Filtered By:
Education: Students

This page shows you your search results in order of relevance. This is page number 3.

Order by Relevance | Date

Total 90 results found since Jan 2013.

Regulatory Effect of 1,25(OH)2D3 on TGF- β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats.
Conclusion: TGF-β1 can decrease the expression of miR-130b in kidney tissues of DN rats. Moreover, miR-130b may be involved in the protective effect of 1,25(OH)2D3 on renal fibrosis via TGF-β1. PMID: 31781203 [PubMed]
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

MicroRNA expression changes following BCL11A inhibition in CD34+-derived red blood cells
CONCLUSIONS: The expression levels of miR-15a, miR-16, miR-23a, miR-27a, and miR-486 changed before and after γ-to-β gene switching. Therefore, this may be an effective intervention for controlling the switching and synthesis of fetal hemoglobin.PMID:33707350 | DOI:10.5045/br.2021.2020087
Source: Blood Research - March 12, 2021 Category: Hematology Authors: Narges Obidi Fatemeh Saberi Asad Taghavi Reza Ranjbaran Gholamreza Khamisi Pour Gholamhossein Tamaddon Source Type: research

Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq
ConclusionsThe 3 differentially expressed circRNAs may play an important role in the process of AST promoting cholesterol efflux and may be used as biomarkers to prevent AS.
Source: Genes and Nutrition - August 28, 2021 Category: Nutrition Source Type: research

Myostatin increases human trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 Signaling
In this study, we tested the hypothesis that myostatin increases trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 signaling. Primary and immortalized (HTR8/SVneo) trophoblast cells were used as study models. Matrigel-coated transwell invasion assays were used to study the effects of recombinant human myostatin on trophoblast cell invasion. RT-qPCR and Western blot were used to measure myostatin effects on N-cadherin mRNA and protein levels, respectively. Small inhibitor molecules as well as siRNA-mediated knockdown were used to block myostatin receptor and downstream signaling, respectively. Data were...
Source: Biology of Reproduction - January 12, 2022 Category: Reproduction Medicine Authors: Faten AbdelHafez Ahmed Christian Klausen Hua Zhu Peter C K Leung Source Type: research

MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
Conclusion: Our study’s results are consistent with miR-497 being a candidate tumor suppressor in neuroblastoma, through the direct targeting of WEE1. These findings re-enforce the proposal of WEE1 as a therapeutic target in neuroblastoma.
Source: Molecular Cancer - March 26, 2013 Category: Cancer & Oncology Authors: Laura CreeveyJacqueline RyanHarry HarveyIsabella BrayMaria MeehanAdnan KhanRaymond Stallings Source Type: research

Therapeutic Targeting of Integrin {alpha}v{beta}6 in Breast Cancer
Conclusions Targeting αvβ6 with 264RAD alone or in combination with trastuzumab may provide a novel therapy for treating high-risk and trastuzumab-resistant breast cancer patients.
Source: JNCI - June 28, 2014 Category: Cancer & Oncology Authors: Moore, K. M., Thomas, G. J., Duffy, S. W., Warwick, J., Gabe, R., Chou, P., Ellis, I. O., Green, A. R., Haider, S., Brouilette, K., Saha, A., Vallath, S., Bowen, R., Chelala, C., Eccles, D., Tapper, W. J., Thompson, A. M., Quinlan, P., Jordan, L., Gillett Tags: Article Source Type: research

Phosphorylation of AKT induced by phosphorylated Hsp27 confers the apoptosis-resistance in t-AUCB-treated glioblastoma cells in vitro
Abstract The aim of this study is to determine whether phosphorylation of AKT could be effected by t-AUCB-induced p-Hsp27 and whether p-AKT inhibition sensitizes glioblastoma cells to t-AUCB, and to evaluate the effects of simultaneous inhibition of p-Hsp27 and p-AKT on t-AUCB treated glioblastoma cells. Cell growth was detected using CCK-8 assay; Caspase-3 activity assay kits and flow cytometry were used in apoptosis analysis; Western blot analysis was used to detect p-Hsp27 and p-AKT levels; RNA interference using the siRNA oligos of Hsp27 was performed to knockdown gene expression of Hsp27. All data were analyz...
Source: Journal of Neuro-Oncology - September 9, 2014 Category: Cancer & Oncology Source Type: research

