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Encountering Chronic Sore Throat: How Challenging is it for the Otolaryngologists?
Conclusion The study provided with a detailed account of the heterogeneous etiology of chronic sore throat, and an overall structured idea on how to approach to its work-up and diagnosis. Proper history taking and appropriate structured investigations are the keys. Chronic tonsillopharyngitis, gastroesophageal reflux disorder, submandibular sialadenitis, and laryngopharyngeal reflux disorder were the chief causes of chronic sore throat.
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - September 6, 2017 Category: ENT & OMF Source Type: research

Teaching frontal sinus anatomy using the frontal sinus masterclass 3 ‐ D conceptualization model
ConclusionObjectively, participants of the FSMC expanded on their ability to recognize cells of the frontal recess on CT scans. Before the class, residents could answer less than half of the answers correctly, and by the end of the class they were answering over two‐thirds of these complex questions correctly. Subjectively, participants reported benefit from the course and felt they would be better surgeons. Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - November 24, 2017 Category: ENT & OMF Authors: Philip G. Chen, K. Christopher McMains, Marc A. Tewfik, James K. Aden, Seth Brown, Erik K. Weitzel Tags: Allergy/Rhinology Source Type: research

Medical laboratory technician professional pathologies: a 2006-2016 literature review.
In conclusion, TL can present many occupational pathologies. Few articles studied the prevalence of MSD and BO. PMID: 29192599 [PubMed - in process]
Source: Annales de Biologie Clinique - December 1, 2017 Category: Biochemistry Authors: Pougnet R, Loddé B, Uguen M, Sawicki B, Pougnet L Tags: Ann Biol Clin (Paris) Source Type: research

Antihypertensive-related adverse drug reactions among older hospitalized adults
Conclusions ADRS associated with antihypertensive medicines were relatively common among older adults admitted to hospital. Increased awareness of those older persons who are most at risk of experiencing an antihypertensive-related ADR in the clinical setting may lead to early detection and minimization of ADR associated harms.
Source: International Journal of Clinical Pharmacy - February 1, 2018 Category: Drugs & Pharmacology Source Type: research

Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients
CONCLUSIONS: Adverse drug reactions are frequent and potentially serious and should be better monitored in patients with chronic renal failure or prolonged hospitalization and especially in those on ‘ polypharmacy ’ regimens. The rational use of medications plays an important role in preventing adverse drug reactions.
Source: Clinics - February 8, 2018 Category: General Medicine Source Type: research

Feasibility and Safety of Cockroach Nasal Allergen Challenge (NAC) in Cockroach Sensitized Children and Adults with Asthma: A Multi-Site, Open-Label Pilot Study (Inner City Asthma Consortium)
NAC may offer an objective means to assess cockroach allergen-specific airway reactivity and response to therapy with allergen immunotherapy (AIT), but feasibility and safety information in children with asthma is limited.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Amanda K. Rudman Spergel, Michelle L. Sever, Jacqueline Johnson, Michelle A. Gill, Carolyn Kercsmar, Dan A. Searing, Stephanie Lovinsky-Desir, Stephen J. Teach, James E. Gern, William W. Busse, Alkis Togias, Robert A. Wood, Andrew H. Liu Source Type: research

Caregiver Perceptions of Epinephrine Autoinjector Training
Epinephrine autoinjectors (EAI) are life-saving devices, however, many caregivers have reported unease with their use. Teaching for EAI use may vary by clinician and treatment setting. The goal of this study is to assess the caregiver perspective regarding epinephrine autoinjectors at a large pediatric referral center.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Gretchen A. Harmon, Magee L. DeFelice Source Type: research

Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helminths attending Kampala International University Teaching Hospital, in Uganda
Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with l...
Source: Allergy, Asthma and Clinical Immunology - March 19, 2018 Category: Allergy & Immunology Authors: Richard Bwanika, Charles D. Kato, Johnson Welishe and Daniel C. Mwandah Tags: Research Source Type: research

Epithelial cell gene networks upregulated in obese asthmatic children
Obesity is a major pediatric health concern affecting almost 20% of American children and adolescents. Obesity is a risk factor for the development of asthma and is associated with increased asthma severity. Children with obesity and asthma have reduced responsiveness to inhaled corticosteroids, increased use of systemic corticosteroids during exacerbations, and a reduced FEV1/FVC ratio. The mechanisms underlying the influence of obesity on asthma pathogenesis remain poorly understood.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Huang, C. Swanson, D. Babineau, E. Whalen, M. Gill, B. Shao, A. Liu, B. Jepson, R. Gruchalla, G. O'Connor, J. Pongracic, C. Kercsmar, G. Khurana Hershey, E. Zoratti, C. Johnson, S. Teach, M. Kattan, L. Bacharier, A. Beigelman, S. Sigelman, P. Gergen, L Tags: A203 Source Type: research

