In silico Identification and Mechanism Exploration of Hepatotoxic Ingredients in Traditional Chinese Medicine

Conclusion: Overall, this study provides a high accurate approach to predict HILI and an in silico perspective into understanding the hepatotoxicity mechanism of TCM, which might facilitate the discovery and development of new drugs. Introduction Liver injury induced by drug, novel foods or phytotherapy, also known as hepatotoxicity, is still a major clinical and pharmaceutical concern (Amadi and Orisakwe, 2018; Hammann et al., 2018; Kyawzaw et al., 2018; Real et al., 2018). According to the data from United States National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), hepatotoxicity accounts for 50% of all liver failure cases in the United States (Tujios and Fontana, 2011). Additionally, it is one of the leading causes of drug failure in trials and withdrawal from the market (Segall and Barber, 2014). Over the last decades, Traditional Chinese Medicine (TCM), regarded as safe and natural, has received growing attention (Vikas and Singh, 2012). Dating back to 2,500 years ago, TCM has played an irreplaceable role in Chinese health care system to fight against various diseases and keep health for Chinese people (Cheung, 2011). Moreover, TCM is a gorgeous cradle of new active compounds in the course of drug discovery. For example, artemisinin (Qinghaosu) (Tu, 2011) is an effective anti-malaria drug, which is extracted from Chinese herb Artemisia annua L. (Qinghao). Despite its long clinical success, the most annoying problem in the herbal TCM area is ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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