Gli-1 is crucial for hypoxia-induced epithelial-mesenchymal transition and invasion of breast cancer
The objective of this study was to evaluate the role of Gli-1, an effector of the Hedgehog pathway, in the hypoxia-induced EMT and invasion of breast cancer cells. Human breast cancer MDA-MB-231 cells were transfected with HIF-1α or Gli-1-specific small interfering RNA (siRNA) and cultured under a normoxic or hypoxic condition. The relative levels of HIF-1α, Gli-1, E-cadherin, and vimentin in the cells were characterized by quantitative RT-PCR and Western blot assays, and the invasion of MDA-MB-231 cells was determined. Data was analyzed by Student T test, one-way ANOVA, and post hoc LSD test or Mann-Whitney U when appli...
Source: Tumor Biology - December 14, 2014 Category: Cancer & Oncology Source Type: research

Carvedilol suppresses migration and invasion of malignant breast cells by inactivating Src involving cAMP/PKA and PKCδ signaling pathway
Conclusions: CAR was an anti-metastatic agent, which targets Src involving cAMP/PKA or PKCδ pathway in malignant breast cells.
Source: Journal of Cancer Research and Therapeutics - January 9, 2015 Category: Cancer & Oncology Authors: Gao DezongMa ZhongbingFu QinyeYu Zhigang Source Type: research

Investigation of the HIV‐1 Matrix interactome during virus replication
Conclusions and clinical relevance: The Strep‐tag allowed for the capture of viral protein complexes in the context of virus replication. Several previously described factors were identified and at least two candidate proteins were found to play a role in HIV‐1 infection. These data further increase our understanding of HIV‐host cell interactions.This article is protected by copyright. All rights reserved
Source: Proteomics. Clinical Applications - September 11, 2015 Category: Biochemistry Authors: Yan Li, Kristin M. Frederick, Nicole A. Haverland, Pawel Ciborowski, Michael Belshan Tags: Research Article Source Type: research

Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells
Background: Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis. Posttranslational regulation of HIF-1α is dependent on Prolyl hydroxylase (PHD 1–3) and Factor Inhibiting HIF (FIH) hydroxylase enzymes, which require ascorbic acid as a co-factor for optimal function. Depleted intra-tumoral ascorbic acid may thus play a role in the loss of HIF-1α regulation in melanoma. These studies assess the ability of ascorbic acid to reduce HIF-1α protein and transcriptional activity in metastatic melanoma and reduce its invasive potential. Methods: HIF-1α protein was evaluated by wester...
Source: BMC Cancer - November 7, 2015 Category: Cancer & Oncology Authors: Sarah MilesAdam FischerSandeep JoshiRichard Niles Source Type: research

Abstract B37: The histone deacetylase inhibitor panobinostat sensitizes cyclin E-amplified ovarian cancer cells to poly ADP ribose polymerase inhibitors via E2F1 downregulation.
Conclusions: The development of a new PARPi combination therapy with panobinostat has immediate prospects for rapid translation to the clinic and great potential for improving clinical outcomes for non-BRCAness, chemoresistant ovarian cancer.Citation Format: Andrew J. Wilson, Jeanette Saskowski, Dineo Khabele. The histone deacetylase inhibitor panobinostat sensitizes cyclin E-amplified ovarian cancer cells to poly ADP ribose polymerase inhibitors via E2F1 downregulation.. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR;...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Wilson, A. J., Saskowski, J., Khabele, D. Tags: Epigenetic Cancer Therapies Source Type: research

GPER expressed on microglia mediates the anti‐inflammatory effect of estradiol in ischemic stroke
ConclusionsOur studies have suggested that GPER expressed on microglia mediated the anti‐inflammatory effect of estradiol after ischemic stroke. Our studies could potentially help to develop more specific drugs to manage inflammation postischemic stroke. GPER was highly expressed in activated microglia after ischemia and estradiol. The specific GPER agonist G1 could inhibit the secretion of proinflammatory cytokines including IL‐1β and TNF‐α, which the anti‐inflammatory effect of G1 and E2 were both abolished by the specific GPER antagonist G15.
Source: Brain and Behavior - March 21, 2016 Category: Neurology Authors: Tian‐Zhi Zhao, Qian Ding, Jun Hu, Shi‐Ming He, Fei Shi, Lian‐Ting Ma Tags: Original Research Source Type: research