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A133: Initial Benchmarking of the Quality of Medical Care of Children and Adolescents with Lupus
Conclusion:Based on this initial benchmarking effort, the medical care of patients with cSLE at tertiary pediatric rheumatology centers is very good. Systematic planning and documentation of patient education on lifestyle modifications seems warranted and is expected to improve the self‐management skills of cSLE patients. Furthermore, increased focus on bone health, eye exams annually, and adequate vaccination of cSLE patients are areas to continue to monitor.
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: Ahmad I. Zaal, Simone Appenzeller, Julia G. Harris, Marco F. Silva, Jiha Lee, Maraisa Centeville, HaiMei Liu, Joshua D. Pendl, Jennifer L. Huggins, Anne Johnson, Clovis A. Silva, Brunner Hermine Tags: Poster Presentations Source Type: research

What Areas of the Physical Examination are Important in the Pre-participation Physical Examination?
Discussion Participation in organized or non-organized, recreational to elite sports activities can provide excellent recreational and leisure time activities and improve physical and mental health for participants. The Aspen Institute in 2018 reported that more kids are being physically active, more are trying different sports, and multisports play is increasing rather than strict specialization. Unfortunately they note that there is an economic inequality with children from lower-socioeconomic circumstances playing less organized sports. About 70% of children and youth participate in an individual or team sport, but unfo...
Source: PediatricEducation.org - December 7, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Vitamins: stop taking the pills
This article was corrected on 7 June 2013. During editing, a line in the fifth from last paragraph, beginning 'Another example is St John's wort…' was accidentally transposed, leading to the suggestion that serotonin was a medicine rather than a brain chemical.Alternative medicineHealth & wellbeingHealthCancerCancerMedical researchPharmaceuticals industryDepressionguardian.co.uk © 2013 Guardian News and Media Limited or its affiliated companies. All rights reserved. | Use of this content is subject to our Terms & Conditions | More Feeds    
Source: Guardian Unlimited Science - June 7, 2013 Category: Science Tags: The Guardian Depression Pharmaceuticals industry Health Medical research & wellbeing Society Extracts Features Cancer Life and style Alternative medicine Science Source Type: news

Health claims about vitamin D examined
Rarely a month goes by without the papers reporting at least one health news story related to vitamin D. In recent weeks the media has reported that vitamin D can help relieve the symptoms of asthma and lower blood pressure. There have been long-standing claims that vitamin D brings a wide range of benefits, from preventing cancer risk to improving mental health, or even reducing your risk of getting multiple sclerosis. But is there good evidence to back up the claims? And do you need to change your diet or take vitamin D supplements to reduce your risk of disease?   What is vitamin D? Vitamin D is a group of related m...
Source: NHS News Feed - June 18, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Medical practice QA articles Special reports Source Type: news

Imperatives for DUCHENNE MD: a Simplified Guide to Comprehensive Care for Duchenne Muscular Dystrophy
Conclusion “Imperatives for Duchenne MD” is a very focused and brief snapshot of the essential components of comprehensive DMD care as described in the CDC care considerations. This information is meant for health care providers, but can also be used by patients and parent advocating for comprehensive care for themselves or their children. The document has so far been translated into 18 languages by patient organizations and professional volunteers around the world through the TREAT-NMD Alliance. More detailed information for each area of care and the care required for each stage of Duchenne, as well as the complete ...
Source: PLOS Currents Muscular Dystrophy - August 7, 2015 Category: Neurology Authors: Kathi Kinnett Source Type: research

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
María Maximina B. Moreno-Altamirano1*, Simon E. Kolstoe2 and Francisco Javier Sánchez-García1* 1Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 2School of Health Sciences, University of Portsmouth, Portsmouth, United Kingdom Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathw...
Source: Frontiers in cellular and infection microbiology - April 17, 2019 Category: Microbiology Source Type: research

Modeling Streptococcus pyogenes Pharyngeal Colonization in the Mouse
In conclusion, the mouse pharyngeal colonization model is an affordable and accessible experimental system that allows a broader group of research groups to test the importance of their findings in an in vivo model. There is a great deal of overlap between the bacterial and immune factors found to be important in human and murine pharyngeal colonization. Although MHC-II humanized mice could prove useful in answering certain questions, the use of inbred mouse lines appears to be sufficient for evaluation of most questions, both related to bacterial factors and the host immune response. However, when promising treatments or ...
Source: Frontiers in cellular and infection microbiology - May 1, 2019 Category: Microbiology Source Type: research

What's the Connection between Fever and Atraumatic Leg Pain?
​BY ADRIANA PORTO, MD; KELLY LEVASSEUR, DO; & SHANNA JONES, MDA 7-year-old girl presented to the emergency department with intermittent low-grade fever over the previous six days. She also had a sore throat, cough, and nasal congestion. Her mother reported a fever of 105°F with vomiting, cough, and congestion on the day of her presentation. She also noted that the patient complained of right leg pain and refused to walk or bear weight on her right leg, which was new the day of presentation. The patient pointed to the back of her right calf when asked where the pain was located. Her mother said the patient did not ha...
Source: The Case Files - June 18, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Janssen Announces Submission to U.S. FDA for New DARZALEX ® (Daratumumab)-Based Combination Regimen for Patients with Relapsed/Refractory Multiple Myeloma
RARITAN, NJ, February 10, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the submission of a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) seeking approval of DARZALEX® (daratumumab) in combination with Kyprolis® (carfilzomib) and dexamethasone (DKd) for relapsed/refractory multiple myeloma. The sBLA is supported by results from the Phase 3 CANDOR study, which compared treatment with DKd to carfilzomib and dexamethasone (Kd) in patients with multiple myeloma who relapsed after one to three prior lines of therapy. “While we contin...
Source: Johnson and Johnson - February 10, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Does vitamin D cut lung infection risk in older adults?
Conclusion This randomised controlled trial assessed high dose supplementation with vitamin D for a period of 12 months as a way of preventing acute respiratory infections in older adults in long term care. This study was well designed and reduced risk of bias where possible. However, there are some important limitations which affect the reliability of the findings: The study has a small sample size and the authors state they did not manage to reach their target recruitment level; this means the study did not have the statistical power required for certainty in the findings. There were some differences in the character...
Source: NHS News Feed - November 18, 2016 Category: Consumer Health News Tags: Heart/lungs Older people Source Type: news

Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction
We describe the unexpected binding of S-layer to cells devoid of DC-SIGN but also confirm that the presence of DC-SIGN was essential for S-layer’s antiviral activity. S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al., 2017). Together our results suggest that inhibition of viral entry by S-layer occurs via a novel S-layer/DC-SIGN interaction. Materials and Methods Isolation of S-Layer Proteins S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by usi...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Downregulation of calcium-regulated heat stable protein 1 expression by low-temperature stimulation causes reduction of interferon- β expression and sensitivity to influenza viral infection
Virus Res. 2021 Dec 17:198659. doi: 10.1016/j.virusres.2021.198659. Online ahead of print.ABSTRACTInfluenza is prevalent in temperate countries during winter when the environment is dry and cold; however, in tropical and subtropical countries, it is prevalent during the hot, humid rainy season. Thus, temperature and humidity conditions affect influenza outbreaks in different climates. Although the reason for this may be related to host conditions and the conditions under which the virus can survive, it is difficult to analyze changes in host viral responses owing to environmental changes at the cellular level. In the curre...
Source: Virus Research - December 20, 2021 Category: Virology Authors: Keisuke Nishioka Tomo Daidoji Takaaki Nakaya Source Type: research