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Drug: Dexamethasone

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Total 197 results found since Jan 2013.

Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway
Conclusions: This is the first study to illustrate that EsA acts as a novel Nrf-2 activator, which modulates the oxidative stress pathway to improve lung injury and ameliorate the development of airway inflammation.Int Arch Allergy Immunol 2015;167:280-290
Source: International Archives of Allergy and Immunology - October 24, 2015 Category: Allergy & Immunology Source Type: research

MUC4 overexpression correlates corticoid resistance in chronic rhinosinusitis with nasal polyps
Conclusion: MUC4 participates in the corticoid response that mediates GRα nuclear translocation. The high expression of MUC4 in patients with CRSwNP may participate in corticoid resistance.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Contreras, S., Serrano, A., Diaz, L., Ballester, B., Banuls, P., Milara, J., Morell, A. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Mucin 1 downregulation associates with corticoid resistance in chronic obstructive pulmonary disease and chronic rhinosinusitis with nasal polyps
Conclusion: Corticoid response that mediates GRα nuclear translocation requires MUC1-CT. The low expression of MUC1 in patients with CRSwNP or COPD may participate in corticoid resistance.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Morell, A., Milara, J., Diaz, L., Ballester, B., Peiro, T., Gonzalez, S., Banuls, P., Cortijo, J. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

MUC1-CT mediates corticosteroid responses in COPD
Conclusions: MUC1-CT mediates the anti-inflammatory properties of corticosteroids and the lack of its expression in COPD increases resistance to corticosteroids.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Diaz, L., Milara, J., Morcillo, E., Serrano, A., Guijarro, R., Sanz, C., Cortijo, J. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Glucocorticoid-induced leucine zipper may play an important role in icariin by suppressing osteogenesis inhibition induced by glucocorticoids in osteoblasts
Conclusions These results indicate that the GILZ-mediated osteogenic signal pathway is involved in the osteogenic effect induced by icariin.
Source: Biomedicine and Pharmacotherapy - March 29, 2017 Category: Drugs & Pharmacology Source Type: research

Glucocorticoid-induced leucine zipper may play an important role in icariin by suppressing osteogenesis inhibition induced by glucocorticoids in osteoblasts.
CONCLUSIONS: These results indicate that the GILZ-mediated osteogenic signal pathway is involved in the osteogenic effect induced by icariin. PMID: 28363169 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2017 Category: Drugs & Pharmacology Authors: Lin Z, Jiang ZL, Chen LH, Sun Y, Chen SZ, Zhou P, Xia AX, Jin H, Zhu YW, Chen DY Tags: Biomed Pharmacother Source Type: research

Parathyroid hormone 1 ‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway.
Parathyroid hormone 1‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway. Mol Med Rep. 2018 Jun 27;: Authors: Wang XY, Jiao LY, He JL, Fu ZA, Guo RJ Abstract Osteoporosis is closely associated with intervertebral disc degeneration. While parathyroid hormone (PTH) 1‑34, which is an established drug used to treatosteoporosis, is thought to inhibit the disc degeneration associated with osteoporosis, the precise mechanism involved remains unclear. In the present study, primary Sprague‑Dawley rat nucleus pulposus cells (NPCs) were cultured, phenotyped...
Source: Molecular Medicine Reports - July 1, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Glucocorticoid induces osteonecrosis of the femoral head in rats through GSK3 β-mediated osteoblast apoptosis.
CONCLUSION: Our findings suggest that GC induces ONFH in rats through GSK3β-mediated osteoblast apoptosis, with involvement of mitochondrial apoptotic pathway. PMID: 30827503 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - February 27, 2019 Category: Biochemistry Authors: Nie Z, Chen S, Peng H Tags: Biochem Biophys Res Commun Source Type: research

Z-Guggulsterone attenuates glucocorticoid-induced osteoporosis through activation of Nrf2/HO-1 signaling
Publication date: Available online 21 March 2019Source: Life SciencesAuthor(s): Yier Xu, Jian Guan, Jianyu Xu, Shuilin Chen, Guicai SunAbstractAimsThe present study aims to investigate the protective effect and underlying mechanism of Z-Guggulsterone (Z-GS), an active component from myrrh, on glucocorticoid-induced osteoporosis (GIO).Main methodsGIO rats were used to simulate osteoporosis in vivo while MC3T3-E1 cells were induced to osteoblast differentiation and treated with dexamethasone to simulate osteoporosis in vitro. The rats and cells were treated with Z-GS according to the protocol. The bone mineral density, biome...
Source: Life Sciences - March 21, 2019 Category: Biology Source Type: research

