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Total 453 results found since Jan 2013.

Topical tacrolimus for the treatment of severe allergic keratoconjunctivitis in children
Conclusion: Topical TCL was effective and significantly improved the clinical signs of allergic keratoconjuctivitis in children. Thus, it is a potential new option for severe and challenging cases of ocular allergy.RESUMO Objetivos: O tratamento da ceratoconjuntivite al érgica baseado em colírios que contenham anti-histamínicos ou cromoglicato de sódio e seus derivados geralmente são insuficientes. A adição de corticosteróides geralmente é mandatória. No entanto, o risco de complicações como glaucoma e catarata limita o uso dos corticosteróides em curt os períodos de tratamento resultando em respostas inadequ...
Source: Arquivos Brasileiros de Oftalmologia - September 21, 2017 Category: Opthalmology Source Type: research

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Local bivalve allergens
ConclusionThis minireview will provide a  better understanding of each allergen derived from local bivalves which subsequently will help in the understanding of the specific immunoglobulin E(IgE)-mediated immune response.
Source: Allergo Journal International - March 16, 2018 Category: Allergy & Immunology Source Type: research

Excipient and Dose per Unit Area Affect Sensitivity When Patch Testing With Gold Sodium Thiosulfate.
CONCLUSIONS: Gold sodium thiosulfate HYD 0.075 mg/cm is the optimal dose for diagnosis of gold contact allergy with GST. Gold sodium thiosulfate 0.5% pet yielded false-negatives in some patients, suggesting inadequate dose per centimeter squared. Late reads are normal, expected, and necessary for diagnosis of gold contact allergy in this cohort. PMID: 30179971 [PubMed - as supplied by publisher]
Source: Dermatitis - August 31, 2018 Category: Dermatology Authors: Hamann D, Bruze M, Fowler JF, Hamann CR, Andersen KE, Hamann CP Tags: Dermatitis Source Type: research

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model
This study was also partly funded by a research contract from GSK. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the funders. Conflict of Interest Statement AG-S, FK, and PP are inventors in patent applications filed and owned b
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
Conclusions As the intestinal mucosa surface constitutes the major surface of the body which is in direct contact with the outer environment, intestinal immune homeostasis must be accurately regulated. The interplay between commensal microbiota, intestinal stromal cells, and the mucosal immune system components should guarantee the intestinal homeostasis to avoid a sustained inflammation that could induce tissue damage. However, several factors can lead to inflammation through homeostasis breakdown. Figure 1 summarizes the main points that have been reviewed here. We have described what it is known so far about the role o...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Core Gut Bacteria Analysis of Healthy Mice
Conclusion In conclusion, our results exhibited a relatively complete picture of core gut bacteria in healthy mice that they were mainly composed of carbohydrate- and amino acids-metabolizing bacteria and immunomodulatory bacteria, as well as their ecological relationships of symbiosis or functional redundancy. It was worth noting that the core bacteria resident in healthy gut was of fundamental importance for not only the healthy physiological characteristics, but also the chronic metabolic disease phenotypes. Our study focused on the gut microbiota of healthy host, and would be an important complement to the case–...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria
This study was conducted in the rural village of Kalifabougou, Mali where intense P. falciparum transmission occurs from June to December each year. Isolation of Tonsil B Cells Tonsils were mechanically disrupted in complete RPMI (RPMI 1640 with L-glutamine supplemented with 10% heat-inactivated FBS, 1 mM sodium pyruvate, 1% MEM nonessential amino acids, 50 μM 2-mercaptoethanol, 100 U/ml penicillin, 100 μg/ml streptomycin, and 25 mM HEPES, pH 7.2–7.5 [all from GIBCO, Invitrogen]) and passed through a 70-μm cell strainer to make a single cell suspension. B cells were then negatively selecte...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

Adverse reactions to food additives in children: A retrospective study and a prospective survey.
CONCLUSIONS: Allergies to food additives remain rare. Even if an IgE-mediated allergy was excluded with a negative OFC, families remained suspicious about ready-made products. Health professionals and parents should be reassured about the low risk of food dye intolerance or allergies. PMID: 32807620 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - August 14, 2020 Category: Pediatrics Authors: Lemoine A, Pauliat-Desbordes S, Challier P, Tounian P Tags: Arch Pediatr Source Type: research

Expanding Patch Testing Beyond the Baseline Series: Usefulness of Customized Antimicrobials, Vehicles, and Cosmetics Series.
CONCLUSIONS: Although the expansion of the North American Contact Dermatitis Group standard screening series has decreased the yield from the AVC series from 21.1% to 13.9%, it still remains a useful adjunct for patients suspected of having cosmetics or disinfectants allergy. PMID: 33074937 [PubMed - as supplied by publisher]
Source: Dermatitis - October 16, 2020 Category: Dermatology Authors: Morin CB, Sasseville D Tags: Dermatitis Source Type: research

Pharmacovigilance of cutaneous adverse drug reactions in associations with drugs and medical conditions: a retrospective study of hospitalized patients
CONCLUSIONS: Drug-induced CADR symptoms are commonly associated with other ARDs, predominantly rashes and pruritus, and are often accompanied by some medical conditions, especially liver and kidney damage. Detailed attention to a patient's primary diseases, allergy history, and drug safety profile could help prevent or reverse CADR in most patients.PMID:35948985 | DOI:10.1186/s40360-022-00603-4
Source: BMC Pharmacology and Toxicology - August 10, 2022 Category: Drugs & Pharmacology Authors: Lei Zheng Hao-Bin Jin Yu-Yao Guan Jing Yang Source Type: research