Epithelial cell gene networks upregulated in obese asthmatic children

Obesity is a major pediatric health concern affecting almost 20% of American children and adolescents. Obesity is a risk factor for the development of asthma and is associated with increased asthma severity. Children with obesity and asthma have reduced responsiveness to inhaled corticosteroids, increased use of systemic corticosteroids during exacerbations, and a reduced FEV1/FVC ratio. The mechanisms underlying the influence of obesity on asthma pathogenesis remain poorly understood.

Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Huang, C. Swanson, D. Babineau, E. Whalen, M. Gill, B. Shao, A. Liu, B. Jepson, R. Gruchalla, G. O'Connor, J. Pongracic, C. Kercsmar, G. Khurana Hershey, E. Zoratti, C. Johnson, S. Teach, M. Kattan, L. Bacharier, A. Beigelman, S. Sigelman, P. Gergen, L Tags: A203 Source Type: research