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Total 443 results found since Jan 2013.

Bone involvement: Histopathological evidence for endoscopic management of sinonasal inverted papilloma
ConclusionHistopathological evidence of bone involvement indicates the importance of removal of the underlying bone at the time of endoscopic tumor resection. We hypothesized that bone involvement including bone invasion and osteogenesis may be induced by the tumor, and any microscopic lesion in the bony crevices probably indicates recurrence of SIP. Furthermore, infiltration of inflammatory cells may facilitate bone involvement and cause recurrence. Level of Evidence3b. Laryngoscope, 2017
Source: The Laryngoscope - July 19, 2017 Category: ENT & OMF Authors: Na Liang, Zhenxiao Huang, Honggang Liu, Junfang Xian, Qian Huang, Bing Zhou Tags: Allergy/Rhinology Source Type: research

Clinical Features of Psoriatic Arthritis: a Comprehensive Review of Unmet Clinical Needs
AbstractPsoriatic arthritis (PsA) is a form of inflammatory arthritis (IA) affecting approximately 0.25% of the population. It is a heterogeneous disorder associated with joint damage, disability, disfiguring skin disease and in severe cases, premature mortality. Inherently irreversible and frequently progressive, the process of joint damage begins at, or before, the clinical onset of disease. Early recognition and intervention is thus crucial to patient outcome. At disease onset, however, PsA often resembles other forms of arthritis —especially rheumatoid arthritis (RA). Despite the similarities between PsA and RA, thei...
Source: Clinical Reviews in Allergy and Immunology - July 27, 2017 Category: Allergy & Immunology Source Type: research

Unmet Needs in Axial Spondyloarthritis
AbstractDuring the past decade, the well-known disease called ankylosing spondylitis has come to be considered as a subset of the broader entity referred as axial spondyloarthritis (axSpA), which also includes non-radiographic axSpA. The need of this new classification was aimed to improve the sensitivity for an early diagnosis, to reduce diagnostic delay, and to allow an early treatment. Although there is improvement in the recognition, the management of patients, and the treatment strategies of axSpA, unmet needs persist. There is still a substantial gap of 5 –8 years between the onset of symptoms and the diagnosis of...
Source: Clinical Reviews in Allergy and Immunology - August 4, 2017 Category: Allergy & Immunology Source Type: research

MR Imaging of Mediastinal Masses
Abstract: The mediastinum contains vital vascular and nonvascular structures and organs, and a wide variety of abnormalities may arise from this region of the thorax. Although mediastinal masses may be initially detected on chest radiography, cross-sectional imaging plays an important role in the identification and evaluation of mediastinal lesions, enabling the formulation of focused differential diagnoses and ultimately guiding management. Computed tomography (CT) is considered the imaging modality of choice for evaluating most mediastinal masses; however, the role of magnetic resonance (MR) imaging continues to expand, ...
Source: Topics in Magnetic Resonance Imaging - August 1, 2017 Category: Radiology Tags: Review Articles Source Type: research

A prospective analysis evaluating tissue biopsy location and its clinical relevance in chronic rhinosinusitis with nasal polyps
ConclusionAlthough ECP in NP was higher than in UT tissue, eosinophilia in UT tissue was a more clinically coherent biomarker of baseline radiographic severity, comorbid asthma and AERD, and prospective polyp recurrence risk than NP eosinophilia.
Source: International Forum of Allergy and Rhinology - August 1, 2017 Category: Allergy & Immunology Authors: Ava R. Weibman, Julia He Huang, Whitney W. Stevens, Lydia A. Suh, Caroline P.E. Price, Alcina K. Lidder, David B. Conley, Kevin C. Welch, Stephanie Shintani ‐Smith, Anju T. Peters, Leslie C. Grammer, Atsushi Kato, Robert C. Kern, Robert P. Schleimer, Br Tags: ORIGINAL ARTICLE Source Type: research

Diffuse Esophageal Spasm: Corkscrew Esophagus
An 84-year-old man with a 1-year history of progressive dysphagia, regurgitation of food, chest pain, and weight loss presented to our outpatient department. He had no previous cardiovascular or gastrointestinal problems, or history of an allergy. He did not experience ataxia, loss of consciousness, disorientation, or difficulty swallowing. His vital signs were normal. A plain radiograph showed no abnormality. Complete blood examination, including blood chemistry analysis, was unremarkable. Upper gastrointestinal endoscopy revealed circular folds in the distal esophagus (i.e., corkscrew esophagus, Figure 1A).
Source: The American Journal of Medicine - September 21, 2017 Category: General Medicine Authors: Hiroki Matsuura Tags: Clinical Communication to the Editor Source Type: research