Accumulation of hyaluronic acid in stromal cells modulates osteoclast formation by regulation of receptor activator of nuclear factor kappa-B ligand expression.
In this study, we investigated the effect and underlying mechanisms of HA accumulation on the expression of receptor activator of nuclear factor kappa-B ligand (RANKL) induced by 1α,25(OH)2D3 and dexamethasone in stromal cells, which support osteoclastogenesis. Degradation of HA by hyaluronidase (HA'ase) treatment enhanced the expression of RANKL in ST2 cells stimulated with 1α,25(OH)2D3 and dexamethasone. Down-regulation of hyaluronan synthase 2 (HAS2) expression by siRNA also stimulated RANKL expression induced by 1α,25(OH)2D3 and dexamethasone. Results from a cell co-culture system with bone marrow cell showed that 1...
Source: Biochemical and Biophysical Research communications - March 22, 2019 Category: Biochemistry Authors: Nakao Y, Hikiji H, Okinaga T, Takeuchi J, Habu M, Yoshiga D, Yoshioka I, Nishihara T, Ariyoshi W Tags: Biochem Biophys Res Commun Source Type: research

Silencing FOXO1 attenuates dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells.
Abstract Dexamethasone (DEX), a widely used glucocorticoid with strong anti-inflammatory and immunosuppressive activities, has been reported to induce apoptosis in osteoblasts, but the underlying mechanisms are still not comprehensively investigated. FOXO1 plays an important role in the regulation of cell proliferation and apoptosis. Our study aims to explore the role of FOXO1 in DEX-induced apoptosis of osteoblastic MC3T3-E1 cells through bioinformatics and experiments. We first employed bioinformatics to identify DEX-related genes and revealed their functions by GO enrichment analysis including FOXO1 associated ...
Source: Biochemical and Biophysical Research communications - April 18, 2019 Category: Biochemistry Authors: Xing L, Zhang X, Feng H, Liu S, Li D, Hasegawa T, Guo J, Li M Tags: Biochem Biophys Res Commun Source Type: research

Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1 β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor
Management of pain in the treatment of rheumatoid arthritis (RA) is a priority that is not fully addressed by the conventional therapies. In the present study, we evaluated the efficacy of cannabinoid receptor 2 (CB2) agonist JWH-015 using RA synovial fibroblasts (RASFs) obtained from patients diagnosed with RA and in a rat adjuvant-induced arthritis (AIA) model of RA. Pretreatment of human RASFs with JWH-015 (10-20 µM) markedly inhibited the ability of pro-inflammatory cytokine interleukin-1β (IL-1β) to induce production of IL-6 and IL-8 and cellular expression of inflammatory cyclooxygenase-2 (COX-2). JWH-015 was effe...
Source: Frontiers in Immunology - May 7, 2019 Category: Allergy & Immunology Source Type: research

Inhibition of NOX2-NLRP1 signaling pathway protects against chronic glucocorticoids exposure-induced hippocampal neuronal damage.
In this study, the lentivirus with NLRP1-siRNA was injected into the hippocampus of male mice which were then treated with dexamethasone (DEX, 5 mg/kg) for 28 d. The data indicated that NLRP1-siRNA treatment down-regulated the NLRP1 expression and significantly improved the exploratory behavior and spatial memory deficits in open field tests and Morris water maze which were deteriorated by chronic DEX treatment in mice. Additionally, inhibition of NLRP1 expression significantly alleviated neuronal degeneration and increased MAP2 expression in the hippocampus in mice. Meanwhile, the results showed that DEX exposure incr...
Source: International Immunopharmacology - June 26, 2019 Category: Allergy & Immunology Authors: Sun L, Chen Y, Shen X, Xu T, Yin Y, Zhang H, Ding S, Zhao Y, Zhang Y, Guan Y, Li W Tags: Int Immunopharmacol Source Type: research

Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma
The study is to investigate the effect of cryptotanshinone (CTS) on airway remodeling and the possible mechanism. Male BALB/c mice were pretreated with CTS or dexamethasone 30 min before nebulized inhalation of ovalbumin (OVA). CTS significantly inhibited OVA-induced increases of eosinophils and neutrophils infiltration of bronchoalveolar lavage fluids (BALFs), reduced airway resistance in asthmatic mice, decreased the accumulation of inflammatory cells, the hyperplasia of goblet cells and the deposition of collagen in asthmatic mice lung tissue, as well as markedly attenuated the leakage of inflammatory cells and the leve...
Source: Frontiers in Pharmacology - November 10, 2019 Category: Drugs & Pharmacology Source Type: research

Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4 Cell Biology
Glucocorticoids are potent endogenous anti-inflammatory molecules, and their cognate receptor, glucocorticoid receptor (GR), is expressed in nearly all immune cells. Macrophages are heterogeneous immune cells having a central role in both tissue homeostasis and inflammation and also play a role in the pathogenesis of some inflammatory diseases. Paradoxically, glucocorticoids have only a limited efficacy in controlling the resolution of these macrophage-related diseases. Here, we report that the transcriptomes of monocyte-like THP-1 cells and macrophage-like THP-1 cells (THP1-MΦ) have largely conserved gene expression patt...
Source: Journal of Biological Chemistry - March 5, 2020 Category: Chemistry Authors: David Diaz-Jimenez, Maria Grazia Petrillo, Jonathan T. Busada, Marcela A. Hermoso, John A. Cidlowski Tags: Gene Regulation Source Type: research