Design and development of a simulation game for parents of preschool children with asthma: an evidence-based approach
Introduction: Asthma in preschool children is characterized by severe and frequent exacerbations, leading to high rates of emergency department visits and hospital admissions. Teaching parents the early management of asthma exacerbations at home might reduce healthcare use. Serious games, because they allow active and experiential learning, represent an interesting way to train parents on the management of asthma exacerbations.Objective: To design and develop a serious game to teach parents of preschool children the management of asthma exacerbations starting at home, following an evidence-based approach.Results: We conduc...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Drummond, D., Tesniere, A., Hadchouel, A. Tags: Paediatric asthma and allergy Source Type: research

A computerized decision support tool to implement asthma guidelines for children and adolescents
The acceptance and performance of a guideline-based, computerized decision support tool to assess and score asthma control and then provide appropriate treatment step for inner-city children and adolescents with poorly controlled asthma was excellent.
Source: Journal of Allergy and Clinical Immunology - December 5, 2018 Category: Allergy & Immunology Authors: Carolyn M. Kercsmar, Christine A. Sorkness, Agustin Calatroni, Peter J. Gergen, Gordon R. Bloomberg, Rebecca S. Gruchalla, Meyer Kattan, Andrew H. Liu, George T. O ’Connor, Jacqueline A. Pongracic, Stanley J. Szefler, Stephen J. Teach, Jeremy J. Wildfir Source Type: research

Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial
CONCLUSION Earlier reports of increased pain sensitivity 1 year after the use of remifentanil could not be confirmed in this randomised study using Quantitative Sensory Testing. This indicates that remifentanil plays a minor role in the development of chronic thoracic pain. Still, the relatively high incidence of chronic thoracic pain and its accompanying impact on quality of life remain challenging problems. TRIAL REGISTRATION The study was registered at EudraCT (ref: 2013-000201-23) and ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT02031016).
Source: European Journal of Anaesthesiology - December 7, 2018 Category: Anesthesiology Tags: Postoperative pain Source Type: research

Type-1 Interferon and Th2-Type Gene Expression Responses and Childhood Asthma
Several studies have demonstrated that type-1 interferons (T1-IFN)s suppress Th2-type (T2) inflammation in vitro. Both pathways play important roles in asthma pathogenesis; however, their relationship in vivo is unknown. We investigated upper airway gene expression in children with asthma during disease stability, upper respiratory infections (URI)s, and asthma exacerbations to define the relationship between these pathways.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Jamie A. Rosenthal, Malisa T. Smith, Michelle A. Gill, Andrew H. Liu, Rebecca S. Gruchalla, George T. O'Connor, Jacqueline A. Pongracic, Carolyn Kercsmar, Gurjit K. Khurana Hershey, Edward M. Zoratti, Stephen J. Teach, Meyer Kattan, Leonard B. Bacharier, Source Type: research

Outcomes of Simulated Use of Epinephrine Injection USP Auto-injectors
Epinephrine administration is indicated in the emergency treatment of life threatening anaphylaxis. We evaluated the effectiveness of our office ’s teaching of self administration of epinephrine for patients at risk of anaphylaxis. The identification of common errors could then lead to adjustments in teaching that would improve patient’s long-term technique abilities.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Lindsey R. Peterson, Conor R. Cullinane, Matthew J. Kane, Mark E. Bubak Source Type: research

Inner-City Asthma in Childhood
The inner-city is a well-established and well-studied location that includes children at high risk for high asthma prevalence and morbidity. A number of intrinsic and extrinsic risk factors contribute to asthma in inner-city populations. This review seeks to explore these risk factors and evaluate how they contribute to increased asthma morbidity. Previous literature has identified risk factors such as race and ethnicity, prematurity, obesity, and exposure to aeroallergens and pollutants. Environmental and medical interventions aimed at individual risk factors and specific asthma phenotypes have contributed to improved out...
Source: Immunology and Allergy Clinics of North America - April 4, 2019 Category: Allergy & Immunology Authors: Amaziah T. Coleman, Stephen J. Teach, William J. Sheehan Source Type: research