Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo.

Conclusion, SSA could inhibits IgE-independent allergy, but not IgE-dependent allergy, and this effect involves the Mrgprx2 pathway. This study provided a new sight on Pseudo-allergy and its therapy.
PMID: 29274317 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - December 20, 2017 Category: Drugs & Pharmacology Authors: Wang N, Che D, Zhang T, Liu R, Cao J, Wang J, Zhao T, Ma P, Dong X, He L Tags: Biochem Pharmacol Source Type: research