work performance. The cost to society is substantial. Allergen avoidance and pharmacotherapy cannot control the disease. Only allergy immunotherapy has disease-modifying potential and should be included in optimal treatment strategies. Allergy immunotherapy was first administered as subcutaneous injections and has been practiced for the past 100 years or so. Recently, tablet-based sublingual allergy immunotherapy (SLIT) ...
Source: Drug Discovery Today - August 28, 2015 Category: Drugs & Pharmacology Authors: Larsen JN, Broge L, Jacobi H Tags: Drug Discov Today Source Type: research

A multidimensional antimicrobial stewardship intervention targeting aztreonam use in patients with a reported penicillin allergy
Conclusion A pharmacist-led antimicrobial stewardship intervention facilitated antibiogram-driven antibiotic therapy while reducing aztreonam use in patients without an anaphylactic penicillin allergy. Further trials are needed to assess the utility of similar antimicrobial stewardship interventions for patients with penicillin allergy.
Source: International Journal of Clinical Pharmacy - January 14, 2016 Category: Drugs & Pharmacology Source Type: research

Allergy tests do not predict food triggers in adult patients with eosinophilic oesophagitis. A comprehensive prospective study using five modalities
ConclusionsNone of the currently‐available allergy tests predicts food triggers for EoE. Exclusion‐rechallenge methodology with oesophageal histological assessment remains the only effective investigation. The same food triggers were identified in this southern hemisphere cohort as previously described.
Source: Alimentary Pharmacology and Therapeutics - May 31, 2016 Category: Drugs & Pharmacology Authors: H. Philpott, S. Nandurkar, S. G. Royce, F. Thien, P. R. Gibson Tags: Original Article Source Type: research

Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment, and Prevention Programs.
CONCLUSIONS: Nickel allergy is a relevant issue of public health with significant personal, social and economic impact. This review summarize epidemiology, pathomechanism, clinical patterns, treatment and prevention programs. PMID: 31994473 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 30, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Peanut Allergen Powder-dnfp: A Novel Oral Immunotherapy to Mitigate Peanut Allergy.
Conclusions: In patients 4 to 17 years old, PAP mitigated ARs, including anaphylaxis, that may occur with accidental peanut exposure. Although there are risks, it was efficacious in more than two-thirds of participants in phase 2 and phase 3 efficacy trials. PMID: 32718178 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - July 27, 2020 Category: Drugs & Pharmacology Authors: Dougherty JA, Wagner JD, Stanton MC Tags: Ann Pharmacother Source Type: research

Review article: the diagnosis and management of food allergy and food intolerances
ConclusionsFood allergies are more common in children, can be life‐threatening and are distinct from food intolerances. Food intolerances may pose little risk but since functional disorders are so prevalent, greater efforts to understand adverse effects of foods in functional disorders are warranted.
Source: Alimentary Pharmacology and Therapeutics - October 16, 2014 Category: Drugs & Pharmacology Authors: J. L. Turnbull, H. N. Adams, D. A. Gorard Tags: Review Article Source Type: research

Feasibility, Benefits, and Limitations of a Penicillin Allergy Skin Testing Service.
CONCLUSION: We conclude that institutions with high percentages of patients receiving non-β-lactams because of penicillin allergy labels would likely benefit the most from a penicillin skin testing service. PMID: 28152605 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - January 31, 2017 Category: Drugs & Pharmacology Authors: Narayanan PP, Jeffres MN Tags: Ann Pharmacother Source Type: research

A Cost-Minimisation Analysis Comparing Sublingual Immunotherapy to Subcutaneous Immunotherapy for the Treatment of House Dust Mite Allergy in a Swedish Setting
ConclusionIn conclusion, cost-savings of €6800 over 3 years are expected from treating HDM allergy with SQ® SLIT-tablet as compared to SQ® SCIT, including costs for treatment, healthcare visits, travelling and lost productivity. The reduced number of healthcare visits compensates for higher medication costs.
Source: Clinical Drug Investigation - March 22, 2017 Category: Drugs & Pharmacology Source Type: research

Recent advances in the management of allergy associated diseases in children.
Authors: Zhu L, Zhu F, Zhang ZK Abstract The allergy symptoms could arise from variable organ systems and have fluctuating nature in severity as well as symptoms. Moreover, these symptoms could be related to multiple pathological states like common cold, chronic obstipation, diarrhea, etc. On the other hand, food allergy diagnosis that usually spread by IgE-mediated inhalant also poses a great challenge in front of the scientific fraternity. So far, many advances in the field of allergy diagnosis, as well as therapeutics, have been made. These advances include skin prick testing (SPT), serum specific IgE (sIgE) lev...
Source: European Review for Medical and Pharmacological Sciences - November 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research