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Complete Remission of BCG-Refractory High-grade Bladder CIS with Pharmacologic Ascorbate and Mistletoe
CONCLUSIONS: This study is the first reported instance of combined treatments to achieve complete remission for high-grade NMIBC refractory to BCG and MIT-C, using intravesical, subcutaneous, and intravenous mistletoe and intravenous PA. It includes pharmacological information on possible mechanisms. In light of the global shortage of BCG, the high proportion of cases refractory to BCG and MIT-C, the unproven use of costly off-label pharmaceuticals, such as gemcitabine, and the relative cost-effectiveness of mistletoe and PA, clinicians should give serious consideration to employing these combined functional medicine treat...
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Devra Davis Dugald Seely Christopher Morash Jennifer Armstrong Maxwell Meng Phillip Lowe Mikhail Kogan Source Type: research

In silico Identification and Mechanism Exploration of Hepatotoxic Ingredients in Traditional Chinese Medicine
Conclusion: Overall, this study provides a high accurate approach to predict HILI and an in silico perspective into understanding the hepatotoxicity mechanism of TCM, which might facilitate the discovery and development of new drugs. Introduction Liver injury induced by drug, novel foods or phytotherapy, also known as hepatotoxicity, is still a major clinical and pharmaceutical concern (Amadi and Orisakwe, 2018; Hammann et al., 2018; Kyawzaw et al., 2018; Real et al., 2018). According to the data from United States National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), hepatotoxicity accounts for...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Health Behavior Change and Complementary Medicine Use: National Health Interview Survey 2012.
Conclusions: A sizeable proportion of respondents were motivated by their CAM use to undertake health behavior changes. CAM practices and practitioners could help improve patients' health behavior and have potentially significant implications for public health and preventive medicine initiatives; this warrants further research attention. PMID: 31554323 [PubMed - in process]
Source: Medicina (Kaunas) - September 23, 2019 Category: Universities & Medical Training Authors: Bishop FL, Lauche R, Cramer H, Pinto JW, Leung B, Hall H, Leach M, Chung VC, Sundberg T, Zhang Y, Steel A, Ward L, Sibbritt D, Adams J Tags: Medicina (Kaunas) Source Type: research

Novel targets of pentacyclic triterpenoids in Staphylococcus aureus: a systematic review
ConclusionsThe inhibitory mechanisms of S. aureus in novel targets and pathways should stimulate further researches to develop AM, BA and BE as therapeutic agents for infections caused by S. aureus. Continued efforts to identify and exploit synergistic combinations by the three compounds and peptidoglycan inhibitors, are also necessary as alternative treatment options for S. aureus infections.Graphical abstractPentacyclic triterpenoids are based on a 30-carbon skeleton comprising five six-membered rings (alpha-amyrin), and four six-membered rings and one five-membered ring (betulinic acid and betulinaldehyde). Transcriptom...
Source: Phytomedicine - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnopharmacology, Phytochemistry, and Pharmacology of the Genus Glehnia: A Systematic Review.
Authors: Yang M, Li X, Zhang L, Wang C, Ji M, Xu J, Zhang K, Liu J, Zhang C, Li M Abstract Glehnia littoralis Fr. Schmidt ex Miq, the sole species in the genus Glehnia (Apiaceae), has long been used in traditional Chinese medicine to treat fatigue, weakness, stomach-yin deficiency, lung heat, cough, dry throat, and thirst. Recently, G. littoralis has also been incorporated into a wide range of Chinese vegetarian cuisines. Based on the comprehensive information, advances in botany, known uses, phytochemistry, pharmacology, and toxicity of G. littoralis, we aim to highlight research gaps and challenges in studying G....
Source: Evidence-based Complementary and Alternative Medicine - January 11, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Persian herbal medicine in functional dyspepsia: a systematic review article.
CONCLUSION: Many people use herbal and traditional remedies for treatment of disorders such as gastrointestinal disordersو , especially in Asian countries. Several studies reported the efficacy of herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD. PMID: 32525777 [PubMed - as supplied by publisher]
Source: Current Drug Discovery Technologies - June 10, 2020 Category: Drugs & Pharmacology Authors: Azimi M, Zahedi MJ Tags: Curr Drug Discov Technol Source Type: research

The positive role of traditional Chinese medicine as an adjunctive therapy for cancer
Biosci Trends. 2021 Aug 20. doi: 10.5582/bst.2021.01318. Online ahead of print.ABSTRACTTraditional Chinese medicine (TCM), especially Chinese herbal medicines and acupuncture, has been traditionally used to treat patients with cancers in China and other East Asian countries. Numerous studies have indicated that TCM not only alleviates the symptoms (e.g., fatigue, chronic pain, anorexia/cachexia, and insomnia) of patients with cancer and improves their quality of life (QOL) but also diminishes adverse reactions and complications caused by chemotherapy, radiotherapy, or targeted-therapy. Therefore, Chinese herbal medicines a...
Source: BioScience Trends - August 23, 2021 Category: Biomedical Science Authors: Xiaoyi Zhang Hua Qiu Chensheng Li Pingping Cai Fanghua Qi Source Type: research

Effect of Compound Kushen Injection, a Natural Compound Mixture, and Its Identified Chemical Components on Migration and Invasion of Colon, Brain, and Breast Cancer Cell Lines
Conclusion The primary outcome of this study is the demonstration that cancer cell migration and invasion rates are significantly reduced by CKI, suggesting that therapeutic activity of CKI in human cancer patients may arise in part from downregulation of a panel of key molecular targets necessary for adhesion and motility in metastasis. The secondary outcome of this study is that multiple compounds in CKI, acting together, are responsible for this effect. Data Availability Data were submitted to NCBI Gene Expression Omnibus (GEO), with RNA_Seq. Accession Number GSE125743, available at https://www.ncbi.nlm.nih.g...
Source: Frontiers in Oncology - April 25, 2019 Category: Cancer & Oncology Source Type: research

The Effects of Add-on Therapy of Phyllanthus Emblica (Amla) on Laboratory Confirmed COVID-19 Cases: A Randomized, Double-blind, Controlled Trial
CONCLUSION: Organic herbal Amla tea cannot significantly affect the RT-PCR results and or degree of lung involvement. Nevertheless, it showed an ameliorative effect on the severity of clinical signs and CRP levels. Also, Amla tea may shorten the recovery times of symptoms and LOS in COVID-19 patients.PMID:35093510 | DOI:10.1016/j.ctim.2022.102808
Source: Complementary Therapies in Medicine - January 30, 2022 Category: Complementary Medicine Authors: Mehran Varnasseri Amir Siahpoush Khojasteh Hoseiny Nejad Fatemeh Amini Masoumeh Karamian Mohammad Jafar Yad Yad Bahman Cheraghian Azar Dokht Khosravi Source Type: research

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