Comparison of surgical outcomes between patients with unilateral and bilateral chronic rhinosinusitis
ConclusionPatients with unilateral CRSsNP experience improvement after ESS comparable to patients with bilateral disease on patient reported outcome measures.
Source: International Forum of Allergy and Rhinology - September 22, 2017 Category: Allergy & Immunology Authors: Daniel M. Beswick, Jess C. Mace, Naweed I. Chowdhury, Jeremiah A. Alt, Peter H. Hwang, Adam S. DeConde, Timothy L. Smith Tags: ORIGINAL ARTICLE Source Type: research

Traffic-Related Air Pollution and All-Cause Mortality during Tuberculosis Treatment in California
Conclusions: Residential proximity to road traffic volumes and traffic density were associated with increased all-cause mortality in patients undergoing treatment for active tuberculosis even after adjusting for multiple demographic, socioeconomic, and clinical factors, suggesting that TB patients are susceptible to the adverse health effects of traffic-related air pollution. https://doi.org/10.1289/EHP1699 Received: 31 January 2017 Revised: 18 August 2017 Accepted: 23 August 2017 Published: 29 September 2017 Address correspondence to R.J. Blount, Divisions of Pulmonary and Critical Care Medicine and Pediatric Pulmon...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

CD4 T cell –restricted IL-2 signaling defect in a patient with a novel IFNGR1 deficiency
A female child was referred to our institution at age 20  months after a protracted course of a febrile illness and cough associated with radiographic findings, demonstrating a large necrotic suprahilar lymph node impinging on the right main stem bronchus. Culture of the lymph node biopsy specimen, blood, and sputum identified Mycobacterium fortuitum an d Mycobacterium avium complex, whereas bronchoalveolar lavage specimen culture revealed the presence of Moraxella species. Other clinical findings included severe eczema for the first 6 months of life that was controlled by emollient use, development of chicken pox after...
Source: Journal of Allergy and Clinical Immunology - September 16, 2017 Category: Allergy & Immunology Authors: Aaruni Khanolkar, Dawn A. Kirschmann, Edward A. Caparelli, Jeffrey D. Wilks, Jillian M. Cerullo, Jenna R.E. Bergerson, Lawrence J. Jennings, Ramsay L. Fuleihan Tags: Letter to the Editor Source Type: research

Use of carbon dioxide as an intravascular contrast agent: A review of current literature.
Abstract Use of X-ray contrast allows us to differentiate between two or more adjacent structures on radiographic studies. The X-ray contrast agent can be the one with increase X-ray absorption, like iodine and a barium X-ray contrast agent or the one with decrease X-ray absorption like air and carbon dioxide contrast agent. Each contrast agent possesses different risks and benefits in various ways. Carbon dioxide as an intravascular contrast agent can be used as an alternative intravascular contrast agent and has superior results in some cases. In patients with renal dysfunction or iodinated contrast allergy, the...
Source: World Journal of Cardiology - September 26, 2017 Category: Cardiology Authors: Ali F, Mangi MA, Rehman H, Kaluski E Tags: World J Cardiol Source Type: research

Dupilumab improves all ACQ-5 individual items in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) and asthma: results from a phase 2a trial
Conclusion: In CRSwNP pts with asthma, DPL significantly improved all asthma-related items. Improvement correlated with reduced nasal polyp burden.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Hellings, P., Bachert, C., Mullol, J., Hamilos, D., Naclerio, R., Joish, V., Mannent, L., Amin, N., Abbe, A., Taniou, C., Pirozzi, G., Graham, N., Khan, A. Tags: Allergy and immunology Source Type: research

Clinical characteristics and outcome of patients with allergic bronchopulmonary aspergillosis
Conclusion: ABPA is commonly misdiagnosed as pulmonary TB in high burden TB country. Early diagnosis and appropriate treatment can prevent the structural damage to the lungs.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Khan, I., Aziz, K., Irfan, M., Iqbal, N. Tags: Allergy and immunology Source Type: research

What is the appropriate timing for endoscopic and radiographic surveillance following treatment for sinonasal malignancies?
Source: The Laryngoscope - December 8, 2017 Category: ENT & OMF Authors: Arjun K. Parasher, Edward C. Kuan, Maie A. St. John, Bobby A. Tajudeen, Nithin D. Adappa Tags: Allergy/Rhinology Source Type: research

What is DIOS?
Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are l...
Source: PediatricEducation.org - December 18, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Treatment of chronic rhinosinusitis with dornase alfa in patients with cystic fibrosis: a systematic review
ConclusionTopical intranasal dornase appears to improve sinonasal symptoms in CF patients to a greater degree than saline alone. The impact on other outcomes is less clear. Larger studies are needed to fully elucidate the true efficacy of dornase alfa in the treatment of CRS in CF patients.
Source: International Forum of Allergy and Rhinology - January 11, 2018 Category: Allergy & Immunology Authors: Gopi B. Shah, Linde Keyzer, Joy A. Russell, Ashleigh Halderman Tags: ORIGINAL ARTICLE Source Type: research