Novel targets of pentacyclic triterpenoids in Staphylococcus aureus: a systematic review

ConclusionsThe inhibitory mechanisms of S. aureus in novel targets and pathways should stimulate further researches to develop AM, BA and BE as therapeutic agents for infections caused by S. aureus. Continued efforts to identify and exploit synergistic combinations by the three compounds and peptidoglycan inhibitors, are also necessary as alternative treatment options for S. aureus infections.Graphical abstractPentacyclic triterpenoids are based on a 30-carbon skeleton comprising five six-membered rings (alpha-amyrin), and four six-membered rings and one five-membered ring (betulinic acid and betulinaldehyde). Transcriptomic analyses revealed these three compounds regulate multiple desirable targets in cell division, two-component system, and the biosynthesis of fatty acid, peptidoglycan and aminoacyl-tRNA..
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research